JAK1 inhibition with abrocitinib decreases allergen-specific basophil and T-cell activation in pediatric peanut allergy [0.03%]
ABROCIDINIB通过抑制JAK1减轻儿童对花生过敏的特异性嗜碱性粒细胞和T细胞活化反应
Nicole Ramsey,Wajiha Kazmi,Matthew Phelan et al.
Nicole Ramsey et al.
Background: JAK1 is a signaling molecule downstream of cytokine receptors, including IL-4 receptor α. Abrocitinib is an oral JAK1 inhibitor; it is a safe and effective US Food and Drug Administration-approved treatment f...
Reduced prevalence of childhood asthma after housing renovations in an underresourced community [0.03%]
一项针对低资源社区的住房改造后哮喘儿童减少的研究
Andrew F Beck,Larry Wymer,Eugene Pinzer et al.
Andrew F Beck et al.
Background: Despite improvements in asthma symptom management and asthma morbidity, the prevalence of asthma in the United States remains high, especially in underresourced communities. ...
Coordinated Health Care Interventions for Childhood Asthma Gaps in Outcomes (CHICAGO) plan [0.03%]
针对儿童哮喘护理干预的协调计划(CHICAGO计划)
Jerry A Krishnan,Helen Margellos-Anast,Rajesh Kumar et al.
Jerry A Krishnan et al.
Background: Evidence-based strategies to improve outcomes in minority children with uncontrolled asthma discharged from the emergency department (ED) are needed. ...
Metabolomics identifies disturbances in arginine, phenylalanine, and glycine metabolism as differentiating features of exacerbating atopic asthma in children [0.03%]
基于儿童哮喘加重的代谢组学研究发现精氨酸、苯丙氨酸和甘氨酸代谢紊乱是哮喘加重的独特标志
Kirsten A Cottrill,Joshua D Chandler,Seibi Kobara et al.
Kirsten A Cottrill et al.
Background: Asthma exacerbations are highly prevalent in children, but only a few studies have examined the biologic mechanisms underlying exacerbations in this population. ...
Granzymes, IL-16, and poly(ADP-ribose) polymerase 1 increase during wildfire smoke exposure [0.03%]
颗粒物污染小鼠模型中粒酶、IL-16 和多(ADP-核糖)多聚化酶 1 的增加及野生火烟暴露对其影响
Juan Aguilera,Abhinav Kaushik,Nicholas Cauwenberghs et al.
Juan Aguilera et al.
Background: Given the increasing prevalence of wildfires worldwide, understanding the effects of wildfire air pollutants on human health-particularly in specific immunologic pathways-is crucial. Exposure to air pollutants...
Danielle R Stevens,Edwina Yeung,Stefanie N Hinkle et al.
Danielle R Stevens et al.
Background: Asthma affects 10% of pregnancies and may influence offspring health, including infant size and body composition, through hypoxic and inflammatory pathways. ...
Identification of a heterozygous pathogenic variant in IRAK4 in an adult patient with pneumococcal sepsis, monoclonal gammopathy of uncertain significance, and idiopathic systemic capillary leak syndrome [0.03%]
成人肺炎链球菌败血症、单克隆免疫球蛋白意义未明血症和特发性全身毛细血管渗漏综合征患者IRAK4基因杂合病理性变异的鉴定
Jessica Galant-Swafford,Kirk M Druey,Divya Verma et al.
Jessica Galant-Swafford et al.
IRAK-4 haploinsufficiency can present with pneumococcal sepsis and poor pneumococcal vaccine response in adults. Further research can determine the significance of unrecognized pathogenic variants in IRAK4 in adults presenting with pneumoco...
Associations between serum per- and polyfluoroalkyl substances and asthma morbidity in the National Health and Nutrition Examination Survey (2003-18) [0.03%]
2003-2018年美国国家健康和营养调查中全氟和多氟化合物与哮喘发病率之间的关联性研究
Allison J Burbank,Rebecca C Fry,Corinne A Keet
Allison J Burbank
Background: Per- and polyfluoroalkyl substances (PFAS) are a class of chemicals widely used in manufacturing and are highly resistant to degradation, so they accumulate in the environment. Serum concentrations of these so...
Model-estimated impacts of pediatric respiratory syncytial virus prevention programs in Mali on asthma prevalence [0.03%]
马里儿科呼吸道合胞病毒预防项目对哮喘患病率影响的模型估算
Justin R Ortiz,Rachel S Laufer,Steven M Brunwasser et al.
Justin R Ortiz et al.
Background: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection (LRTI) in young children and is associated with subsequent recurrent wheezing illness and asthma (wheeze/asthma). RSV p...
Differential T-cell and antibody responses induced by mRNA versus adenoviral vectored COVID-19 vaccines in patients with immunodeficiencies [0.03%]
针对免疫缺陷患者mRNA与腺病毒载体新冠疫苗诱导的差异性T细胞和体液免疫反应
Ernest T Aguinam,Angalee Nadesalingam,Andrew Chan et al.
Ernest T Aguinam et al.
Background: Immunodeficient patients (IDPs) are at higher risk of contracting severe coronavirus disease 2019 (COVID-19). Targeted vaccination strategies have been implemented to enhance vaccine-induced protection. In thi...