Michelle Shin,Ian Grant,Ramez Mikhail et al.
Michelle Shin et al.
Background: Auditory alarms are crucial in clinical settings, alerting clinicians to events requiring immediate attention. However, multitasking can lead to missed alarms and disrupt patient care. Enhancing auditory alarm...
The ED95 of lidocaine and prilocaine for ultrasound-guided brachial plexus blocks for surgical anaesthesia: a randomised controlled clinical trial [0.03%]
利多卡因和丙胺卡因用于超声引导下臂丛神经阻滞手术麻醉的ED95：随机对照临床试验
Anurag Vats,Pawan K Gupta,Andrew Berrill et al.
Anurag Vats et al.
Background: Our trial addresses the gaps in the current literature by directly estimating the ED95 of short-acting local anaesthetics for ultrasound-guided axillary and supraclavicular brachial plexus blocks for surgical ...
Postoperative acute kidney injury is associated with persistent renal dysfunction: a multicentre propensity-matched cohort study [0.03%]
术后急性肾损伤与持续性肾功能障碍有关：一项多中心倾向匹配队列研究
Blaine Stannard,Richard H Epstein,Eilon Gabel et al.
Blaine Stannard et al.
Background: The risk of developing a persistent reduction in renal function after postoperative acute kidney injury (pAKI) is not well established. The goal of this investigation was to evaluate whether patients who devel...
Neurodevelopment at 10 months and 2-3 years old after early and prolonged anaesthesia in infancy: General Anaesthesia & Brain Activity study (GABA) secondary analysis [0.03%]
婴儿期早期和长期麻醉后10个月至2-3岁神经发育：一般麻醉与脑活动研究(GABA)的二次分析
Laura Cornelissen,Siobhan Coffman,Isabelle Kim et al.
Laura Cornelissen et al.
Background: Effects of early and prolonged exposure to general anaesthesia on the developing brain are unclear. The study objective was to examine developmental outcomes at 10 months and 2-3 yr of age after general anaest...
Premedication with intranasal dexmedetomidine in patients undergoing total knee arthroplasty under spinal anaesthesia (TKADEX)-a prospective, double-blinded, randomised controlled trial [0.03%]
鼻内给药右美托咪定用于硬膜外麻醉行人工膝关节置换术患者的术前用药(TKADEX) -一项前瞻性、双盲随机对照试验
Suvi-Maria Tiainen,Heta Heinonen,Atte Koskinen et al.
Suvi-Maria Tiainen et al.
Background: Previous studies have shown that perioperative use of adjuvants, such as the alpha-2 agonist dexmedetomidine, may reduce postoperative pain and opioid requirements. However, information about optimal dosing is...
The association between elevated preoperative red cell distribution width and worsening kidney function after noncardiac operation. A propensity score and competing risk weighted retrospective cohort study [0.03%]
术前红细胞分布宽度升高与非心脏术后肾功能恶化之间的关联。一项倾向评分和竞争风险加权的回顾性队列研究
Halldór B Olafsson,Sigurbergur Karason,Magnus K Magnusson et al.
Halldór B Olafsson et al.
Background: Elevated red cell distribution width (RDW) is associated with increased postoperative mortality, but less is known about kidney outcomes. This study investigated the association between elevated preoperative R...
Targeted heart rate control using the funny current inhibitor ivabradine to reduce morbidity in patients undergoing noncardiac surgery: study protocol for a phase 2a, triple-blind, placebo-controlled randomised trial [0.03%]
使用funny电流抑制剂伊伐布雷定进行选择性心率控制以减少非心脏手术患者发病率的二期A阶段，三盲，安慰剂对照随机试验的研究方案
Bernardo Bollen Pinto,Benjamin Shelley,Priyanthi Dias et al.
Bernardo Bollen Pinto et al.
Background: Myocardial injury is strongly associated with excess morbidity and mortality after noncardiac surgery. Higher heart rate may result in perioperative myocardial injury through demand-supply mismatch. Alternativ...
Clinical Trial
BJA open. 2025 Feb 19:13:100378. DOI:10.1016/j.bjao.2025.100378 2025
Deep learning models using intracranial and scalp EEG for predicting sedation level during emergence from anaesthesia [0.03%]
使用颅内和头皮EEG的深度学习模型来预测麻醉苏醒期间的镇静水平
Lichy Han,David A Purger,Sarah L Eagleman et al.
Lichy Han et al.
Background: Maintaining an appropriate depth of anaesthesia is important for avoiding adverse effects from undermedication or overmedication during surgery. Electroencephalography (EEG) has become increasingly used to ach...
Peripherally inserted central catheters versus implanted port catheters in patients with breast cancer: a post hoc analysis of the PICCPORT randomised controlled trial [0.03%]
外周插入中心导管与植入式输液端口导管在乳腺癌患者中的比较：PICCPORT随机对照试验的事后分析
Anton Utas,Stefanie Seifert,Knut Taxbro
Anton Utas
Background: Breast cancer is the most prevalent malignancy affecting women. However, the optimal strategy for patients requiring long-term central venous catheters in breast cancer treatment remains uncertain. Previous in...
Frameworks for the design and reporting of anaesthesia interventions in perioperative clinical trials [0.03%]
围术期临床试验中麻醉干预的设计和报告框架
Karen D Coulman,Lucy Elliott,Natalie S Blencowe et al.
Karen D Coulman et al.
Background: Interventions from RCTs can only be replicated and implemented if reported in sufficient detail. This study developed frameworks to assist researchers with describing, monitoring, and reporting the key compone...