Postoperative acute kidney injury is associated with persistent renal dysfunction: a multicentre propensity-matched cohort study [0.03%]
术后急性肾损伤与持续性肾功能障碍有关：一项多中心倾向匹配队列研究
Blaine Stannard,Richard H Epstein,Eilon Gabel et al.
Blaine Stannard et al.
Background: The risk of developing a persistent reduction in renal function after postoperative acute kidney injury (pAKI) is not well established. The goal of this investigation was to evaluate whether patients who devel...
Neurodevelopment at 10 months and 2-3 years old after early and prolonged anaesthesia in infancy: General Anaesthesia & Brain Activity study (GABA) secondary analysis [0.03%]
婴儿期早期和长期麻醉后10个月至2-3岁神经发育：一般麻醉与脑活动研究(GABA)的二次分析
Laura Cornelissen,Siobhan Coffman,Isabelle Kim et al.
Laura Cornelissen et al.
Background: Effects of early and prolonged exposure to general anaesthesia on the developing brain are unclear. The study objective was to examine developmental outcomes at 10 months and 2-3 yr of age after general anaest...
Premedication with intranasal dexmedetomidine in patients undergoing total knee arthroplasty under spinal anaesthesia (TKADEX)-a prospective, double-blinded, randomised controlled trial [0.03%]
鼻内给药右美托咪定用于硬膜外麻醉行人工膝关节置换术患者的术前用药(TKADEX) -一项前瞻性、双盲随机对照试验
Suvi-Maria Tiainen,Heta Heinonen,Atte Koskinen et al.
Suvi-Maria Tiainen et al.
Background: Previous studies have shown that perioperative use of adjuvants, such as the alpha-2 agonist dexmedetomidine, may reduce postoperative pain and opioid requirements. However, information about optimal dosing is...
The association between elevated preoperative red cell distribution width and worsening kidney function after noncardiac operation. A propensity score and competing risk weighted retrospective cohort study [0.03%]
术前红细胞分布宽度升高与非心脏术后肾功能恶化之间的关联。一项倾向评分和竞争风险加权的回顾性队列研究
Halldór B Olafsson,Sigurbergur Karason,Magnus K Magnusson et al.
Halldór B Olafsson et al.
Background: Elevated red cell distribution width (RDW) is associated with increased postoperative mortality, but less is known about kidney outcomes. This study investigated the association between elevated preoperative R...
Targeted heart rate control using the funny current inhibitor ivabradine to reduce morbidity in patients undergoing noncardiac surgery: study protocol for a phase 2a, triple-blind, placebo-controlled randomised trial [0.03%]
使用funny电流抑制剂伊伐布雷定进行选择性心率控制以减少非心脏手术患者发病率的二期A阶段，三盲，安慰剂对照随机试验的研究方案
Bernardo Bollen Pinto,Benjamin Shelley,Priyanthi Dias et al.
Bernardo Bollen Pinto et al.
Background: Myocardial injury is strongly associated with excess morbidity and mortality after noncardiac surgery. Higher heart rate may result in perioperative myocardial injury through demand-supply mismatch. Alternativ...
Clinical Trial
BJA open. 2025 Feb 19:13:100378. DOI:10.1016/j.bjao.2025.100378 2025
Deep learning models using intracranial and scalp EEG for predicting sedation level during emergence from anaesthesia [0.03%]
使用颅内和头皮EEG的深度学习模型来预测麻醉苏醒期间的镇静水平
Lichy Han,David A Purger,Sarah L Eagleman et al.
Lichy Han et al.
Background: Maintaining an appropriate depth of anaesthesia is important for avoiding adverse effects from undermedication or overmedication during surgery. Electroencephalography (EEG) has become increasingly used to ach...
Peripherally inserted central catheters versus implanted port catheters in patients with breast cancer: a post hoc analysis of the PICCPORT randomised controlled trial [0.03%]
外周插入中心导管与植入式输液端口导管在乳腺癌患者中的比较：PICCPORT随机对照试验的事后分析
Anton Utas,Stefanie Seifert,Knut Taxbro
Anton Utas
Background: Breast cancer is the most prevalent malignancy affecting women. However, the optimal strategy for patients requiring long-term central venous catheters in breast cancer treatment remains uncertain. Previous in...
Frameworks for the design and reporting of anaesthesia interventions in perioperative clinical trials [0.03%]
围术期临床试验中麻醉干预的设计和报告框架
Karen D Coulman,Lucy Elliott,Natalie S Blencowe et al.
Karen D Coulman et al.
Background: Interventions from RCTs can only be replicated and implemented if reported in sufficient detail. This study developed frameworks to assist researchers with describing, monitoring, and reporting the key compone...
Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedication of anxious children (the MAGIC trial) [0.03%]
在儿科围手术和麻醉环境下招募参与者面临的障碍和促进因素：来自一项比较焦虑儿童预处理时使用褪黑素与咪达唑仑的临床试验（MAGIC试验）中的经验教训
Marie C Hyslop,Diana E Papaioannou,Robert Bolt et al.
Marie C Hyslop et al.
Background: Poor recruitment is one key reason for premature closure of randomised controlled trials. The Melatonin for Anxiety prior to General Anaesthesia In Children (MAGIC) trial was a multicentre randomised controlle...
The concerted actions of microRNA-29a and interferon-β modulate complete Freund's adjuvant-induced inflammatory pain by regulating the expression of type 1 interferon receptor, interferon-stimulated gene 15, and p-extracellular signal-regulated kinase [0.03%]
微小核糖核酸-29a和干扰素-β的协同作用通过调节I型干扰素受体、干扰素刺激基因15以及磷酸化细胞外信号调节激酶的表达来调控完全弗氏佐剂诱导的炎性痛
Chien-Cheng Liu,Kuo-Chuan Hung,Yu-Yu Li et al.
Chien-Cheng Liu et al.
Background: Previous research has shown that type 1 interferons (IFN), such as IFN-α and IFN-ß, possess antiviral and antinociception effects. Elevated levels of microRNA-29a (miR-29a) have been observed during inflamma...