High wall shear stress-dependent podosome formation in a novel murine model of intracranial aneurysm [0.03%]
一种新的颅内动脉瘤小鼠模型中的高剪切应力依赖性podosomes形成
Jiayi Lu,Mengjun Dai,Yuanqing Yan et al.
Jiayi Lu et al.
High wall shear stress (HWSS) contributes to intracranial aneurysm (IA) development. However, the underlying molecular mechanisms remain unclear, in part due to the lack of robust animal models that develop IAs in a HWSS-dependent manner. T...
The profile of inflammatory extracellular vesicles in intracerebral hemorrhage patients [0.03%]
脑出血患者炎症细胞外囊泡的特征分析
Harshal Sawant,Trevor Bihl,Doan Nguyen et al.
Harshal Sawant et al.
Background: Intracerebral hemorrhage (ICH) is one of the leading life-threatening types of strokes with high mortality. A prominent feature of ICH is neuroinflammation involving leukocytes, such as neutrophils and macroph...
Financial analysis of a locomotor exercise trial for post-stroke recovery: insights from the HIT Stroke Trial [0.03%]
步进运动试验在中风后恢复中的经济分析:HIT中风试验的启示
Emily M Hazen,Bria L Bartsch,Sandra A Billinger
Emily M Hazen
Background: Navigating the complexities of post-stroke recovery trials requires addressing challenges in participant recruitment and retention and effective resource management to ensure trial success. The aim of this stu...
Youngran Kim,Maria A Parekh,Xiaojin Li et al.
Youngran Kim et al.
Background: COVID-19 has emerged as an independent risk factor for stroke. We aimed to determine age and sex-specific stroke incidence and risk factors with COVID-19 in the US using a large electronic health record (EHR) ...
Compromised endothelial progenitor cell exosomal communication with endothelial cells in hypertension ischemia conditions [0.03%]
高血压缺血条件下内皮祖细胞源外泌体与内皮细胞通讯的障碍
Shuzhen Chen,Venkata Polaki,Ji C Bihl et al.
Shuzhen Chen et al.
We have previously demonstrated that endothelial progenitor cell (EPC) derived exosomes (EPC-EXs) can protect endothelial cells (ECs) against hypoxia injury. Given that EX function varies upon the cellular status and EPC function is decline...
Subarachnoid hemorrhage-associated brain injury and neurobehavioral deficits are reversed with synthetic adropin treatment through sustained Ser1179 phosphorylation of endothelial nitric oxide synthase [0.03%]
合成的adropin通过持续的内皮型一氧化氮合酶Ser1179磷酸化治疗蛛网膜下腔出血相关性脑损伤和神经行为缺损
William S Dodd,Devan Patel,Dimitri Laurent et al.
William S Dodd et al.
Background: Subarachnoid hemorrhage (SAH) is a life-threatening vascular condition without satisfactory treatment options. The secreted peptide adropin is highly expressed in the human brain and has neuroprotective effect...
Neurocognitive impairment in Ugandan children with sickle cell anemia compared to sibling controls: a cross-sectional study [0.03%]
乌干达镰状细胞贫血患儿与兄弟姐妹对照组的神经认知功能损害情况：一项横断面研究
Paul Bangirana,Amelia K Boehme,Annet Birabwa et al.
Paul Bangirana et al.
Introduction: The neurocognitive functions in Ugandan children aged 1-12 years with sickle cell anemia (SCA) were compared to their non-SCA siblings to identify risk factors for disease-associated impairment. ...
Adenosine A1R/A3R agonist AST-004 reduces brain infarction in mouse and rat models of acute ischemic stroke [0.03%]
腺苷A1R / A3R激动剂AST-004可减少急性缺血性卒中小鼠和大鼠模型的脑梗死区域
Elizabeth S Fisher,Yanan Chen,Mikaela M Sifuentes et al.
Elizabeth S Fisher et al.
Acute ischemic stroke (AIS) is the second leading cause of death globally. No Food and Drug Administration (FDA) approved therapies exist that target cerebroprotection following stroke. Our group recently reported significant cerebroprotect...
Genomic risk scores and oral contraceptive-associated ischemic stroke risk: a call for collaboration [0.03%]
基因风险评分与口服避孕药相关性脑卒中的风险：合作的呼吁
Forrest Lin,Liisa Tomppo,Brady Gaynor et al.
Forrest Lin et al.
Background: Oral contraceptives (OCs) are generally safe but vascular risk factors increase OC-associated ischemic stroke risk. We performed a case-control study to evaluate whether a genomic risk score for ischemic strok...
Alpha globin gene copy number and incident ischemic stroke risk among Black Americans [0.03%]
美国非裔人群α-珠蛋白基因拷贝数与缺血性卒中的关系
A Parker Ruhl,Neal Jeffries,Yu Yang et al.
A Parker Ruhl et al.
Introduction: People with African ancestry have greater stroke risk and greater heritability of stroke risk than people of other ancestries. Given the importance of nitric oxide (NO) in stroke, and recent evidence that al...