Exploiting mechanistic insights to improve the delivery of nanomaterials and extracellular vesicles to tumors [0.03%]
利用机制见解改善纳米材料和细胞外囊泡向肿瘤递送
Daniela León García,Karen Bolaños,Pamela Contreras et al.
Daniela León García et al.
The main current challenges in oncology therapy are (1) improving the targeting of chemotherapeutics to tumors and (2) developing alternative treatments for metastatic tumors. Nanomedicine can provide an answer to these problems; however, t...
Biphasic bone-mimicking constructs containing silk fibroin peptide enhanced bone regeneration in segmental defects in rats [0.03%]
仿生双相载丝素肽复合物促进大段骨缺损修复中的骨再生作用研究
Amin Ebrahimi Sadrabadi,Seyed Shahriar Arab,Amir Kamali et al.
Amin Ebrahimi Sadrabadi et al.
To advance bone tissue engineering, it is essential to design and integrate biomaterials that can closely mimic the microarchitecture of native tissue and enhance biological functionality. This study presents a biphasic bone-mimicking const...
The extracellular matrix HA promotes the YAP/hypoxia axis of glioblastoma cells on 3D agar/HA scaffolds [0.03%]
透明质酸促进胶质母细胞瘤细胞在3D琼脂/HA支架上的YAP/缺氧轴作用
Nicole Fratini,Carolina Castillo,Roberta Grillo et al.
Nicole Fratini et al.
The tumour microenvironment of glioblastoma (GBM) as defined by mechanical heterogeneity, hypoxia, and hyaluronic acid (HA)-rich extracellular matrix (ECM), is a highly dynamic milieu which influences tumour progression and therapeutic resi...
Supercritical CO2-foamed hierarchically porous PLA/PBS-based scaffold for advanced bone regeneration [0.03%]
一种用于骨再生的超临界CO₂发泡PLA/PBS基分级多孔支架
Shan Tang,Guobin Huang,Chengyong Li et al.
Shan Tang et al.
This study presents a novel porous bone scaffold system (PBCMH) fabricated by melt blending and supercritical CO2 (scCO2) foaming, incorporating nano-hydroxyapatite (nHA), chitosan, polylactic acid (PLA), and polybutylene succinate (PBS). F...
Nanomaterial-based strategies to modulate macrophage polarization in osteoarthritis: A systematic review [0.03%]
基于纳米材料调制骨关节炎巨噬细胞极化的策略：系统性综述
Giorgia Codispoti,Luca Cavazza,Melania Carniato et al.
Giorgia Codispoti et al.
Osteoarthritis (OA) is a chronic degenerative joint disease characterised by progressive functional impairment due to erosion of the articular cartilage, remodelling of the subchondral bone and inflammation of the synovial tissue. In additi...
Fabrication, characterization, and in vivo biosafety evaluation of starch-based bioplastic as a sustainable alternative to polystyrene [0.03%]
一种基于淀粉的生物塑料的制备、表征及体内生物安全性评价：作为一种可持续的聚苯乙烯替代品
Muhammad Usman Zahid,Hashaam Akhlaq,Khazeena Atta et al.
Muhammad Usman Zahid et al.
The widespread use of synthetic plastics such as polystyrene raises concerns over long-term environmental persistence and biological toxicity. Although bioplastics offer a promising alternative, their in vivo biosafety and comparative evalu...
Mesenchymal stem cell-derived small extracellular vesicles loaded with miRNA-4488 alleviate chemotherapy-induced premature ovarian insufficiency via mitigation of apoptosis and oxidative stress [0.03%]
间充质干细胞源性装载miR-4488的小细胞外囊泡通过抑制凋亡和氧化应激治疗化疗诱导的卵巢早衰
Shi-Xian Li,Shi-Yao Wei,Chai Li et al.
Shi-Xian Li et al.
Chemotherapy-induced premature ovarian insufficiency (POI) can disrupt endocrine homeostasis in female cancer patients. Since current therapeutic options remain inadequate, there is an urgent need to develop new strategies for POI preventio...
Self-healing hydrogels incorporating hyaluronic acid, poly(Acrylic Acid), and ferric ions for flexible sensing and wound healing [0.03%]
一种含有透明质酸、聚丙烯酸和铁离子的自修复水凝胶用于柔性传感和伤口愈合
Mosayeb Gharakhloo,Samaneh Khodami,Asghar Eskandarinia et al.
Mosayeb Gharakhloo et al.
In this study, novel hydrogels based on polyacrylic acid, hyaluronic acid, and ferric ions as non-covalent crosslinkers were synthesized via a one-pot method. The influence of hyaluronic acid on the mechanical and functional properties of t...
Semi-degradable biomimetic double-layer small diameter vascular graft for arteriovenous fistula in large animals [0.03%]
大动物动静脉内瘘用半可降解双层结构仿生小直径血管移植物的研究
Zhiping Fang,Yonghao Xiao,Jubo Li et al.
Zhiping Fang et al.
A double layer small diameter vascular graft (SDVG) was fabricated by sequential electrospinning. The inner layer was composed by three kinds of biodegradable poly (ε-caprolactone) (PCL) fibers with three different molecular weights to ind...
Sustainable silk fibroin scaffolds for bone repair: assessing their osteogenic potential via AI-enhanced synchrotron imaging workflow [0.03%]
基于人工智能的同步加速器成像工作流程评估可持续丝素支架骨再生潜力及其成骨作用
G Dei Rossi,F Buccino,E Longo et al.
G Dei Rossi et al.
Effective bone regeneration requires scaffolds capable of guiding and supporting new mineralized matrix formation. In this study, silk fibroin constructs cultured with human mesenchymal stem cells (hBMSCs) in the presence of either Fetal Bo...