Enzyme-triggered peptide assembly boosts dental stem cell osteogenic differentiation by enhancing osteogenic pentapeptide accumulation [0.03%]
酶触发的肽组装通过增强成骨五肽积累来促进牙髓干细胞成骨分化
Zhe Yu,Xiaoying Liu,Yao Du et al.
Zhe Yu et al.
Tooth regeneration and bone tissue repair represent significant challenges in oral surgery, and osteogenic differentiation is crucial with respect to dental implant osseointegration and bone healing. Studies have reported that osteogenic gr...
A four-pronged approach to unleash the regenerative potential of extracellular vesicles for bone regeneration: A systematic review of in vitro and in vivo studies [0.03%]
释放外泌体骨再生潜能的四管齐下方法：体内外研究的系统性回顾
Shayan Salehy,Hanieh Nokhbatolfoghahaei,Arash Khojasteh
Shayan Salehy
The clinical application of Extracellular vesicles for bone regeneration faces several key challenges, including low production yield and potency, a lack of standardized isolation and characterization methods, and an incomplete understandin...
Dual-enhanced transdermal delivery: Magnolol-borneol nanoparticle hydrogel for topical treatment of diabetic peripheral neuropathy [0.03%]
双增强透皮递送：Magnolol-Borneol纳米粒水凝胶外用治疗糖尿病外周神经病变
Zhengzhou Sha,Mingqian Hao,Xi Xue et al.
Zhengzhou Sha et al.
Diabetic peripheral neuropathy (DPN) remains a prevalent and challenging complication of diabetes with limited therapeutic options. Magnolol (Mag), a natural multi-target agent, demonstrates significant potential in managing DPN through syn...
DLP 3D-printed biomimetic periodontium composite with xenogenic treated dentin matrix modulates periodontal regeneration and inflammatory response [0.03%]
仿生牙周组织复合材料调控牙周再生和炎症反应
Xiaoyu Hu,Tao Qiu,Yuxuan Xiao et al.
Xiaoyu Hu et al.
Xenogeneic treated dentin matrix (xTDM) roots serve as a promising donor source for tooth replantation. Nevertheless, the regeneration of the alveolar bone-periodontal ligament (PDL)-cementum complex persists as a challenging task owing to ...
Injectable silk fibroin hydrogel encapsulating pH-Responsive ZnS nanoparticles for synergistic redox modulation and diabetic wound healing [0.03%]
用于协同氧化还原调节和糖尿病伤口愈合的可注射蚕丝蛋白水凝胶负载pH响应型ZnS纳米颗粒
Xi Cheng,Yuchong Wang,Jiao Qian et al.
Xi Cheng et al.
Chronic diabetic wounds remain a major clinical challenge due to excessive reactive oxygen species (ROS), persistent inflammation, and impaired cellular function. Current wound dressings offer limited capacity to simultaneously regulate red...
3D-bioprinted dual-crosslinked oxidized gellan gum-decellularized human amniotic membrane hydrogels reinforced with aminolyzed electrospun nanofibers for cartilage regeneration [0.03%]
用于软骨再生的3D生物打印双重交联的氧化海松胶-脱细胞人胎盘膜水凝胶，增强型胺电纺纳米纤维
Fariba Hashemi-Afzal,Fatemeh Bagheri,Ebrahim Vasheghani-Farahani et al.
Fariba Hashemi-Afzal et al.
Articular cartilage has limited self-healing capacity, driving the need for biomaterial scaffolds that replicate its hierarchical architecture and mechanical resilience. In this study, we present a dual-crosslinked hydrogel system for 3D bi...
Targeted nanotheranostics mitigates radiation-induced fibrosis to promote immune infiltration and enhance radio-chemotherapy in pancreatic ductal adenocarcinoma [0.03%]
靶向纳米治疗诊断技术可缓解放疗诱导的胰腺导管腺癌纤维化以促进免疫浸润并增强放化疗效果
Arjun Sabu,Ying-Chieh Yang,Ritwick Ranjan Sarma et al.
Arjun Sabu et al.
Radiotherapy and chemotherapy exhibit limited clinical efficacy in pancreatic ductal adenocarcinoma (PDAC) due to its dense stromal desmoplasia, acting as a physical barrier that hinders drug penetration and immune cell infiltration while a...
Transcriptomic profiling of osteoblasts on hydroxyapatite-coated-metal-surface reveals enhanced osteogenic and angiogenic processes relevant to accelerated bone healing [0.03%]
羟基磷灰石涂层金属表面成骨细胞转录组分析表明与加速骨骼愈合相关的增强成骨和血管生成过程
Yuki Ogawa,Kosuke Arita,Takayuki Nonoyama et al.
Yuki Ogawa et al.
Hydroxyapatite (HA) coating on orthopedic implants is known to promote osteogenesis and improve bone-implant integration, yet its molecular basis remains to be investigated. Here, transcriptomic profiling of osteoblasts on nano-HA (nHA)-coa...
Wenge Lv,Liangcheng Gu,Xingyu Lin et al.
Wenge Lv et al.
Conventional drug therapies face significant limitations in complex physiological environments, including poor targeting efficiency, passive diffusion mechanisms, and systemic toxicity. Inspired by the immune system, where immune cells are ...
Heterojunction-engineered CNT-MOF hybrid platform for synergistic amplified therapy of bacterial-infected wounds [0.03%]
异质结工程CNT- MOF杂化平台协同放大疗法细菌感染伤口治疗
Yinuo Li,Peng Sun,Wenyi Xu et al.
Yinuo Li et al.
Bacterial wound infections pose a serious clinical threat, often leading to impaired healing and severe complications. To address this challenge, we developed CNT@Por-Cu-MOF, a heterojunction material constructed via in situ growth of Cu(I)...