Moving liquid biopsies to the Front-line of lung cancer treatment decisions [0.03%]
将液体活检应用于肺癌治疗的前沿决策中
Luis E Raez,Carlos Carracedo,Daniel Rosas et al.
Luis E Raez et al.
Liquid biopsies have evolved as a promising non-invasive technology for cancer diagnosis and treatment, as they provide a comprehensive analysis of tumor-derived biomarkers. Prospective multicenter studies have shown the efficacy of liquid ...
Validity and utility of blood tumor mutational burden (bTMB) is dependent on circulating tumor DNA (ctDNA) shed: SCRUM-Japan MONSTAR-SCREEN [0.03%]
血液肿瘤突变负荷(bTMB)的有效性和效用取决于循环肿瘤DNA(ctDNA)的释放：SCRUM-Japan MONSTAR-SCREEN
Saori Mishima,Yoshiaki Nakamura,Hanna Tukachinsky et al.
Saori Mishima et al.
Background: The tumor mutational burden (TMB) is a genomic biomarker associated with the benefits from immune checkpoint inhibitors (ICIs) cancer therapy. An elevated blood TMB (bTMB) in circulating tumor DNA (ctDNA) repr...
Konstantinos Venetis,Giulia Cursano,Carlo Pescia et al.
Konstantinos Venetis et al.
Breast cancer management has witnessed significant advancements, especially in the diagnosis and treatment response monitoring through the implementation of imaging techniques and tissue biopsy procedures. Nevertheless, there is potential f...
Circulating tumor DNA in clinical trials for solid tumors: Challenges and current applications [0.03%]
循环肿瘤DNA在实体瘤临床试验中的挑战与当前应用
Claudia Parisi,Marco Tagliamento,Laila Belcaid et al.
Claudia Parisi et al.
Tumor derived biomarkers including circulating tumor DNA (ctDNA) and/or circulating tumors cells (CTCs) may be detected and quantified through liquid biopsy (LB). ctDNA analysis through LB is a validated tool for monitoring response to syst...
Rafael Rosell,Mariacarmela Santarpia,Carlos Pedraz-Valdunciel et al.
Rafael Rosell et al.
Lung cancer screening programs, particularly in the UK, have shown a decrease in lung cancer-related deaths among individuals who underwent low-dose computed tomography (CT) screening. Researchers are now focusing on evaluating cell-free DN...
ctDNA-based liquid biopsy reveals wider mutational profile with therapy resistance and metastasis susceptibility signatures in early-stage breast cancer patients [0.03%]
基于 ctDNA 的液态活检揭示了早期乳腺癌患者具有治疗抵抗和转移倾向信号的更广泛的突变谱
Atul Bharde,Snigdha Nadagouda,Manoj Dongare et al.
Atul Bharde et al.
A minimally invasive analysis of plasma cell-free DNA (cfDNA) offers a genomic profiling of early-stage breast cancer (EBC), potentially identifying mutational signatures linked to metastasis and therapy resistance. In this study, paired pl...
PADI4 expression in baseline circulating tumour cells acts as a prognostic biomarker in oral squamous cell carcinoma [0.03%]
基线循环肿瘤细胞中PADI4的表达可作为口腔鳞状细胞癌的预后生物标志物
Anshika Chauhan,Geeta S Boora,Arindam Maitra et al.
Anshika Chauhan et al.
Oral Squamous Cell Carcinoma (OSCC), one of the most prevalent cancers in developing countries. It is associated with poor prognosis due to relapse in a significant number of patients. Circulating tumour cells (CTCs) are precursors for meta...
Genomic characterization of metastatic patterns in prostate cancer using circulating tumor DNA data from the SCRUM-Japan MONSTAR SCREEN project [0.03%]
使用SCRUM-Japan MONSTAR SCREEN项目中的循环肿瘤DNA数据对前列腺癌转移模式进行基因组特征分析
Masaki Shiota,Nobuaki Matsubara,Taigo Kato et al.
Masaki Shiota et al.
Purpose: Genomic characterization of the predisposition of tumors to metastasize to specific sites has been performed in a few studies using mainly tissue-derived genomes. This nationwide prospective observational study i...
The role of molecular biomarkers in the diagnosis, prognosis, and treatment stratification of oral squamous cell carcinoma: A comprehensive review [0.03%]
分子生物标志物在口腔鳞状细胞癌的诊断，预后和治疗分层中的作用：全面综述
Saravanan Ravindran,Srinivasan Ranganathan,Karthikeyan R et al.
Saravanan Ravindran et al.
One of the most common cancers targeting the area of the head and neck is oral squamous cell carcinoma (OSCC), carrying a heavy global health cost. With a high incidence of metastasis and recurrence, the outlook for OSCC remains dismal desp...
Potential applications of gene expression profiles obtained from circulating extracellular vesicles in breast cancer [0.03%]
循环胞外囊泡获得的基因表达谱在乳腺癌中的潜在应用
Aritra Gupta,Siddharth Bhardwaj,Sayan Ghorai et al.
Aritra Gupta et al.
Background: Liquid biopsy-based biomarkers offer several advantages since they are minimally invasive, can be useful in longitudinal monitoring of the disease and have higher patient compliance. We describe a protocol usi...