Deficiencies in the Fanconi anemia or homologous recombination pathway enhance the antitumor effects of the hypoxia-activated prodrug CP-506 [0.03%]
范可尼贫血或同源重组通路的缺陷能够增强低氧激活型前体药物CP-506的抗肿瘤效果
Lesley Schuitmaker,Alexander M A van der Wiel,Natasja G Lieuwes et al.
Lesley Schuitmaker et al.
The novel hypoxia-activated prodrug CP-506 selectively targets the hypoxic, treatment-resistant tumor microenvironment. Given the alkylating effector metabolites of CP-506, we hypothesized that defects in interstrand crosslink (ICL) and dou...
The evolving landscape of CAR T cell therapy in children and young adults with B cell acute lymphoblastic leukemia [0.03%]
儿童和年轻成人B细胞急性淋巴细胞白血病的CAR-T细胞治疗现状及展望
Alexandra Dreyzin,Flavia Gava,Chelsea Lamplugh et al.
Alexandra Dreyzin et al.
Chimeric antigen receptor (CAR) T cells have demonstrated remarkable ability to render multiple relapsed and refractory patients into a deep and often durable remission. Since initial FDA approval of tisagenlecleucel in 2017, real-world dat...
Patient-derived lung tumoroids reveal determinants of CAR T cell efficacy in solid tumors [0.03%]
基于患者的肺癌肿瘤样体揭示了实体瘤CAR-T细胞疗效的影响因素
Martí Farrera-Sal,Lukas Ehlen,Michael Schmueck-Henneresse
Martí Farrera-Sal
Reprogramming CXCL10-mediated NK cell trafficking to enhance immunotherapy in osteosarcoma [0.03%]
重塑CXCL10介导的NK细胞趋向性以增强骨肉瘤免疫治疗效果
William P Jayne,Madison E Freilich,Ranjan Solanki et al.
William P Jayne et al.
Beyond phagocytosis: Co-expressing IL-21 to arm CAR-macrophages for systemic anti-tumor immunity [0.03%]
超越吞噬作用：共表达IL-21以武装CAR巨噬细胞并介导全身抗肿瘤免疫反应
Yizhao Chen,Wei Wei,Jiajie Tu
Yizhao Chen
Harnessing oncogenic signaling to enhance oncolytic virotherapy: Lessons from EPAC-encoding vaccinia virus [0.03%]
利用致癌信号促进溶瘤病毒疗法：EPAC编码痘苗病毒的启示
Stephen Boulton,Siddharth Singh,John C Bell
Stephen Boulton
Tien-Ching Chang,John M Warrington,Nathan Singh
Tien-Ching Chang
Antigen-binding affinity is a key determinant of the durable antitumor activity of CD5 CAR-T cells [0.03%]
抗原结合亲和力是CD5 CAR-T细胞持久抗肿瘤活性的关键决定因素
Jeong-Hoon Jeong,Yu Ri Seo,Seung Rok Yu et al.
Jeong-Hoon Jeong et al.
T cell fratricide in T cell antigen-targeted chimeric antigen receptor (CAR)-T cell therapies remains a critical barrier to achieving optimal antitumor efficacy. To address this challenge, we explored modulation of antigen-binding affinity ...
Retinal organoid screening reveals ABT-737 and luminespib as potential agents against a cone- precursor-derived subtype of retinoblastoma [0.03%]
视网膜器官样物筛选发现ABT-737和luminespib可能是针对感光细胞前体衍生的视网膜母细胞瘤亚型的潜在药物
Joe Kelk,Agata Rozanska,Eleni Sotiriadou et al.
Joe Kelk et al.
Retinoblastoma (Rb) features proliferating cone precursors, particularly those in the G2/M phase, as a major driver population revealed by recent single-cell transcriptomic studies, though other molecular subtypes with distinct cellular ori...