A biointerface-engineered gold nanocluster platform for icariin delivery: Dual-pathway modulation of osteoblast and osteoclast dynamics in osteoporosis therapy [0.03%]
用于治疗骨质疏松的淫羊藿次苷I输送的生物界面工程金纳米团簇平台：调节成骨细胞和破骨细胞双通道方法
Changxu Wang,Shenghao Shi,Fei Wang et al.
Changxu Wang et al.
Osteoporosis is a prevalent metabolic bone disorder characterized by an imbalance between bone resorption and formation. Current therapeutic options are constrained by side effects and low bioavailability. Icariin (ICA), a naturally derived...
Twin-induced strengthening biodegradable ZnMg alloys for the orthopedic implants [0.03%]
用于骨科植入物的孪晶强化可降解ZnMg合金
Li He,Jiawei Cai,Yifan Wang et al.
Li He et al.
Biodegradable zinc (Zn) has limitations in the orthopedic conditions due to its low mechanical strength. Alloying with magnesium (Mg) and thermomechanical process are effective ways to overcome the limitations. This work demonstrates that t...
Tunable gelatin-based semi-IPN adhesive hydrogel for enhanced self-healing and hemostatic performance [0.03%]
一种可调的明胶半-IPN粘合水凝胶以增强自愈和止血性能
Ghazal Yaghoubi,Mahshid Kharaziha,Mehran Nahvi
Ghazal Yaghoubi
Herein, we report semi-interpenetrating polymer network (semi-IPN) hydrogels composed of gelatin conjugated with oxidized caffeic acid and L-arginine (L-Arg), and various concentrations of acrylamide (6, 12, and 24 wt%). The resulting semi-...
Gelatin/starch hydrogel tissue adhesive loaded with EGCG-Zr complex with antibacterial, antioxidant, and immunomodulatory properties for advanced wound healing [0.03%]
一种具有抗菌、抗氧化和免疫调节性能的EGCG-Zr复合物负载明胶/淀粉水凝胶组织粘合剂促进创面修复
Yahui Xie,Yun Liu,Haibo Zhao et al.
Yahui Xie et al.
Surgical suture techniques are commonly used for hemostasis and wound closure, but they often fail to achieve optimal results, particularly in post-laceration hemostasis and healing. Furthermore, complications such as bacterial infections, ...
Immunomodulatory and pro-mineralizing effects of an injectable baicalein-loaded methacrylated gelatin hydrogel for vital pulp therapy [0.03%]
一种载有黄芩素的甲基丙烯酸明胶水凝胶的免疫调节和促矿化作用用于活髓保存治疗
Beatriz Ometto Sahadi,Igor Paulino Mendes Soares,Chloe Gifford et al.
Beatriz Ometto Sahadi et al.
This study first investigated the biological function of baicalein (BA) and then developed a photocrosslinkable methacrylated gelatin (GelMA) hydrogel incorporating BA-loaded, carboxylated mesoporous silica nanospheres (MSNs-COOH-BA) for vi...
A neutrophil membrane-biomimetic drug delivery system enhances the antifungal and anti-inflammatory efficacy of natamycin for fungal keratitis [0.03%]
仿中性粒细胞膜的递药系统可增强那他霉素治疗真菌性角膜炎的抗真菌和抗炎效应
Zhenglu Tong,Huijin Duan,Lina Zhang et al.
Zhenglu Tong et al.
Fungal keratitis (FK) is a potentially blinding infectious corneal disease. The invasion of fungi into corneal tissue and the resulting inflammatory response primarily drive the rapid corneal damage. Although natamycin (NAT) is the first-li...
Acoustic hydrogen delivery to treat PANoptosis induced by myocardial ischemia/reperfusion injury in rats [0.03%]
声学氢气输送治疗心肌缺血再灌注损伤引起的PAN凋亡
Shu-Hui Wang,Chen-Hui Li,Zi-Jun Wei et al.
Shu-Hui Wang et al.
Myocardial ischemia/reperfusion (MIR) injury remains a major clinical challenge with limited therapeutic options. Although molecular hydrogen (H₂) possesses therapeutic potential, its clinical translation is hindered by poor solubility and...
Advances in β-titanium alloys for safer and greener biomedical implants [0.03%]
用于更安全和更绿色的生物医学植入物的β型钛合金研究进展
Dulexy Solano-Orrala,Eliana Díaz-Cruces,Jorge Troconis et al.
Dulexy Solano-Orrala et al.
In the biomedical field, titanium alloys have long been preferred for orthopedic and dental devices due to their excellent biocompatibility and mechanical strength, making them suitable for long-term implantation. However, recent findings i...
Ultrasound-mediated blood-brain barrier opening for targeted neurological drug delivery [0.03%]
声波介导的血脑屏障开启用于靶向神经药物递送
Zibo Qin,Zhangbaihe Wang,Cancan Gao et al.
Zibo Qin et al.
Neurological disorders represent a devastating global health crisis, and the blood-brain barrier (BBB) remains a major obstacle for their treatment. Conventional strategies for BBB opening, including direct intracranial injection, osmotic d...
In situ photocrosslinking ROS-adaptive caffeoyl chitosan/boronic acid-grafted gelatin hydrogels for treatment of combined radiation-burn injury [0.03%]
用于联合放射烧伤治疗的原位光交联ROS自适应咖啡酰壳聚糖/硼酸接枝明胶水凝胶
Dongyang Fang,Shufeng Chen,Cuixue Wu et al.
Dongyang Fang et al.
Combined radiation-burn injury (CRBI) is a serious wound that is difficult to treat and typically results from radiation therapy, nuclear explosions, or nuclear accidents, where ionizing radiation and thermal burns usually occur simultaneou...