ICU Implementation Determinants and Delivery of Lung Protective Ventilation: A Multihospital Survey and Cohort Study [0.03%]
ICU实施决定因素和肺保护性通气的提供：多医院调查和队列研究
Chad H Hochberg,Sophia A Emetu,Kevin J Psoter et al.
Chad H Hochberg et al.
Background: Lung protective ventilation (LPV) improves mortality in patients with ARDS and is applied widely in other patients receiving mechanical ventilation. Despite strong evidence, LPV is implemented inconsistently. ...
The Use of the Rox Index to Guide High-Flow Nasal Cannula Therapy and the Need for Intubation Is Associated With Meaningful Patient Outcomes [0.03%]
Rox指数指导高流量鼻导管吸氧及机械通气的临床意义分析
Jonathan Taylor,Aaron Gans,Taylor Treacy et al.
Jonathan Taylor et al.
Background: Acute hypoxemic respiratory failure (AHRF) is a common and life-threatening condition frequently managed with high-flow nasal cannula (HFNC) oxygenation. The ROX index, the ratio of oxygen saturation to FIO2 t...
The Challenges of Prognosticating Persistent Critical Illness: A Qualitative Study [0.03%]
重症患者预后预测的挑战：定性研究
Kaitland M Byrd,Madeline M Lagina,Kathleen T Lee et al.
Kaitland M Byrd et al.
Background: Medical decision-making in the ICU is influenced by a patient's anticipated clinical course. However, intensivists struggle to identify accurately which patients will experience within-ICU events-such as new l...
A Computable Electronic Health Record ARDS Classifier and the Association Between the MUC5B Promoter Polymorphism and ARDS in Critically Ill Adults [0.03%]
ARDS电子病历分类器的开发及MUC5B启动子多态性与危重患者ARDS的相关性研究
V Eric Kerchberger,J Brennan McNeil,Neil Zheng et al.
V Eric Kerchberger et al.
Background: Large population-based DNA biobanks linked to electronic health records (EHRs) may provide novel opportunities to identify genetic drivers of ARDS. ...
Ascorbate for Organ Dysfunction in Critically Ill Patients With Sepsis: The Phase 2b ASTER Trial [0.03%]
维生素C辅助治疗脓毒症危重患者的器官功能障碍：ASTER二期临床试验结果
D Clark Files,Michael A Matthay,Lorraine B Ware et al.
D Clark Files et al.
Background: A phase 2 trial of high-dose IV ascorbate suggested reduced mortality in patients with ARDS, although trials in sepsis have failed to show clinical benefit. ...
Association Between Receipt of Ketamine vs Etomidate for Emergency Tracheal Intubation and Symptoms of Posttraumatic Stress Disorder at 12 Months [0.03%]
急诊气管插管时使用氯胺酮与依托咪酯对12个月后创伤后应激障碍症状的影响：一项随机临床试验
Lucas C Wollenman,Austin M Tipold,Matthew W Semler et al.
Lucas C Wollenman et al.
Background: One of 3 patients in the ICU receiving mechanical ventilation demonstrates posttraumatic stress disorder (PTSD). A single dose of ketamine has been shown to reduce PTSD symptoms in outpatients with chronic PTS...
Exploring Racial Differences in Family Expressions of Emotion and Clinician Empathy in ICU Family Meetings [0.03%]
不同种族家庭成员在ICU家属会议中表达情感情况及临床医生换位思考能力的探究
Matthew E Modes,Deborah B Ejem,Whitney Welsh et al.
Matthew E Modes et al.
Background: Critical care guidelines recommend that clinicians provide emotional support to families of critically ill patients during family meetings. Little is known about how family member race impacts how emotions are...
Protocol and Statistical Analysis Plan for the Vasopressin for Septic Shock Pragmatic (VASSPR) Cluster-Crossover Randomized Trial [0.03%]
血管加压素治疗脓毒性休克实用簇交叉随机试验方案及统计分析计划(VASSPR试验)
Ithan D Peltan,Danielle Groat,Jason R Jacobs et al.
Ithan D Peltan et al.
Background: Guidelines recommend vasopressin as the preferred second-line vasopressor for treatment of septic shock. However, the optimal threshold for vasopressin initiation is unclear. ...
Developing Core Outcome (Measurement) Sets for Critical Care Research Using the Modified Delphi Method: A Narrative Review [0.03%]
运用改良德尔菲法进行核心结果（测量）集以供重症监护研究的开发：综述文章
Sarah L Gorst,Diana C Bouhassira,Alison E Turnbull
Sarah L Gorst
Topic importance: High-quality core outcome sets (COSs) and core outcome measurement sets (COMSs) can help to optimize research by allowing the results of clinical trials to be compared and combined in systematic reviews....
Protocol and Statistical Analysis Plan for a Multicenter Randomized Trial of Ketamine vs Etomidate for Emergency Tracheal Intubation [0.03%]
有关紧急气管插管用药的多中心随机试验方案及统计分析计划（氯胺酮与依托咪酯）
Stephanie C DeMasi,Brant Imhoff,Ariel A Lewis et al.
Stephanie C DeMasi et al.
Background: Emergency tracheal intubation is a common and high-risk procedure. Ketamine and etomidate are medicines commonly used to induce anesthesia for emergency tracheal intubation, but whether the induction medicatio...