Harmonizing definitions in liquid biopsy: A terminology framework by the international society of liquid biopsy [0.03%]
国际液态活检协会的液态活检术语框架：调和定义
Eloísa Jantus-Lewintre,Silvia Calabuig-Fariñas,David Gandara et al.
Eloísa Jantus-Lewintre et al.
The rapid expansion of liquid biopsy (LB) throughout the cancer care continuum is evidenced by the striking increase in annual publications, rising from approximately 100 per year in the early 2000s to more than 2200 in recent years. This e...
The potential survival gain and cost-effectiveness of circulating tumor DNA-guided treatment switching in advanced non-small cell lung cancer: A simulation modeling study [0.03%]
基于循环肿瘤DNA指导的晚期非小细胞肺癌治疗转换的潜在生存效益和成本效益：一项模拟研究
Jeroen P Jansen,Michael P Douglas,Kathryn A Phillips
Jeroen P Jansen
Objective: Circulating tumor DNA (ctDNA) has emerged as a minimally invasive approach to assess treatment response in cancer. While ctDNA response has been associated with greater survival outcomes, the clinical benefit a...
Alexandre Matov
Alexandre Matov
Introduction: The current healthcare system relies largely on a passive approach toward disease detection, which typically involves patients presenting a "chief complaint" linked to a particular set of symptoms for diagno...
Plasma histone monomers as novel diagnostic markers in adult glioblastoma [0.03%]
血浆组蛋白单体作为成人胶质母细胞瘤新型诊断标志物的研究
Desislava K Tsoneva,Diana Buzova,Stefani Mariyanova Todorova et al.
Desislava K Tsoneva et al.
Background: Glioblastoma (GB), the most aggressive primary brain tumor in adults, has a median survival of 12-18 months and lacks reliable minimally invasive biomarkers. Traditional diagnostics are limited by invasiveness...
The incremental value of liquid biopsy in the initial evaluation of patients with metastatic non-small cell lung cancer undergoing tissue-based molecular testing [0.03%]
组织活检分子检测的晚期非小细胞肺癌患者初始评估中液体活检的增量价值
Benjamin A Bleiberg,Dylan G Scholes,Lauren Reed-Guy et al.
Benjamin A Bleiberg et al.
Introduction: Actionable genetic alterations (AGAs) are present in many patients with non-squamous, metastatic non-small cell lung cancer (mNSCLC) and guide the selection of targeted therapies. Guidelines support concurre...
Advancing clinical integration of circulating tumor cells: Outcomes of an international expert consensus [0.03%]
循环肿瘤细胞的临床应用整合进展：国际专家共识结果
Massimo Cristofanilli,M Jose Serrano
Massimo Cristofanilli
Analytical and clinical validation of a novel CE-IVD kit for PIK3CA hotspot mutations in liquid biopsy samples [0.03%]
用于液体活检样本中PIK3CA热点突变新型CE IVD试剂盒的分析及临床验证
Dimitra Stergiopoulou,Stavroula Smilkou,Elena Tzanikou et al.
Dimitra Stergiopoulou et al.
PIK3CA mutations have been implicated in the prognosis and therapeutic response in HER2-positive early breast cancer, with variants located in exon 9 and exon 20 shown to modulate sensitivity to neoadjuvant chemotherapy. Several molecular d...
Direct detection of rare circulating tumor cells in peripheral blood mononuclear cells by scRNA seq: Spike-in strategy based feasibility study [0.03%]
scRNA seq直接检测外周血单个核细胞中稀有循环肿瘤细胞的可行性研究（ Spike-in策略）
Shivam Kumar,Divya Janjua,Udit Joshi et al.
Shivam Kumar et al.
Background: Circulating tumor cells (CTC) provide a minimally invasive window into metastatic disease but are difficult to detect and estimate due to their rarity and heterogeneity. Conventional enrichment-based approache...
Cell-free RNA profiling uncovers non-canonical circulating D2 transcript elevation in Bladder Cancer plasma [0.03%]
无细胞RNA谱分析揭示膀胱癌血浆中非经典循环D2转录本升高现象
Annarita Nappi,Felice Crocetto,Paolo Conforti et al.
Annarita Nappi et al.
Background: D2 overexpression has emerged as a recurrent molecular feature across multiple cutaneous malignancies, where it contributes to aberrant Thyroid Hormone (TH) activation and tumor-associated metabolic reprogramm...
Tissue expression of miR-504-5p and miR-429 as diagnostic biomarkers for endometrial cancer and endometrial intraepithelial neoplasia: a pilot study [0.03%]
miR-504-5p和miR-429组织表达作为子宫内膜癌和子宫内膜上皮内瘤变诊断生物标志物的初步研究
A Manzi,C De Luca,F Conticelli et al.
A Manzi et al.
Introduction: Endometrial cancer (EC) is the sixth most frequent female malignancy worldwide. Atypical endometrial hyperplasia (AEH), also termed endometrial intraepithelial neoplasia (EIN), represents the recognized prec...