Oncolytic virus-delivered GSDME: Unlocking pyroptosis to improve dendritic cell function and amplify cytotoxic T cell response [0.03%]
溶瘤病毒递送的GSDME：解锁焦亡以改善树突状细胞功能并增强细胞毒性T细胞反应
Sabrina Schneider,Theresa Schwaiger,Joelle Kröll et al.
Sabrina Schneider et al.
Oncolytic virotherapy is a promising strategy for advanced cancers, but clinical success remains limited. Combining oncolytic viruses with immunogenic cell death modalities offers a potential solution. Pyroptosis, an inflammatory form of pr...
Natural killer cell-derived extracellular vesicles reprogram cellular human immunity to enhance tumor cytotoxicity [0.03%]
自然杀伤细胞源性外泌体重塑人体免疫细胞活性从而增强肿瘤细胞毒性作用
Frederic St-Denis-Bissonnette,Karan Mediratta,Nicholas Ho et al.
Frederic St-Denis-Bissonnette et al.
Natural killer (NK) cells are part of the body's first line of defense that rapidly destroy stressed, infected, or cancerous cells. These immune cells release nanosized biological packages called extracellular vesicles (EVs), which transfer...
PARP7 inhibitors enhance the immunogenic effects of radiation in pancreatic cancer cells [0.03%]
PARP7抑制剂可增强胰腺癌细胞的放射免疫原性效应
Niccolò Bragato,Ana Beatriz Dias,Anna Ohradanova-Repic et al.
Niccolò Bragato et al.
Pancreatic ductal adenocarcinoma (PDAC) is the most frequent type of pancreatic cancer with a poor prognosis and resistance to conventional radio- and chemotherapy. Radiation can induce pro-inflammatory signaling by activating the type 1 in...
Patient-derived tumor organoids for personalized cancer immunotherapy: An immunopeptidome-to-validation approach in RCC and BC [0.03%]
基于患者的肿瘤类器官在肾癌和膀胱癌的个性化免疫治疗中的应用：从免疫肽组到验证的方法
Gabriella Antignani,Michaela Feodoroff,Jacopo Chiaro et al.
Gabriella Antignani et al.
Immunotherapy has revolutionized cancer treatment, yet clinical success remains limited, with only a fraction of patients responding. Tumor heterogeneity and patient-specificity hinder response prediction, emphasizing the need for human-bas...
Development of chimeric antigen receptors targeting the γδ T cell receptor [0.03%]
针对γδ T细胞受体的嵌合抗原受体开发
Lauren C Cutmore,Norris Lam,Christina Amatya et al.
Lauren C Cutmore et al.
T cell malignancies expressing γδ T cell receptors (TCRs) have poor prognoses. No approved treatments specifically target γδ T cell malignancies. To address this deficiency, we aimed to develop chimeric antigen receptors (CARs) targetin...
Tumoricidal efficacy of DZ-1 dye conjugated to dihydroartemisinin in patient-derived colorectal liver metastasis tumoroids [0.03%]
一种新型光敏剂DZ-1与双氢青蒿素偶联的抗肿瘤效果及其机制研究——以结直肠癌肝转移类器官为模型
Farzaneh Vafaeinik,Badrinath Narayanasamy,Sarah Helmueller et al.
Farzaneh Vafaeinik et al.
Hepatic colorectal metastases, also termed colorectal liver metastases (CRLM), remain a major clinical challenge, despite advances in surgery and chemotherapy. The complexity of CRLM pathology necessitates novel therapeutic approaches, yet ...
mRNA vaccination using peptide nanoparticles triggers a strong immune response against endogenous GPC2 in a murine neuroblastoma model [0.03%]
基于GPC2的多肽纳米粒子诱导的小鼠神经母细胞瘤模型中的强大免疫应答
Ellen King,Chayanika Saha,Rabia Saleem et al.
Ellen King et al.
Neuroblastoma is an aggressive pediatric solid tumor that arises during embryonic development and contributes to 15% of cancer-related deaths in children. To date, neither experimental nor clinical trial data on an mRNA vaccine for neurobla...
AGTR1 signaling contributes to tumor immunity and therapy response in non-small cell lung cancer [0.03%]
非小细胞肺癌中AGTR1信号促进肿瘤免疫和治疗反应
Tatsuki Ikoma,Keigo Araki,Mai Kitagawa et al.
Tatsuki Ikoma et al.
Angiotensin II receptor type 1 (AGTR1) has emerged as a potential modulator of the tumor microenvironment, yet its role in the immunotherapy response in non-small cell lung cancer (NSCLC) remains unclear. We performed a comprehensive analys...
Oncolytic viruses enhance CAR-T activity for the treatment of pediatric diffuse midline gliomas [0.03%]
溶瘤病毒可增强CAR-T细胞对儿童弥漫性中线胶质瘤的治疗作用
Kyung-Don Kang,Zhuo Zhang,Joshua D Bernstock et al.
Kyung-Don Kang et al.
A tri-component organoid model reveals field-cancerized fibroblasts as key drivers of LUAD recurrence and drug resistance [0.03%]
三组分类器官模型揭示了场癌化纤维细胞是LUAD复发和耐药的关键驱动因素
Kun Qiao,Yanhong Huang,Damien Chua et al.
Kun Qiao et al.
Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality, driven by extensive tumor heterogeneity and therapy resistance. Conventional models fail to capture the dynamic interactions between cancer cells and the tumor micro...