Stigmatization and resilience in inflammatory bowel disease patients at one-year follow-up [0.03%]
炎症性肠病患者一年后的病耻感与复原力
Marco Vincenzo Lenti,Giacomo Broglio,Caterina Mengoli et al.
Marco Vincenzo Lenti et al.
Introduction: Inflammatory bowel disease (IBD), namely ulcerative colitis and Crohn's disease, is a chronic relapsing immune-mediated condition that may cause an impairment of social functions due to stigmatisation. Resil...
Future of Colorectal Cancer Screening: From One-Size-FITs-All to Tailor-Made [0.03%]
结直肠癌筛查的未来：“量体裁衣”代替“一刀切”
Tim Kortlever,Manon van der Vlugt,Evelien Dekker
Tim Kortlever
Screening for colorectal cancer (CRC) and its precursor lesions, advanced adenomas (AA), has been shown to effectively reduce CRC-related mortality. However, the method of CRC screening varies among countries. Primary colonoscopy screening ...
Current and future aspects of IBD research and treatment: The 2022 perspective [0.03%]
当前和未来的炎症性肠病研究和治疗状况：2022年展望
Eduard F Stange
Eduard F Stange
Inflammatory bowel diseases (IBD) have seen major progress in current concepts and treatment regimes. Based on the theory of an inadequate "overshoot" of the mucosal immune response to the intestinal microbiome, therapies have been develope...
Modulation of tumor environment in colorectal cancer - could gut microbiota be a key player? [0.03%]
肠道微生物群是否是调节结直肠癌肿瘤微环境的关键因素？
Ana Duarte Mendes,Rodrigo Vicente,Marina Vitorino et al.
Ana Duarte Mendes et al.
The treatment paradigm of neoplastic diseases has dramatically shifted with the introduction of immune checkpoint inhibitors (ICI). They induce a durable response in a wide variety of solid tumors, but this response depends on the infiltrat...
Liver transplantation combined with tyrosine kinase inhibitors for the treatment of hepatic metastatic giant gastrointestinal stromal tumors: A case report and literature review [0.03%]
肝移植联合酪氨酸激酶抑制剂治疗巨大型胃肠间质瘤肝转移1例及相关文献复习
Jun Lin Qian,Ze Min Hu,Kun He et al.
Jun Lin Qian et al.
Background: Surgical resection combined with oral tyrosine kinase inhibitors(TKI) is the most effective treatment for gastrointestinal stromal tumor(GIST) liver metastases. Liver transplantation (LT) is the last resort fo...
Associations of dietary, lifestyle, and other participant characteristics with APC, β-catenin, E-cadherin, and MSH2 expression in the normal mucosa of sporadic colorectal adenoma patients [0.03%]
散发性结直肠腺瘤患者的正常黏膜中APC、β-连环蛋白、E-钙粘着蛋白和MSH2表达与饮食、生活方式及其他受试者特征的关系
Timothy D Shu,Robin E Rutherford,March E Seabrook et al.
Timothy D Shu et al.
Abnormal expression of Wnt pathway and DNA mismatch repair proteins is common during colorectal carcinogenesis. To investigate cross-sectional associations of lifestyle, dietary, and other participant characteristics with the expression of ...
Healthcare resource utilization in Hepatitis C-infected patients completing eight versus twelve weeks of treatment: A retrospective cohort study [0.03%]
完成8周与12周疗程的丙型肝炎病毒感染者医疗资源利用率回顾性队列研究
Katia E Valdez,Marjan Javanbakht,Kori Keith et al.
Katia E Valdez et al.
Background: The objective of this study was to examine differences in healthcare utilization among patients receiving eight vs. 12-weeks of treatment for infection with the Hepatitis C Virus (HCV). ...
European Registry on Helicobacter pylori Management (Hp-EuReg): Most relevant results for clinical practice [0.03%]
欧洲Hp管理注册登记(Hp-EuReg):临床实践的最重要结果
Olga P Nyssen,Leticia Moreira,Natalia García-Morales et al.
Olga P Nyssen et al.
Background: The ideal treatment approach for H. pylori infection has not yet been defined; therefore, the most effective management strategies for adult patients need to be identified to ensure clinical practice is aligne...
Innovative, complementary and alternative therapy in inflammatory bowel diseases: A broad 2020s update [0.03%]
创新的、补充和替代疗法在炎症性肠病中的应用：2020年代综述更新
Letizia Masi,Cristina Ciuffini,Valentina Petito et al.
Letizia Masi et al.
Inflammatory bowel diseases (IBD) are chronic disabling conditions with a complex and multifactorial etiology, which is still not completely understood. In the last 20 years, anti-TNF-α antagonists have revolutionized the treatment of IBD,...
Gut microbiota in anxiety and depression: Pathogenesis and therapeutics [0.03%]
肠道微生物组在焦虑和抑郁中的发病机制与治疗作用
Stefano Bibbò,Salvatore Fusco,Gianluca Ianiro et al.
Stefano Bibbò et al.
Depression and anxiety disorders represent a burdensome clinical issue. Considering the unsatisfactory clinical response of some patients to antidepressant therapy, new personalized approaches are being studied. In recent years, pre-clinica...