Mevalonate pathway in pancreatic ductal adenocarcinoma: Mechanisms driving metabolic and cellular plasticity [0.03%]
胰腺导管腺癌中的甲戊酸途径：驱动代谢和细胞可塑性的机制
Jenna N Duttenhefner,Katie M Reindl
Jenna N Duttenhefner
The mevalonate pathway plays a crucial role in the metabolic reprogramming of pancreatic ductal adenocarcinoma (PDAC), driving lipid biosynthesis, redox homeostasis, and oncogenic signaling, thereby sustaining tumor progression and therapeu...
Vivek Kumar Dhiman,Manju Kumari,Devendra Singh
Vivek Kumar Dhiman
Despite significant advances in cancer diagnosis and therapy, the global burden of cancer continues to escalate, characterized by increasing incidence and mortality rates. A problem for successful treatment is chemoresistance, which undermi...
Methionine restriction for cancer therapy: From preclinical studies to clinical trials [0.03%]
蛋氨酸限制在癌症治疗中的作用：从临床前研究到临床试验
Nagaraju Bandaru,Shaik Mohammad Noor,Maha Lakshmi Kammili et al.
Nagaraju Bandaru et al.
Methionine restriction (MR) has shown significant promise in cancer therapy because it targets the unique methionine dependency of many tumors. However, despite extensive research on MR, a clear synthesis of preclinical findings and their t...
Arthropod venom peptides: Pioneering nanotechnology in cancer treatment and drug delivery [0.03%]
节肢动物毒液肽在癌症治疗和药物递送中的纳米技术研究进展
Sara K Ghodeif,Nadia A El-Fahla,Mohamed A Abdel-Rahman et al.
Sara K Ghodeif et al.
Cancer is the second leading cause of death globally, claiming >10 million lives in 2020 and a projected increase to 13 million by 2030. Traditional treatments such as chemotherapy, radiation, and surgery can be effective but often lead to ...
Trastuzumab deruxtecan in advanced breast cancer patients with brain metastases or leptomeningeal metastases [0.03%]
T-DXd治疗伴有脑或脑膜转移的晚期乳腺癌患者
Jinsong Liu,Liuliu Quan,Die Sang et al.
Jinsong Liu et al.
•Trastuzumab deruxtecan showed superior intracranial overall response rate (ORR) and median progression-free survival (mPFS) than controls in both stable and active brain metastases.•DEBBRAH, TUXEDO-1, and DESTINY-Breast 12 confirm durabl...
Insights into the biological features and improved diagnostics of adult acute myeloid leukemia via fusion genes identified through targeted next-generation sequencing [0.03%]
通过靶向高通量测序鉴定融合基因对成人急性髓系白血病的生物学特征及改善诊断的启示
Wei Guan,Ketao Wang,Yangliu Shao et al.
Wei Guan et al.
Background: Fusion genes play a crucial role in the pathogenesis of acute myeloid leukemia (AML). This study investigated the utility of targeted next-generation sequencing (NGS) of RNA for detecting rare and unknown fusi...
Neuroendocrine prostate cancer (NEPC)-associated CEP55 promotes cisplatin resistance in prostate cancer by regulating CDK1 phosphorylation [0.03%]
神经内分泌前列腺癌(NEPC)相关CEP55通过调节CDK1磷酸化促进前列腺癌顺铂耐药性
Zhuocheng Lai,Chenxi Hu,Jirong Jie et al.
Zhuocheng Lai et al.
Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of castration-resistant prostate cancer (CRPC) that is typically resistant to nearly all current therapies. In this study, single-cell RNA sequencing (scRNA-seq) and dataset ana...
Safety and efficacy of Cisplatin in combination with Sintilimab and Niraparib in patients with advanced solid tumors: A phase Ib study [0.03%]
信迪利单抗联合尼拉帕利和顺铂治疗晚期实体瘤患者Ib期研究的安全性和有效性
Haitao Tao,Yining Liu,Lijie Wang et al.
Haitao Tao et al.
Background: Immune checkpoint inhibitors combined with PARP inhibitors and chemotherapy can enhance anti-tumor activity. This phase Ib clinical study was designed to evaluate the safety and efficacy of cisplatin in combin...
Clotrimazole as a new frontier: Drug repurposing and its efficacy in cancer therapy [0.03%]
克霉唑在癌症治疗中的新用途及疗效研究
Shubham C Karpe,Manjula Kiran,Sukhen Majhi et al.
Shubham C Karpe et al.
Cancer, ranging from early stages to metastatic spread, is one of the leading causes of death globally. Current treatment options, including chemotherapy, radiotherapy, and targeted drugs, have limitations, such as significant side effects,...
Emerging risk factors and the role of gut microbiota in immunomodulation and therapeutic implications in colorectal cancer [0.03%]
新兴风险因素及肠道菌群在免疫调节和治疗中的作用及其对结直肠癌的影响
Sonakshi Modeel,Sneha Siwach,Padma Dolkar et al.
Sonakshi Modeel et al.
The pathophysiology of many ailments, including neurological, gastrointestinal, and metabolic problems, is well known to be influenced by intestinal dysbiosis. Clinical research has provided evidence suggesting a strong correlation between ...