Real-world efficacy and safety of omalizumab in chronic spontaneous urticaria: Insights from the Middle East [0.03%]
奥马珠单抗治疗慢性自发性荨麻疹真实世界有效性和安全性的中东地区研究数据及洞见
Shuayb Elkhalifa,Eiman Mahmoud,Fulvio Salvo et al.
Shuayb Elkhalifa et al.
Background: Chronic spontaneous urticaria (CSU) is a mast cell-mediated condition that can cause significant impairment in quality of life. Second-generation H1-antihistamines are recommended as first-line treatment, but ...
Tolerance induction for EGFR TKI hypersensitivity in lung cancer: Case report and review [0.03%]
EGFR TKI过敏性耐受在肺癌中的诱导：病例报告和综述
Mizuha Haraguchi Hashiguchi,Takeya Adachi,Masato Asaoka et al.
Mizuha Haraguchi Hashiguchi et al.
This report highlights the successful use of oral desensitization to manage delayed-type hypersensitivity to afatinib, enabling continuation of treatment for epidermal growth factor receptor-mutated non-small cell lung cancer. In the absenc...
AAAAI physician survey: Current antihistamine use in the clinical setting [0.03%]
美国变态反应、哮喘和免疫学学会成员问卷调查：临床环境中抗组胺药的使用情况
Allison G Hicks,Michael Wu,J Andrew Bird
Allison G Hicks
Background: First-generation antihistamines (FGAs) are less selective for histamine receptor binding than second-generation antihistamines (SGA), with a resulting increased risk for untoward effects. Real-world use data b...
Emerging trends and research hot spots in inborn error of immunity: A bibliometric perspective [0.03%]
先天性免疫缺陷的研究热点及前沿趋势分析——文献计量学视角
Hiba Alblooshi,Muhamad Jalal Khan,Farida Almarzooqi
Hiba Alblooshi
Background: Inborn errors of immunity (IEIs) are an expanding group of genetically defined disorders associated with infections, autoimmunity, and malignancy. Advances in high- throughput genomics and updates to internati...
Pathobiology of atopic dermatitis and association with disease severity after acute oral steroid treatment [0.03%]
特应性皮炎的病理生物学与急性口服糖皮质激素治疗后的疾病严重程度之间的关联
Emma Price,Christiane Whetstone,Dhuha Al-Sajee et al.
Emma Price et al.
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease with complex immune dysregulation. Acute oral corticosteroids relieve measures of AD severity during flares; however, the association of disease se...
Phenotyping treatment-naive uncontrolled asthma in adults: A primary care framework [0.03%]
成人未控制哮喘表型的基层医疗框架（初治哮喘）
Yutaka Nakano,Rika Nakano,Takuya Yukawa et al.
Yutaka Nakano et al.
Background: Initial asthma management often relies on a one-size-fits-all approach; however, the heterogeneity of treatment-naive, uncontrolled asthma remains insufficiently characterized. Specifically, the complex relati...
Hereditary alpha-tryptasemia demonstrates relative basophil enrichment without signs of cellular hyperreactivity [0.03%]
遗传性α-胰蛋白酶血症的特征及其相对嗜碱性粒细胞增多但无细胞活化的迹象
Anna-Karin Johnsson,Ionut Atanasoai,Gunnar Nilsson et al.
Anna-Karin Johnsson et al.
Background: Hereditary alpha-tryptasemia (HαT) is an autosomal dominant trait caused by increased tryptase alpha/beta 1 (TPSAB1) copy number, resulting in elevated serum tryptase levels. Although often asymptomatic, HαT...
Four doses of coronavirus disease 2019 vaccination for patients with inborn errors of immunity compared to 3 doses for healthy individuals [0.03%]
针对原发性免疫缺陷患者的新冠疫苗四剂接种方案与健康人群的三剂接种方案比较研究
Jeffery C H Chan,Samuel M S Cheng,Daniel Leung et al.
Jeffery C H Chan et al.
Background: Patients with inborn errors of immunity (IEI) have high risks of severe complications after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Although vaccination is effective in preventi...
Immunoglobulin replacement therapy in primary immunodeficiency disorders: Pragmatic review and evidence mapping [0.03%]
原发性免疫缺陷病的免疫球蛋白替代治疗：实用回顾和证据地图绘制
Emma Carr,Rachael McCool,Lavinia Ferrante di Ruffano et al.
Emma Carr et al.
Background: Immunoglobulin replacement therapy (IgRT) is used in the treatment of patients with primary immunodeficiency disorders (PIDDs). There are some references to differences between preparations in terms of charact...
Peanut oral immunotherapy at a single academic medical center using a volume-based approach with store-purchased peanut products [0.03%]
基于体积的治疗方法使用市售花生制品进行单中心口腔免疫疗法治疗花生过敏的研究
Ashley L Devonshire,Adam Z Magier,Bridget E Wilson et al.
Ashley L Devonshire et al.
Background: Incorporation of peanut oral immunotherapy (OIT) into clinical practice is increasing, but the approaches used and reported outcomes vary. Obj...