A computational phenotype for difficult-to-treat asthma with corticosteroid overuse using electronic health care records [0.03%]
基于电子健康档案的难治性哮喘皮质类固醇过度使用计算表型研究
Nikki C C Werkman,Angelique Egberts,Youssra Bais et al.
Nikki C C Werkman et al.
Background: Patients with difficult-to-treat asthma experience insufficient symptom control despite intensive treatment, leading to overuse of oral corticosteroids (OCSs), which is associated with high patient and economi...
NSAID drug hypersensitivity in a United States-based population: An assessment of quality of life [0.03%]
美国人群中的非甾体抗炎药药物过敏：生活质量评估
Smridhi Mahajan,Nikita Batra,John Trickett et al.
Smridhi Mahajan et al.
Background: Nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity reactions are common and can lead to medication avoidance and health anxiety. Obj...
Tree pollen allergen sensitization: Prevalence, risk factors, and geographic variation in the United States [0.03%]
美国树木花粉过敏原致敏的流行病学、危险因素及地域差异
Matthew Robinson,Stanley Letovsky,Andrew H Liu et al.
Matthew Robinson et al.
Background: Many tree pollens are associated with the pathogenesis of allergic disease. Objective: Our aim was to investigate prevalenc...
Probiotics for pediatric atopic dermatitis: A systematic review and meta-analysis of randomized controlled trials [0.03%]
益生菌对儿童特应性皮炎的疗效：随机对照试验的系统评价和meta分析
Muhammad Imran Arif,Qianqian Dai,Liang Ru
Muhammad Imran Arif
Background: Atopic dermatitis is a prevalent chronic inflammatory skin disease in children and the severity of the disease can be affected by modulation of gut microbiota through probiotics. Nonetheless, the clinical tria...
Associations between dietary intake and asthma outcomes: Evidence from pooled analysis in two independent multiethnic Asian cohorts [0.03%]
基于两项独立的多民族亚洲队列研究汇总分析探讨饮食摄入与哮喘结局之间的关联性
Jun Jie Lim,Zongxun Huang,Yu Qi Lee et al.
Jun Jie Lim et al.
Background: Asthma is a chronic respiratory condition that poses significant public health challenges worldwide, including Singapore. Objective: ...
Distinct blood transcriptomic profiling underlying asthma establishment and exacerbation [0.03%]
与哮喘建立和加重相关的不同血液转录组特征
Baojun Wu,Mao Yang,Donglei Hu et al.
Baojun Wu et al.
Background: Non-Hispanic Black individuals are disproportionately affected by asthma and severe asthma exacerbations. To elucidate asthma pathogenesis, it is essential to understand the dysregulated gene expression patter...
Real-world impact of mepolizumab on pediatric and adolescent patients with severe asthma [0.03%]
美柏利珠单抗对重度哮喘患儿的现实世界影响
Michelle L Hernandez,Tom Corbridge,François Laliberté et al.
Michelle L Hernandez et al.
Background: Real-world evidence on the effectiveness of mepolizumab in children and adolescents with severe asthma (SA) is limited. Objective: ...
Anesthetic procedure outcomes after initial perioperative anaphylaxis: A retrospective multicenter US review [0.03%]
美国多中心回顾性研究首次围手术期过敏的麻醉处理及结局
Saiyara S Shama,Ricardo J Estrada-Mendizabal,Christine R F Rukasin et al.
Saiyara S Shama et al.
Background: Limited information exists regarding outcomes during repeat surgical procedures in patients with perioperative anaphylaxis (POA). Although current guidelines recommend that future procedures be guided by aller...
Mutations of MRGPRX2, drug sensitivity, and genetic markers related to disease [0.03%]
MRGPRX2突变、药物敏感性及与疾病相关的遗传标志物
Subashini Hemamala Ratnayake,Kanishka Senarath,Dakshika Gangani et al.
Subashini Hemamala Ratnayake et al.
Mast cells (MCs) express the novel class A Mas-related G protein-coupled receptor X2 (MRGPRX2). Additionally, neurons and other leukocytes including basophils express MRGPRX2. MC activation dependent on IgE is a well-established and extensi...
Improved food allergy and anaphylaxis knowledge and comfort among internal medicine residents following a brief educational intervention [0.03%]
一项简短的教育干预措施改善了内科住院医师对食物过敏和过敏性休克的知识和应对能力
Stephanie Jeong,Scott H Sicherer
Stephanie Jeong
Background: Self-injectable epinephrine (SIE) is the first line of defense against anaphylaxis, a potentially life-threatening allergic reaction commonly triggered by food. Internal medicine residents play a crucial role ...