A novel antimicrobial peptide AH-12 attenuates mitochondrial response to inflammatory stimuli and prevents periodontitis via antibacterial and anti-inflammatory effects [0.03%]
一种新型抗菌肽AH-12通过抗菌和抗炎作用缓解线粒体炎症反应并预防牙周病
Yuanchen Wang,Shuting Zhang,Jinrong Sun et al.
Yuanchen Wang et al.
Antibiotic-assisted periodontal therapy remains a primary clinical strategy, yet the rising prevalence of bacterial resistance severely compromises its therapeutic efficacy. To address this challenge, antimicrobial peptides (AMPs) have emer...
Polymer microspheres in endovascular therapy: From fundamental research to clinical application [0.03%]
聚合物微球在血管内治疗中的应用：从基础研究到临床实践
Andrey N Kuskov,Pavel P Kulikov,Pavel A Yudaev et al.
Andrey N Kuskov et al.
This review highlights the current state of research in the field of the use of microspheres based on natural and synthetic polymers for embolization of hepatocellular carcinoma vessels, embolization of arteries in patients with paraganglio...
Device surface-functionalized ac-SDKP nanoassemblies accelerate endothelial recovery through dual anti-inflammatory and endothelial homeostatic mechanisms [0.03%]
设备表面功能化的ac-SDKP纳米组装体通过双重抗炎和内皮稳态机制加速内皮愈合
Li Li,Huanran Wang,Lai Wei et al.
Li Li et al.
While stents are cornerstone treatments for atherosclerosis, in-stent restenosis remains a challenge. Engineering stent surfaces with specific biochemical signals can prevent this by promoting the crucial and timely regeneration of the endo...
An antagomiR-loaded β-peptide hydrogel promotes functional recovery in mice post-ischaemic stroke [0.03%]
载有抗agomiR的β肽水凝胶促进缺血性卒鼠功能恢复
Yi-Kai Chen,Ketav Kulkarni,Marie-Isabel Aguilar et al.
Yi-Kai Chen et al.
Ischaemic stroke is a leading cause of mortality and disability, arising from interrupted cerebral blood flow and subsequent neuronal death. MicroRNAs, particularly miR-181a, have emerged as promising therapeutic targets due to their roles ...
Superparamagnetic Fe3O4 nanoclusters for cancer therapy and metastasis prevention via synergistic chemotherapy and NETs degradation [0.03%]
一种用于癌症治疗和预防转移的磁性四氧化三铁纳米团簇合成及其协同化疗和NETs降解研究
Liqin Xie,Tianyi Zeng,Dan Li et al.
Liqin Xie et al.
The overexpression of neutrophil extracellular traps (NETs) serves as a critical biomarker and mediator of tumorigenesis and metastasis. By inhibiting their formation or degrading existing structures, therapeutic strategies targeting NETs h...
Synergistic modulation of inflammation and angiogenesis by a polyphenol-functionalized MOF nanozyme for enhancing wound closure [0.03%]
一种聚苯乙烯功能化的MOFs纳米酶协同调节炎症和血管生成以促进伤口闭合
Beibei Han,Yidan Xia,Kai Liu et al.
Beibei Han et al.
Persistent inflammation, excessive oxidative stress, and impaired angiogenesis are persistent challenges that adversely affect skin wound healing, which are particularly prominent in diabetic wounds and often lead to hindered repair process...
Prevention of brain scarring during cranial reconstruction through a bioactive polymer coating [0.03%]
用于颅骨重建的生物活性聚合物涂层可防止脑部疤痕形成
Sara Shakibania,Daria Niewolik,Taral Patel et al.
Sara Shakibania et al.
Although cranioplasty is a long-established surgical procedure used to repair or reshape skull defects, it is not devoid of side effects arising from the formation of a scar tissue between dura, implant, and subcutaneous tissue. To minimize...
Amine functionalized TiO2 doped mesoporous bioactive glass coated curcumin infused 3d printed poly (L-lactic acid): A promising multifunctional scaffold with enhanced osteogenesis and tumour relapse inhibition characteristics [0.03%]
胺功能化的TiO2掺杂介孔生物活性玻璃包覆的姜黄素浸渍的3D打印聚(L-乳酸)：一种具有增强成骨和抗肿瘤复发特性的多功能支架
Shubham Pant,Sravanthi Loganathan,Ravi Babu Valapa
Shubham Pant
The two main clinical problems with post-operative metastatic bone disease are high death rate and a notable local recurrence rate. When diseased bone sections are removed from patients, they suffer from significant bone defects that cannot...
An injectable dual-drug-loaded hydrogel for the treatment of bacterial endophthalmitis [0.03%]
一种用于治疗细菌性眼内炎的可注射双药载水凝胶
Jianzhong He,Huixiang Ma,Yan Zhang et al.
Jianzhong He et al.
Bacterial endophthalmitis is a severe ocular infection that frequently leads to severe visual impairment or blindness. Current clinical treatments primarily rely on intravitreal antibiotics to eliminate pathogens; however, these often fail ...
Cerium-based nanoplatforms inhibiting goblet cell-associated antigen passages to stabilize barrier function in ulcerative colitis [0.03%]
铈基纳米平台通过抑制杯状细胞相关抗原传递来稳定溃疡性结肠炎的屏障功能
Mao Tang,Laixian Zhou,Haitao Ran
Mao Tang
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon characterized by recurrent mucosal inflammation and ulceration. Since managing UC remains challenging due to frequent therapeutic resistance and relapse, there is a pres...