Biologic effectiveness increases with earlier biologic initiation after severe asthma onset [0.03%]
重度哮喘发作后生物制剂早期引入可提高其疗效
Arjun Mohan,Reynold A Panettieri Jr,Wendy C Moore et al.
Arjun Mohan et al.
Background: Patients with long-standing, uncontrolled, severe asthma can develop airway fibrosis and remodeling due to chronic inflammation, causing irreversible pulmonary damage. ...
Epidemiology, clinical management, and outcomes in patients with eosinophilic granulomatosis with polyangiitis in England: A retrospective observational cohort study [0.03%]
英国嗜酸性粒细胞肉芽肿伴血管炎患者的流行病学、临床管理和预后：一项回顾性队列研究
Salman Siddiqui,Bo Ding,Paul Dolin et al.
Salman Siddiqui et al.
Background: Data on the clinical burden of eosinophilic granulomatosis with polyangiitis (EGPA) are limited. Objective: We sought to ev...
Exercise-induced anaphylaxis with a cofactor of GIP/GLP-1 receptor agonist: A case report [0.03%]
运动诱发的GIP / GLP-1受体激动剂共因子过敏性休克病例报告
Albert C Chong,Amani Elshaer,Maximiliano Diaz-Menindez et al.
Albert C Chong et al.
We report a patient who developed exercise-induced anaphylaxis after starting the dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonist tirzepatide, who after discontinuing tirzepatide, experienced resol...
Genetic variants associated with clinical characteristics and atopies in eosinophilic esophagitis [0.03%]
与嗜酸性食管炎临床特征和特应性相关的遗传变异体
Leticia Rodríguez-Alcolado,Marcos Navares-Gómez,Sergio Casabona-Francés et al.
Leticia Rodríguez-Alcolado et al.
Background: Eosinophilic esophagitis (EoE) and atopy are associated with several genetic variants; however, their relationship with clinical features has been scarcely investigated. ...
AI-based prediction of aspirin-exacerbated respiratory disease using nasal epithelial mRNA expression profiles [0.03%]
基于人工智能的鼻黏膜mRNA表达谱预测阿司匹林加重呼吸系统疾病
Brian D Modena,Mehmet Furkan Bagci,Flavia Hoyte et al.
Brian D Modena et al.
Background: Aspirin-exacerbated respiratory disease (AERD) is a distinct asthma endotype marked by asthma, nasal polyposis, and respiratory reactions to COX-1 inhibitors. Early and accurate identification of AERD remains ...
Early response toward clinical remission with dupilumab in severe asthma: Real-world cohort [0.03%]
Dupixent治疗重度哮喘早期临床缓解的实证队列研究
Kenji Mizumura,Yasuhiro Gon,Akihiko Tanaka et al.
Kenji Mizumura et al.
Background: Clinical remission is an important treatment goal in severe asthma; however, durable remission frameworks generally require sustained disease control over longer periods. Whether dupilumab induces an early res...
Fractional exhaled nitric oxide and blood eosinophils in relation to lung function, allergy and nasal polyps in asthma [0.03%]
呼出气一氧化氮和血嗜酸性粒细胞与哮喘患者的肺功能、过敏和鼻息肉的关系
Reshed Abohalaka,Lauri Lehtimäki,Selin Ercan et al.
Reshed Abohalaka et al.
Background: Type 2 inflammation plays a central role in asthma, but blood eosinophil count (BEC) and fractional exhaled nitric oxide (Feno) levels may reflect different type 2 pathways. Their associations with different a...
Design of allergen-specific inhibitors against shrimp-induced allergic response [0.03%]
虾过敏反应的特异性拮抗剂的设计
Baksun Kim,Emily K Bromley,Jaeho Shin et al.
Baksun Kim et al.
Understanding the experiences of South Asian adults' management of food allergy [0.03%]
南亚成人食物过敏管理体验的理解
Christina J Jones,Clare Stradling,Gurkiran Birdi et al.
Christina J Jones et al.
Background: Population studies suggest lower food allergy (FA) prevalence in South Asia; however, migration to urbanized, Western environments is associated with higher risk of FA among South Asian (SA) individuals, highl...
Ex vivo bradykinin as a functional biomarker for angioedema with normal C1-inhibitor [0.03%]
体外缓激肽作为正常C1抑制剂血管水肿的功能生物标志物
Jinguo Chen,J Joanna Yu,Joseph Chiao et al.
Jinguo Chen et al.
Background: Bradykinin-mediated angioedema (AE-BK) remains diagnostically challenging particularly in patients with normal C1-inhibitor, where diagnosis primarily relies on clinical criteria. Routine laboratory tests can ...