Matthew Gittus,Tess Harris,Albert Cm Ong
Matthew Gittus
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease. It has been associated with a significant physical and psychological burden, leading to a reduced quality of life. The purpose of this literat...
Alan S L Yu,Douglas P Landsittel
Alan S L Yu
This article describes the use of prognostic, predictive, and response biomarkers that have been developed for autosomal dominant polycystic kidney disease and their use in clinical care or drug development. We focus on biochemical markers ...
Drug Development in Autosomal Dominant Polycystic Kidney Disease: Opportunities and Challenges [0.03%]
常染色体显形多囊肾病的药物研发：机遇与挑战
Fouad T Chebib,Ronald D Perrone
Fouad T Chebib
Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder characterized by relentless growth of innumerable renal cysts bilaterally, associated with decline in glomerular filtration rate over the course of decades. The b...
Autosomal Dominant Polycystic Kidney Disease Therapies on the Horizon [0.03%]
未来 autosomal显性的多囊肾疾病的治疗
Julie Xia Zhou,Vicente E Torres
Julie Xia Zhou
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of numerous kidney cysts which leads to kidney failure. ADPKD is responsible for approximately 10% of patients with kidney failure. Overwhelming evidence...
Autosomal Dominant Polycystic Kidney Disease in Children and Adolescents: Assessing and Managing Risk of Progression [0.03%]
儿童和青少年常染色体显性多囊肾病：评估和管理疾病进展风险
Angélique Dachy,Liselotte Van Loo,Djalila Mekahli
Angélique Dachy
The clinical management of autosomal dominant polycystic kidney disease (ADPKD) in adults has shifted from managing complications to delaying disease progression through newly emerging therapies. Regarding pediatric management of the diseas...
William Ackley,Neera K Dahl,Meyeon Park
William Ackley
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disorder and the fourth leading cause of end-stage kidney disease. ADPKD encompasses a wide range of morbidity in addition to chronic kidney disease and ...
Nonpharmacological Management of Autosomal Dominant Polycystic Kidney Disease [0.03%]
常染色体显性多囊肾病的非药物治疗
Cortney N Steele,Kristen L Nowak
Cortney N Steele
Autosomal dominant polycystic kidney disease is a slowly progressive, lifelong disease characterized by continuous development and enlargement of kidney cysts. Thus, nonpharmacological interventions are crucial in disease management and hav...
Jiahe Qiu,Gregory G Germino,Luis F Menezes
Jiahe Qiu
Autosomal dominant polycystic kidney disease is the most common inherited cause of end-stage kidney disease worldwide. Most cases result from mutation of either of 2 genes, PKD1 and PKD2, which encode proteins that form a probable receptor/...
Hyponatremia Demystified: Integrating Physiology to Shape Clinical Practice [0.03%]
解密低钠血症：整合生理学重塑临床实践
Biruh T Workeneh,Priti Meena,Mirjam Christ-Crain et al.
Biruh T Workeneh et al.
Hyponatremia is one of the most common problems encountered in clinical practice and one of the least-understood because accurate diagnosis and management require some familiarity with water homeostasis physiology, making the topic seemingl...