Theories behind Bacillus Calmette-Guérin failure in high-risk non-muscle-invasive bladder cancer and update on current management [0.03%]
卡介苗对高危非肌层浸润性膀胱癌疗效不佳的理论及其当前治疗策略更新
Hanna Maroof,Louise Paramore,Ahmed Ali
Hanna Maroof
Bladder cancer encapsulates a wide spectrum of disease severities, with non-muscle invasive bladder cancer (NMIBC) representing an entirely different entity from muscle-invasive disease. Bacillus Calmette-Guérin (BCG) is one of the most su...
Efficacy and safety of utidelone for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer who have failed standard second-line treatment: A phase 2 clinical trial (BG01-1801) [0.03%]
乌蒂德隆治疗标准二线疗法失败的局部晚期或转移性非小细胞肺癌患者的疗效和安全性：一项二期临床试验（BG01-1801）
Yuankai Shi,Gongyan Chen,Yanqiu Zhao et al.
Yuankai Shi et al.
Background: Chemotherapy remains the standard-of-care for many patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC), but acquired resistance presents challenges. The aim of this open-label, mult...
Next-generation sequencing reveals relapse and leukemia-free survival risks in newly diagnosed acute myeloid leukemia treated with CAG regimen combined with decitabine [0.03%]
二代测序揭示了新诊断的急性髓系白血病在CAG方案联合地西他滨治疗后的复发风险及无白血病生存期的风险
Sai Huang,Peng Chen,Lu Wang et al.
Sai Huang et al.
Background: Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy whose prognosis is associated with several biomarkers. Decitabine, a deoxyribonucleic acid (DNA) methyltransferase (DNMT) inhibitor, com...
Risk of interstitial lung disease with the use of programmed cell death 1 (PD-1) inhibitor compared with programmed cell death ligand 1 (PD-L1) inhibitor in patients with breast cancer: A systematic review and meta-analysis [0.03%]
乳腺癌患者使用程序性细胞死亡配体1（PD-L1）抑制剂相较于程序性死亡受体1（PD-1）抑制剂发生间质性肺疾病的风险：系统评价和 Meta 分析
Lijuan Guo,Xiaoyi Lin,Xin Lin et al.
Lijuan Guo et al.
Background: Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors have become integral elements within the current landscape of breast cancer treatment modalities; however, they are associat...
Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis [0.03%]
血红素诱导的结肠癌变中血红素氧合酶-1作为潜在促癌因素的病理意义
Rachitha Singhabahu,Sujani M Kodagoda Gamage,Vinod Gopalan
Rachitha Singhabahu
The significance of the heme-metabolizing enzyme heme oxygenase-1 (HMOX1) in the pathogenesis of colorectal cancer (CRC) has not been fully explored. HMOX1 cytoprotection is imperative to limit oxidative stress. However, its roles in preven...
Effects of aspirin on colon cancer using quantitative proteomic analysis [0.03%]
定量蛋白质组分析阿司匹林对结肠癌的影响
Yan Zhang,Haitao Sun,Yu Ji et al.
Yan Zhang et al.
Background: Colon cancer is one of the most prevalent digestive cancers worldwide. Results of epidemiological, experimental, and clinical studies suggest that aspirin inhibits the development of colon cancer. This study a...
Self-healing hydrogels for enhancing chemotherapy drug efficacy: Advancements in anti-sarcoma and carcinoma therapies and clinical trial feasibility [0.03%]
用于增强化疗药物疗效的自修复水凝胶在抗肉瘤和癌疗法及临床试验可行性方面的进展
Luc Taylor
Luc Taylor
•Site-specific administration is key for optimizing anticancer drug administration; self-healing hydrogels may allow this at reasonable costs and reproducibility.•Self-healing hydrogels have several real-world therapeutic applications, in...
Zining Wang,Lu Sun,Yue Wang et al.
Zining Wang et al.
Clinical features and prognostic analysis of the blastoid variant of mantle cell lymphoma: An analysis of 20 patients from two centers [0.03%]
绵羊状滤泡中心淋巴瘤的变种临床特点和预后分析--来自两家治疗中心的20例病人数据分析
Sai Huang,Shaomei Liu,Hongmei Jing et al.
Sai Huang et al.
Zihao Liu,Shanshan Dong,Mengjie Liu et al.
Zihao Liu et al.
Brain metastases are a leading cause of cancer-related mortality. However, progress in their treatment has been limited over the past decade, due to an incomplete understanding of the underlying biological mechanisms. Employing accurate in ...