Varsha Suresh,Isaac E Stillman,Kirk N Campbell et al.
Varsha Suresh et al.
Focal segmental glomerular sclerosis (FSGS) is a histological lesion characterized by sclerosis in sections (segmental) of some glomeruli (focal) in association with podocyte injury. Historically, FSGS has often been characterized as a dise...
Minimal Change Disease [0.03%]
最小改变疾病
Alexis C Gomez,Keisha L Gibson,Harish Seethapathy
Alexis C Gomez
Minimal change disease represents a common cause of nephrotic syndrome in both pediatric and adult patients. Although much remains to be discovered, there have been significant recent advancements in our understanding of the pathophysiology...
Anuja Java,Richard Burwick,Anthony Chang
Anuja Java
Thrombotic microangiopathy (TMA) is a pathological lesion that occurs due to endothelial injury. It can be seen in a heterogenous group of disorders, typically characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end-or...
Ryan W Bonner,Vanessa Moreno,Koyal Jain
Ryan W Bonner
The nephritic syndrome has been associated with a wide variety of infections, spanning many organisms and myriad clinical presentations. Infection-associated glomerulonephritis is challenging to diagnose given the many confounding factors l...
A Comprehensive and Practical Approach to the Management of Lupus Nephritis in the Current Era [0.03%]
当前系统性红斑狼疮肾炎管理的实用综合策略
Nasim Wiegley,Swati Arora,Sayna Norouzi et al.
Nasim Wiegley et al.
Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) and is one of the leading causes of morbidity and mortality in patients with SLE. It is estimated that up to 60% of individuals with SLE will develop LN, wh...
Benjamin Wooden,Carla M Nester,Andrew S Bomback
Benjamin Wooden
C3 glomerulopathy (C3G) is a rare disorder marked by deposition of C3 in the glomerulus, resulting in damage to the glomerular filtration unit and presenting with features of the nephritic and nephrotic syndromes. Fundamentally, C3G is caus...
Samuel Mon-Wei Yu,Margaret Deoliveira,Miriam Chung et al.
Samuel Mon-Wei Yu et al.
Membranoproliferative glomerulonephritis (MPGN) is no longer a disease but a pattern of injury in various diseases. Characterized by electron-dense deposits, mesangial proliferation, and duplication of the glomerular basement membrane, MPGN...
Joyita Bharati,Kenar D Jhaveri,Alan D Salama et al.
Joyita Bharati et al.
Anti-glomerular basement membrane disease is a small-vessel vasculitis involving the kidneys (∼90%) and the lungs (∼60%). Antibodies against the glomerular basement membrane are directly pathogenic in anti-glomerular basement membrane dis...
Purva Sharma,Reza Zonozi,Duvuru Geetha
Purva Sharma
ANCA-associated vasculitis (AAV) is a necrotizing, small-to-medium vessel vasculitis associated with significant morbidity and mortality. AAV is a systemic autoimmune disease affecting kidneys, eyes, sinuses, peripheral nerves, skin, and up...
Haresh Selvaskandan,Kenar D Jhaveri,Dana V Rizk
Haresh Selvaskandan
Primary IgA nephropathy (IgAN) is a common glomerular disorder defined by predominant mesangial IgA deposition. Once thought to follow a progressive course in 10-20% of those diagnosed, emerging evidence now suggests most will progress to k...