Rethinking blood eosinophil counts: Epidemiology, associated chronic diseases, and increased risks of cardiovascular disease [0.03%]
重新思考血液嗜酸性粒细胞计数：流行病学、相关慢性疾病以及心血管疾病的增加风险
Thanai Pongdee,Sheila M Manemann,Paul A Decker et al.
Thanai Pongdee et al.
Background: The distribution and determinants of blood eosinophil counts in the general population are unclear. Furthermore, whether elevated blood eosinophil counts increase risk for cardiovascular disease (CVD) and othe...
Ketone body augmentation decreases methacholine hyperresponsiveness in mouse models of allergic asthma [0.03%]
酮体增强可降低过敏性哮喘小鼠模型的甲胆碱高反应性
Madeleine M Mank,Leah F Reed,V Amanda Fastiggi et al.
Madeleine M Mank et al.
Background: Individuals with allergic asthma exhibit lung inflammation and remodeling accompanied by methacholine hyperresponsiveness manifesting in proximal airway narrowing and distal lung tissue collapsibility, and the...
Phenotypic characterization of childhood- and adult-onset food allergy among adults in the United States [0.03%]
美国成人童年期和成人期起病的食物过敏的表型特征分析
Haley Hultquist,Ashley Dyer,Jialing Jiang et al.
Haley Hultquist et al.
Background: Food allergy (FA) affects ~10% of adults; however, little is known about the extent to which FA phenotypes and psychosocial burden vary depending on timing of allergy onset, whether in childhood or as an adult...
Age-dependent rebound in asthma exacerbations after COVID-19 lockdown [0.03%]
COVID-19封城后哮喘加重的年龄依赖性反弹
Guy Hazan,Carolyn Fox,Huram Mok et al.
Guy Hazan et al.
Background: Virus mitigation measures enacted early in the coronavirus infectious disease 2019 (COVID-19) pandemic suppressed common respiratory viruses and reduced the number of obstructive lung disease exacerbations. Ho...
Reduced COVID-19 vaccine response in patient treated with dupilumab for IgG4-related disease [0.03%]
接受Dupixent治疗的IgG4相关性疾病患者的COVID-19疫苗反应减弱
Armin Abadeh,Jason Kihyuk Lee
Armin Abadeh
Dupilumab is a novel anti-IL-4 receptor-α mAb that targets the signaling pathways of IL-4 and IL-13. Thus far, the data about adequate humoral immune response after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-...
Asthma exacerbations during the pandemic: Time to rethink clinical markers [0.03%]
大流行期间的哮喘加重：是时候重新考虑临床标志物了
Hector Ortega,Lynn Eva Katz,Geoffrey Chupp
Hector Ortega
Background: Reductions in asthma exacerbations during the coronavirus disease 2019 (COVID-19) pandemic may have an impact on clinical trial enrollment and outcomes. ...
Haploidentical CD3+ TCR αβ/CD19+-depleted HSCT for MHC class II deficiency and persistent SARS-CoV-2 pneumonitis [0.03%]
人白细胞抗原半相合CD3+TCRαβ/CD19阴性细胞清除造血干细胞移植治疗人类白细胞抗原二期缺陷及持续的SARS-CoV-2肺炎
Subramaniam Ramanathan,Liz Veramendi-Espinoza,Benjamin Shillitoe et al.
Subramaniam Ramanathan et al.
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to coronavirus disease 2019 (COVID-19), which can range from a mild illness to a severe phenotype characterized by acute respiratory...
Time-dependent contraction of the SARS-CoV-2-specific T-cell responses in convalescent individuals [0.03%]
新冠恢复期个体中SARS-CoV-2特异性T细胞反应的时间依赖性收缩现象
Edgar Ruz Fernandes,Juliana de Souza Apostolico,Lucas Cauê Jacintho et al.
Edgar Ruz Fernandes et al.
Background: Adaptive immunity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is decisive for disease control. Delayed activation of T cells is associated with a worse outcome in coronavirus dise...
Second-dose mRNA COVID-19 vaccine safety in patients with immediate reactions after the first dose: A case series [0.03%]
首次接种新冠mRNA疫苗后出现急性不良反应者第二次接种的安全性：系列病例报道
Aled Iaboni,Nina Jindal,Stephen D Betschel et al.
Aled Iaboni et al.
Background: The rates of suspected allergic reactions to the first dose of the coronavirus disease 2019 (COVID-19) mRNA vaccines have been reported to be as high as 2%, with an anaphylaxis incidence up to 2.5 per 10,000 i...
Impact of COVID-19 mitigation strategies on asthma hospitalizations in Brazil [0.03%]
新冠肺炎防控策略对巴西哮喘住院的影响
Frederico Friedrich,Lucas Montiel Petry,Marcos Brum et al.
Frederico Friedrich et al.
Background: In 2020, a unique social experience was provided by the pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2. Interventions to tackle the pandemic may affe...