Development of 2-deoxy-d-ribose and zinc oxide loaded microneedle array patches of chitosan and PVA to stimulate angiogenesis and reduce infection and promote wound healing [0.03%]
基于壳聚糖和PVA的2-脱氧-D-核糖及氧化锌载药微针阵列贴片的制备及其促伤口愈合作用研究
Kanzal Abbas,Aimen Masaud Khan,Muhammad Shahbaz Nawaz et al.
Kanzal Abbas et al.
This study reports the development of dual-functional, dissolvable microneedle array patches (MN) integrating chitosan, polyvinyl alcohol (PVA), tetraethyl orthosilicate (TEOS), 2-deoxy-d-ribose (2dDR), and zinc oxide (ZnO) for chronic woun...
Biocompatibility and degradation of PLA reinforced with tungsten disulfide nanotubes for 3D-printed bone scaffold [0.03%]
用于3D打印骨支架的二硫化钨纳米管增强PLA的生物相容性和降解性
Ofek Golan,Noa Granada,Lin Lemesh et al.
Ofek Golan et al.
Advancements in bone tissue engineering have increased interest in 3D-printed scaffolds for bone regeneration. Polylactic acid (PLA), a biocompatible and biodegradable polyester, is a promising candidate for bone scaffold materials. Reinfor...
Solanum lyratum-derived metal-free bio-nanozyme for photothermally self-enhanced cascade catalytic synergistic tumor therapy [0.03%]
基于金属离子的天然有机纳米酶用于光热协同增强级联催化协同肿瘤治疗
Xiaole Yin,Baowen Dong,Yimei Zhang et al.
Xiaole Yin et al.
Developing multifunctional nanoplatforms for synergistic tumor therapy remains a significant challenge. Here, we report a metal-free bio-nanozyme (SL-BN) derived from the natural medicinal plant Solanum lyratum (SL) via a facile two-step so...
Technical discussion on the methodological and interpretative aspects of "mineralized extracellular matrix composite scaffold incorporated with salvianolic acid a enhances bone marrow mesenchymal stem cell osteogenesis and promotes calvarial bone regeneration" [0.03%]
有关“载羟基喜树碱的矿化细胞外基质复合支架增强骨髓间充质干细胞成骨分化和促进颅盖骨缺损再生修复的研究”方法学及结果解读的技术讨论
Luis F O Silva
Luis F O Silva
A self-setting magnesium phosphate bone putty for effective hemostasis and osteogenesis in bleeding bone defect [0.03%]
一种自硬性镁磷灰石骨糊，用于出血骨缺损的有效止血和成骨作用
Yinan Wang,Ziyang Liu,Xiaoxuan Wu et al.
Yinan Wang et al.
Intraoperative bleeding associated with bone defects often impairs surgical outcomes. Traditional hemostatic bone wax acts as a passive, non-degradable barrier, whose biological inertness typically triggers inflammation and hinders bone reg...
Coaxial bioprinting of microsphere bioink to engineer heterogeneous vascularized lung cancer model [0.03%]
用于工程异质性血管化肺癌模型的微球生物墨水同轴生物打印技术
Qiulei Gao,Zhongwei Guo,Shiqiang Zhang et al.
Qiulei Gao et al.
3D bioprinting is a promising strategy for engineering in vitro tumor models. However, replicating the intratumoral parenchyma-stroma heterogeneity remains challenging due to the poor formability of biomimetic bioinks. In this study, we dev...
Dual-functional β-TCP based injectable bone grafts functionalized with peptides for enhanced osteogenesis and broad-spectrum biofilm inhibition [0.03%]
一种双重功能的β-TCP基注射骨移植材料，其功能化的肽可促进成骨并广泛抑制生物膜形成
Eda Bilgiç,Şevval Özkaya,Duygu Gençer et al.
Eda Bilgiç et al.
Bone defects with irregular geometries and high infection risk remain a major clinical challenge. Injectable bone grafts (IBGs) offer minimally invasive and moldable solutions, yet conventional β-tricalcium phosphate (β-TCP)-based formula...
Poly-5-aminoindole:Poly(4-styrenesulfonic acid) loaded locust bean gum/xanthan gum hydrogel for transdermal delivery of Imatinib via iontophoresis [0.03%]
用于离子导入递送伊马替尼的瓜胶/黄原胶载聚-5-氨基吲哚:聚(4-苯乙烯磺酸盐)水凝胶
Patamavadee Tapsarn,Phimchanok Sakunpongpitiporn,Nophawan Paradee et al.
Patamavadee Tapsarn et al.
Melanoma is an aggressive type of skin cancer due to its ability to rapidly spread to various organs. The oral drug administration is preferred for its convenience. However, the oral route faces challenges, including the first-pass metaboli...
Plant-derived extracellular vesicles as a dual-function nanoplatform for synergistic neurovascular repair in ischemic stroke [0.03%]
基于植物的外泌体作为治疗缺血性卒中的多功能纳米平台以协同修复神经血管损伤
Cong Wang,Ke Che,Qi Zheng et al.
Cong Wang et al.
Current therapies for ischemic stroke lack the capacity to simultaneously restore metabolic homeostasis, repair the neurovascular unit, and deliver hydrophobic neuroprotectants across the blood-brain barrier. Here, we demonstrate that extra...
In-situ engineering of a covalent organic framework-based biomimetic nanoplatform for multi-target therapy of Alzheimer's disease [0.03%]
基于共价有机框架的仿生纳米平台的原位工程化用于阿尔茨海默病的多靶标治疗
Yujiao Yan,Yutong Chen,Fengmei Yang et al.
Yujiao Yan et al.
To address the complex pathology of Alzheimer's disease (AD), including abnormal amyloid-β (Aβ) aggregation, metal ion homeostasis disruption and oxidative stress, we developed an integrated multifunctional nanoplatform. This platform lev...