A multivariate cell-based liquid biopsy for lung nodule risk stratification: Analytical validation and early clinical evaluation [0.03%]
基于细胞的多重液态活检在肺结节风险分层中的分析验证及临床评估
Jason D Berndt,Fergal J Duffy,Mark D D&#x;Ascenzo et al.
Jason D Berndt et al.
Background: The Indicator Cell Assay Platform (iCAP) is a novel tool for blood-based diagnostics that uses living cells as biosensors to integrate and amplify weak, multivalent disease signals present in patient serum. In...
Next-generation leukemia diagnostics: Integrating LC-MS/MS proteomics with liquid biopsy platforms [0.03%]
下一代白血病诊断技术：液相色谱质谱与液体活检平台的整合
Vivek Singh
Vivek Singh
Diagnosing leukemia often depends on invasive bone marrow biopsies, which can be painful and may fail to detect the early stages of the disease. Liquid biopsy, a minimally invasive method that analyzes circulating biomarkers in blood, has e...
Implementation of circulating tumor DNA (ctDNA) testing in precision oncology: A four-year experience from a tertiary cancer center in India [0.03%]
印度三级癌症中心精准肿瘤学中实施循环肿瘤DNA(ctDNA)检测的四年经验
Pradnya Joshi,Prachi Gogte,Prachi Pawar et al.
Pradnya Joshi et al.
Introduction: Liquid biopsy testing has emerged as a pivotal tool in molecular characterization of solid malignancies. Circulating tumor DNA (ctDNA) analysis is quintessential in precision oncology for early detection, di...
Harmonization trial on ESR1 testing strategies in ER+/HER2- breast cancer patients: an Italian experience [0.03%]
意大利ER+/HER2-乳腺癌患者ESR1检测策略的 harmonization 研究经验
Francesco Pepe,Gianluca Russo,Konstantinos Venetis et al.
Francesco Pepe et al.
Aims: To date, ESR1 activating mutations acts as key player to clinically stratify estrogen receptor (ER)+/HER2-advanced breast cancer (BC) patients eligible to novel new generation oral Selective Estrogen Receptor Degrad...
Diagnostic value of circulating lncRNAs HOTAIR, ANRIL, and MEG3 in oral squamous cell carcinoma and their correlation with clinicopathological features [0.03%]
口腔鳞状细胞癌血循环中的长链非编码RNA（HOTAIR、ANRIL和MEG3）的诊断价值及其与临床病理特征的相关性研究
Farhana Ikram,Poorvi Mathur,Pallavi Dubey et al.
Farhana Ikram et al.
Background: Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related morbidity and mortality worldwide, largely due to late-stage diagnosis and lack of reliable non-invasive biomarkers. Long non-coding RNA...
Circulating biomarkers in HPV-associated oropharyngeal cancer: Clinical applications of liquid biopsy in diagnosis, prognosis, and surveillance [0.03%]
人乳头瘤病毒相关性口咽癌的循环生物标志物：液体活检在诊断、预后和监测方面的临床应用
Swati Kumari,Sridhar Mishra,Wahid Ali
Swati Kumari
Oropharyngeal squamous cell carcinoma (OPSCC), particularly the HPV-associated subtype, represents a growing public health burden worldwide. While HPV-positive OPSCC carries a better prognosis, challenges persist in early detection, treatme...
Analysis of cerebrospinal fluid tumor-derived DNA to obviate biopsy of IDH-mutant brainstem glioma in an adult [0.03%]
分析脑脊液肿瘤衍生DNA以避免成人IDH突变脑干胶质瘤活检
Michael Youssef,Alexandra Larson,Vindhya Udhane et al.
Michael Youssef et al.
Adult brainstem gliomas are rare and present unique diagnostic and therapeutic challenges due to their critical location and limited biopsy feasibility. Molecular profiling of tumor-derived DNA (t-DNA) isolated from cerebrospinal fluid (CSF...
Demonstrating the clinical utility of genomic profiling using cerebrospinal fluid to inform management of central nervous system tumors - a meta analysis of the literature [0.03%]
通过使用脑脊液的基因组谱分析来指导中枢神经系统肿瘤治疗管理的临床应用示范--文献的元分析
Sakshi Khurana,Qian Nie,Kala F Schilter et al.
Sakshi Khurana et al.
Purpose: Meta-analysis of literature was performed to gain an understanding of the performance of genomic profiling assays in cerebrospinal fluid (CSF) for the diagnosis and management of CNS cancers. ...
Maria Luisa Schiavone,Rosa Scarpitta,Francesco Ravera et al.
Maria Luisa Schiavone et al.
Breast cancer (BC) is the most frequent cancer and the leading cause of cancer-related death among women worldwide. It represents a heterogeneous group of diseases with distinct morphological, immunophenotypic, and molecular profiles, which...
Fragmentomic-based algorithm to computationally predict tumor-somatic, germline, and clonal hematopoiesis variant origin in liquid biopsy [0.03%]
基于片段组学的算法可计算预测液体活检中肿瘤体细胞、胚系和克隆造血变异来源
Derek W Brown,Daokun Sun,Alexander D Fine et al.
Derek W Brown et al.
Purpose: Genomic profiling of tumors by liquid biopsy (LBx) is a pragmatic alternative to profiling tissue. Despite recent methodologic advances, clonal hematopoiesis (CH) variants arising from hematopoietic stem cells ma...