Genomic modifications for enhanced antibiotic production in rifamycin derivative-producing Amycolatopsis mediterranei S699 strains: focusing on rifQ and rifO genes [0.03%]
链霉土壤芽孢杆菌S699菌株产生瑞夷霉素衍生物的基因组学改良：着重于rifQ和rifO基因以提高抗生素产量
Moritz Müller,Elena Bialas,Irina Sturm et al.
Moritz Müller et al.
Rifamycin and its derivatives are natural products that belong to the class of antibiotic-active polyketides and have significant therapeutic relevance within the therapy scheme of tuberculosis, a worldwide infectious disease caused by Myco...
Pharmacokinetic/pharmacodynamic issues for optimizing treatment with beta-lactams of Gram-negative infections in critically ill orthotopic liver transplant recipients: a comprehensive review [0.03%]
优化β-内酰胺类抗生素治疗重症肝移植受者革兰阴性菌感染的药代动力学/药效学问题：全面综述
Milo Gatti,Federico Pea
Milo Gatti
Orthotopic liver transplant (OLT) represents the standard of care for managing patients affected by end-stage and life-threatening liver diseases. Although a significant improvement in surgical techniques, immunosuppressant regimens, and pr...
Repurposing Inhibitors of Phosphoinositide 3-kinase as Adjuvant Therapeutics for Bacterial Infections [0.03%]
将磷脂酶3激酶的抑制剂重新配制为细菌感染的辅助治疗药物
Renee Fleeman
Renee Fleeman
The rise in antimicrobial resistance and the decline in new antibiotics has created a great need for novel approaches to treat drug resistant bacterial infections. Increasing the burden of antimicrobial resistance, bacterial virulence facto...
Antimicrobial resistance control activities at a tertiary hospital in a low-resource setting: an example of Queen Elizabeth Central Hospital in Malawi [0.03%]
马拉维齐尔维亚中央医院抗菌药物管理活动示例——一家资源匮乏的三级医疗机构的经验
Patrick Kamalo,Pui-Ying Iroh Tam,Thokozani Noniwa et al.
Patrick Kamalo et al.
Background: Addressing AMR has been most problematic in low- and middle-income countries, which lack infrastructure, diagnostic capacity, and robust data management systems, among other factors. The implementation of loca...
Jonathan I Batchelder,Patricia J Hare,Wendy W K Mok
Jonathan I Batchelder
Antibiotic resistance is a major danger to public health that threatens to claim the lives of millions of people per year within the next few decades. Years of necessary administration and excessive application of antibiotics have selected ...