A novel ROS switcher potentiates the type-I photodynamic effect of sodium zinc chlorophyllin against Pseudomonas aeruginosa in diabetic wounds [0.03%]
一种新型ROS转换开关增强藻蓝素介导的糖尿病伤口铜绿假单胞菌PDIA型光动力效应
Guodong Wang,Hongjie Chen,Lusheng Wu et al.
Guodong Wang et al.
Skin wound infections present a serious threat to human health, with bacterial infections in diabetic wounds being particularly challenging due to impaired healing. Gram-negative bacteria are common pathogens in diabetic wound infections an...
Multifunctional conductive hydrogel integrating exosome delivery and electrical stimulation for enhanced diabetic wound healing [0.03%]
一种集外泌体递送和电刺激于一体的多功能导电水凝胶促进糖尿病伤口愈合
Weibin Wang,Yufeng Huang,Xuehui Chen et al.
Weibin Wang et al.
Diabetic wound healing is severely hampered by persistent inflammation, vascular dysfunction, infection risk, and oxidative stress. To overcome these challenges, we developed a multifunctional conductive hydrogel platform (Gel@Exo-ES). This...
A novel polymeric hydrogel of Periplaneta americana polysaccharide loaded with kaempferol-chitosan microspheres, which possesses antibacterial, hemostatic, antioxidant and wound healing promoting activities [0.03%]
一种新型美洲蠊多糖水凝胶，载壳聚糖癸酰基元胶囊微球，兼具抗菌、止血、抗氧化及促创面愈合作用
Yiting Yang,Hanwen Hu,Xinxin Zhang et al.
Yiting Yang et al.
Periplaneta americana, as a traditional Chinese medicine, is widely used in wound repair. We isolated and purified a heteropolysaccharide PAP55-1-2 (8.13 kDa) from Periplaneta americana medicinal materials, which is mainly composed of N-ace...
Multilayered electrospun membranes incorporating microspheres embedded nanofibers for enhanced wound healing [0.03%]
负载微球的纳米纤维膜促进伤口愈合性能研究
Fen Ao,Wen Shen,Xuemei Ge et al.
Fen Ao et al.
Multilayer membranes that coordinate the release of different drugs to match the various stages of wound healing while managing excessive tissue exudate represent a promising therapeutic approach. However, achieving precise control over the...
Piezoelectric nanocomposite patch for self-powered bioelectrical stimulation for cardiac tissue engineering [0.03%]
用于心脏组织工程的压电纳米复合贴片自供电生物电刺激
Hyunjin Kim,Kannan Badri Narayanan,Vineet Kumar et al.
Hyunjin Kim et al.
Cardiovascular diseases remain the leading cause of mortality worldwide, and myocardial infarction results in irreversible loss of functional myocardium with limited regenerative treatment options. Here, we report a self-responsive piezoele...
Mesoporous polydopamine loaded with silver nanoparticles and quercetin for bacterial keratitis treatment through antibacterial and anti-angiogenic mechanisms [0.03%]
基于抗菌和抗血管生成机制的介孔聚多巴胺/银纳米粒子/芦丁复合材料治疗细菌性角膜炎研究
Meiliang Wu,Rong Liu,Weijin Nan et al.
Meiliang Wu et al.
Bacterial keratitis (BK) is a serious blinding eye disease, with pathological features mainly including corneal stromal opacity, edema, inflammatory response, and corneal neovascularization (CoNV). Timely intervention and treatment are requ...
Trifunctional nanoparticles accelerate diabetic wounds healing via oxidative-immune-vascular coordination [0.03%]
三功能纳米颗粒通过氧化-免疫-血管协同作用加速糖尿病伤口愈合
Yanming Zuo,Qin Cao,Zhihao Jin et al.
Yanming Zuo et al.
Current treatments for diabetic wounds remain a critical clinical challenge due to their suboptimal therapeutic efficacy. Patients with diabetic wounds suffer from prolonged inflammation, ROS overproduction, and impaired angiogenesis, creat...
3D-printed carbonate apatite scaffolds inspired by cuttlebone biomechanics and blood flow dynamics for layer-by-layer collapse and spatial bone formation [0.03%]
受鹦鹉螺骨生物力学和血流动力学启发的分层塌陷和空间骨形成的3D打印碳酸盐羟基磷灰石支架
Ahmad Nazir Taleb Alashkar,Koichiro Hayashi,Kunio Ishikawa
Ahmad Nazir Taleb Alashkar
In bone tissue engineering, scaffolds are required to resist mechanical impact and promote bone regeneration, both are highly dependent on the structure of the scaffolds. In this study, we aimed to develop scaffolds inspired by the uniquely...
Recent advances in engineering approaches for delivery of mRNA-based therapeutics [0.03%]
用于基于mRNA治疗的工程化给药方式的新进展
Ken Ninez Nurpramesti Prinindya,Ghulam Md Ashraf,Shihab Uddin et al.
Ken Ninez Nurpramesti Prinindya et al.
Nucleic acid-based treatments, particularly those based on messenger RNA (mRNA) interventions, have recently revolutionized the biomedical fields through breakthroughs in both their formulations and delivery systems. Successful use of mRNA ...
Polymeric micelles for encapsulation of plant-derived bioactives: a decade of advances in antimicrobial, antitumor, and antioxidant applications [0.03%]
基于植物源生物活性成分的聚合物胶束载药体系的研究进展：抗菌、抗肿瘤及抗氧化领域十年回顾
Astrid Corrales,James Villar,Ana Lívia de Carvalho Bovolato et al.
Astrid Corrales et al.
This 10-year review provides a comprehensive overview of advances in the use of polymeric micelles (PMs) for the encapsulation of bioactive compounds derived from renewable green sources. PMs have emerged as highly versatile nanocarriers th...