Local anaesthetics and chemotherapeutic agents: a systematic review of preclinical evidence of interactions and cancer biology [0.03%]
局部麻醉药和化学治疗剂：关于相互作用和癌症生物学的临床前证据的系统性综述
Ahmed Abdelaatti,Donal J Buggy,Thomas P Wall
Ahmed Abdelaatti
Background: Local anaesthetics are widely used for their analgesic and anaesthetic properties in the perioperative setting, including surgical procedures to excise malignant tumours. Simultaneously, chemotherapeutic agent...
Preoperative fasting and the risk of pulmonary aspiration-a narrative review of historical concepts, physiological effects, and new perspectives [0.03%]
术前禁食与误吸风险-历史观点、生理影响及新视角的叙述性回顾
Anne Rüggeberg,Patrick Meybohm,Eike A Nickel
Anne Rüggeberg
In the early days of anaesthesia, the fasting period for liquids was kept short. By the mid-20th century 'nil by mouth after midnight' had become routine as the principles of the management of 'full stomach' emergencies were extended to inc...
The effects of anaesthesia on cell death in a porcine model of neonatal hypoxic-ischaemic brain injury [0.03%]
麻醉对新生猪缺氧缺血性脑损伤后细胞死亡的影响
Julia K Gundersen,Ela Chakkarapani,David A Menassa et al.
Julia K Gundersen et al.
Background: Hypothermia is neuroprotective after neonatal hypoxic-ischaemic brain injury. However, systemic cooling to hypothermic temperatures is a stressor and may reduce neuroprotection in awake pigs. We compared two e...
Effects of a lower versus a higher oxygenation target in intensive care unit patients with chronic obstructive pulmonary disease and acute hypoxaemic respiratory failure: a subgroup analysis of a randomised clinical trial [0.03%]
慢性阻塞性肺病伴急性低氧性呼吸衰竭患者ICU治疗的低氧合与高氧合目标的效果对比：一项随机临床试验的事后分析研究
Maria B Nielsen,Thomas L Klitgaard,Ulla M Weinreich et al.
Maria B Nielsen et al.
Background: Oxygen supplementation is ubiquitous in intensive care unit (ICU) patients with chronic obstructive pulmonary disease (COPD) and acute hypoxaemia, but the optimal oxygenation target has not been established. ...
The effect of continuous bilateral parasternal block with lidocaine on patient-controlled analgesia opioid requirement and recovery after open heart surgery: a double-blind randomised controlled trial [0.03%]
长效利多卡因双侧胸骨旁神经阻滞对开胸心血管手术后患者自控镇痛阿片类药需求和恢复质量影响的双盲随机对照试验
Mark Larsson,Ulrik Sartipy,Anders Franco-Cereceda et al.
Mark Larsson et al.
Background: We hypothesised that a continuous 72-h bilateral parasternal infusion of lidocaine at 2×35 mg h-1 would decrease pain and the inflammatory response after sternotomy for open heart surgery, subsequently improv...
Daytime dexmedetomidine sedation with closed-loop acoustic stimulation alters slow wave sleep homeostasis in healthy adults [0.03%]
日间右美托咪定镇静联合闭环声刺激调控健康成人慢波睡眠稳态的临床研究
S Kendall Smith,MohammadMehdi Kafashan,Rachel L Rios et al.
S Kendall Smith et al.
Background: The alpha-2 adrenergic agonist dexmedetomidine induces EEG patterns resembling those of non-rapid eye movement (NREM) sleep. Fulfilment of slow wave sleep (SWS) homeostatic needs would address the assumption t...
The role of methadone in cardiac surgery for management of postoperative pain [0.03%]
美沙酮在心脏手术中对术后镇痛管理的作用
Jordan N Edwards,Madeline A Whitney,Bradford B Smith et al.
Jordan N Edwards et al.
Background: This retrospective study evaluated the efficacy and safety of intraoperative methadone compared with short-acting opioids. Methods: ...
Development and validation of a Spanish version of the Obstetric Quality of Recovery-10 item score (ObsQoR-10-Spanish) [0.03%]
西班牙语版产科质量恢复评分表(ObsQoR-10-西班牙语)的开发和验证
Jennifer Guevara,Carlos Sánchez,Jessica Organista-Montaño et al.
Jennifer Guevara et al.
Background: Spanish is the second most spoken language globally with around 475 million native speakers. We aimed to validate a Spanish version of the Obstetric Quality of Recovery-10 item (ObsQoR-10) patient-reported out...
Testing clinical selection criteria for intraoperative transoesophageal echocardiography in isolated coronary artery bypass graft surgery [0.03%]
检测临床选择标准在孤立冠状动脉旁路移植术中术内食管超声的应用
Emily J MacKay,Charlotte J Talham,Bo Zhang et al.
Emily J MacKay et al.
Background: There is a lack of evidence associating intraoperative transoesophageal echocardiography (TOE) use with improved outcomes among coronary artery bypass graft (CABG) surgery subpopulations. ...
Umeshkumar Athiraman,Tusar Giri
Umeshkumar Athiraman
Background: Altered patterns of genetic expression induced by isoflurane preconditioning in mouse brain have not yet been investigated. The aim of our pilot study is to examine the temporal sequence of changes in the tran...