Alteration in gene expression patterns and increased drug resistance in MCF7 breast cancer cells cultured on 3D collagen-based scaffolds [0.03%]
基于三维胶原蛋白的支架培养的MCF7乳腺癌细胞中的基因表达模式改变及耐药性增加现象研究
John Redmond,Srishti Agarwal,Helen O McCarthy et al.
John Redmond et al.
2D models have been instrumental in breast cancer research and advancing our knowledge of the disease, both in terms of progression and treatment. However, they fail to replicate the three-dimensional (3D) architectural and microenvironment...
ZnO/curcumin nanobio-complex loaded bioactive multifunctional gelatin-PCL membranes for accelerated wound healing through enhanced angiogenesis [0.03%]
一种负载多功能明胶-PCL膜的ZnO/姜黄素纳米生物复合材料通过促进血管生成加速伤口愈合
Md Yousuf Ali,Prayas Chakma Shanto,Myeongki Park et al.
Md Yousuf Ali et al.
Activation of early angiogenesis, establishment of antimicrobial protection, and maintenance of an optimal moist microenvironment are the crucial factors for accelerated and scar-free wound healing. To achieve this, we synthesized ZnO/curcu...
Spatiotemporally controlled pretargeted azide-functionalized M1 macrophage-derived exosome-based 68Ga/177Lu theranostic system for PET imaging and targeted radiotherapy in breast cancer [0.03%]
基于PET成像和靶向放射治疗的时空控制预目标氨基功能化的M1巨噬细胞源性外泌体的68Ga/177Lu诊疗系统用于乳腺癌的研究
Wen Zheng,Yang Wang,Xinyu Wang et al.
Wen Zheng et al.
Spatiotemporal control of injectable biomaterials is emerging as a powerful strategy to enhance precision theranostics. We report here an injectable, two-step pretargeting system that leverages M1 macrophage-derived exosomes metabolically e...
Composite nanozymes surface-coated with thioketal and di-sulfide-containing polyurethane for acute lung injury treatment [0.03%]
用于急性肺损伤治疗的复合纳米酶并包覆有硫酮和二硫键含聚氨酯涂层
Beiduo Wang,Wei Ouyang,Cheng Zhang et al.
Beiduo Wang et al.
Acute lung injury (ALI) is a prevalent and life-threatening condition lacking specific and effective treatments. To mitigate the inflammatory response within the ALI microenvironment, in this study a novel polyurethane (PCLSTU) was synthesi...
Laminin 1 enhances the angiogenic and neurogenic potential of collagen-based scaffolds for complex wound healing applications [0.03%]
层粘连蛋白1增强胶原基质材料的促血管生成和神经营养潜能促进复杂伤口的修复与再生
M McGrath,J C Palomeque-Chávez,C O&#x;Connor et al.
M McGrath et al.
Chronic wounds fail to progress through the normal stages of healing, with insufficient vascularisation and dysfunctional neural regrowth playing a key role in their inability to heal. Collagen-glycosaminoglycan scaffolds have shown promise...
Neutrophil-mimetic M2 macrophage extracellular vesicle for targeted spinal cord injury therapy [0.03%]
模拟中性粒细胞的M2型小胶质细胞外泌体实现脊髓损伤修复治疗
Yinghui Shang,Wei Wang,Tehan Zhang et al.
Yinghui Shang et al.
Spinal cord injury (SCI) results in severe neurological dysfunction primarily due to secondary inflammation and neuronal apoptosis. Developing effective therapies with both targeting capability and neuroprotective effects remains a signific...
Demystifying targeting potential of surface-functionalized liposome for BTK inhibitor delivery in breast cancer therapy: Multiphase validation from in-silico to in-vivo [0.03%]
揭秘表面功能化脂质体靶向潜力，用于乳腺癌治疗中BTK抑制剂递送：从计算机模拟到体内实验的多阶段验证
Indrani Maji,Ezhilmathe Athavan,Sharon Munagalasetty et al.
Indrani Maji et al.
Surface-functionalized nanocarriers have transformed cancer therapy by enabling targeted delivery of anti-cancer agents. In the present work, Tocophersolan (TPGS), a water-soluble form of natural Vitamin E, was evaluated as a targeting liga...
Biomimetic 3D-printed bilayered scaffold with stem cell delivery for rabbit vaginal regeneration [0.03%]
用于兔阴道再生的仿生分层3D打印干细胞递送支架
Xuemei Zhang,Jiahua Zheng,Xiaotong Xu et al.
Xuemei Zhang et al.
Traditional biological scaffolds for vaginal reconstruction often fail to restore the physiological bilayered structure of vaginal tissue, leading to post-operative complications such as contraction, stenosis, and fibrosis. To address this,...
Thermosensitive porcine acellular dermal matrix hydrogel loaded with umbilical cord mesenchymal stem cell-derived exosomes for diabetic wound healing repair [0.03%]
负载脐带间充质干细胞外泌体的温敏猪脱细胞真皮基质水凝胶用于糖尿病创面修复
Xunrui Zhang,Yuhui Cai,Lele Wang et al.
Xunrui Zhang et al.
Patients with type II diabetes mellitus (DM) often experience severely impaired skin wound healing due to hyperglycemia-induced microvascular dysfunction, peripheral neuropathy, and persistent inflammation, creating an urgent need for new t...
Corrigendum to "Response of human periosteal cells to degradation products of zinc and its alloy" [Mater. Sci. Eng. C 108 (2020) 110208] [0.03%]
“人骨外膜细胞对锌及其合金降解产物的响应”一文的手稿修正案[Mater. Sci.Eng. C 108(2020)110208]
Ping Li,Jingtao Dai,Ernst Schweizer et al.
Ping Li et al.
Published Erratum
Biomaterials advances. 2025 Nov 30:214628. DOI:10.1016/j.bioadv.2025.214628 2025