Irradiation does not impact the immunogenicity of food flours used for oral immunotherapy [0.03%]
辐照不影响口服免疫治疗所用食物粉的免疫原性
Timothy P Moran,Anusha Penumarti,Robert M Immormino et al.
Timothy P Moran et al.
Background: Peanut and tree nut flours are considered drug products by the US Food and Drug Administration when used during oral immunotherapy clinical trials and oral food challenges and must meet specific standards for ...
Immune cells influence chronic spontaneous urticaria by inflammatory proteins: Mendelian randomization and bioinformatic analysis [0.03%]
免疫细胞通过炎症蛋白影响自发性慢性荨麻疹：孟德尔随机化和生物信息学分析
Jialu Chen,Yuxu Yao,Lijun Deng et al.
Jialu Chen et al.
Background: Chronic spontaneous urticaria (CSU) is a histamine-mediated inflammatory skin disease, but key inflammatory proteins remain undefined. Objecti...
Limited access to on-demand treatment in hereditary angioedema is linked to delayed treatment and impaired patient-reported outcomes: A multinational real-world study [0.03%]
遗传性血管水肿患者对按需治疗有限的访问与延迟治疗和影响患者的报告结果有关：一项多国真实世界研究
Cathryn F McDougall,Hugo W F Mak,Jane C Y Wong et al.
Cathryn F McDougall et al.
Background: Hereditary angioedema (HAE) is a rare inherited disorder characterized by recurrent episodes of soft tissue swelling. Disparities in HAE care have been described in Asia, Africa, and South America. Less is kno...
Penicillin allergy testing in pregnancy improves maternal and neonatal clinical outcomes [0.03%]
孕期青霉素过敏检测改善了母婴临床结果
Jamie L Waldron,Nerlyne Desravines,Carolina Alvarez et al.
Jamie L Waldron et al.
Background: Penicillin allergy is commonly reported in pregnancy, a time of high antibiotic utilization wherein β-lactam antibiotics have multiple indications. Unverified penicillin allergy leads to alternative antibioti...
Assessing real-world natural history of indolent systemic mastocytosis: A retrospective matched cohort study [0.03%]
惰性系统性mastocytosis的现实世界自然史评估：一项回顾性配对队列研究
Thanai Pongdee,Dakota Powell,Taylor Weis et al.
Thanai Pongdee et al.
Background: Indolent systemic mastocytosis (ISM) is the most common form of systemic mastocytosis, accounting for more than 80% of cases. Patients with ISM experience severe, unpredictable symptoms, including potentially ...
Roberta Almeida Castro Araújo,Claudia Leiko Yonekura Anagusko,Paula Lazaretti Morato Castro et al.
Roberta Almeida Castro Araújo et al.
Background: Cassava allergy is rare; however, because of the cross-reactivity of cassava with latex, it is clinically significant, affecting patient safety and quality of life. Oral immunotherapy (OIT) has been studied fo...
Predicting outcomes of hazelnut oral food challenge: Pediatric cohort analysis [0.03%]
一项预测杏仁口服食物挑战结果的研究：儿童群体分析
Maria Breiding,Veronika Höfer,Alena Kuhn et al.
Maria Breiding et al.
Background: Hazelnut is a common trigger of IgE-mediated food allergy in children, but clinical tolerance remains difficult to predict. While molecular diagnostics and guideline-based cutoffs offer valuable insights, thei...
Self-directed de-escalation of maintenance inhaler therapy in patients with severe asthma in remission with biologic treatment: An observational study [0.03%]
生物制剂治疗的重度哮喘缓解患者的自我指导维持吸入疗法降级：一项观察性研究
Alida Benfante,Alessandra Tomasello,Valentina Catanzaro et al.
Alida Benfante et al.
Background: mAbs targeting type 2 inflammation have significantly improved disease control in severe asthma. As more patients achieve clinical stability, the safety and outcomes of maintenance inhaled therapy (MIT) de-esc...
Characterization and cluster analysis of Indian adults with asthma in the Vellore district [0.03%]
印度威洛尔地区哮喘成人患者的特征及聚类分析
Devasahayam Jesudas Christopher,Jefferson Daniel,Glenis K Scadding et al.
Devasahayam Jesudas Christopher et al.
Background: There is a huge burden of asthma in India, with an estimated 34.3 million patients comprising 13% of the global burden. Little is known about asthma phenotypes, endotypes, and clusters among native Indian pati...
Real-world outcomes and corticosteroid sparing with mepolizumab for EGPA or HES [0.03%]
关于EGPA或HES的美泊利单抗的现实世界结果及其减少皮质类固醇的作用
Michael E Wechsler,Anna Kovalszki,Brian Stone et al.
Michael E Wechsler et al.
Background: Eosinophilic granulomatosis with polyangiitis (EGPA) and hypereosinophilic syndrome (HES) are rare systemic inflammatory diseases with overlapping features. Mepolizumab, a humanized mAb targeting IL-5, has bee...