Tolerability and efficacy profile of S-ketamine compared with racemic ketamine in surgical patients, a prospective observational before-and-after study in the perioperative setting [0.03%]
右酮替芬与消旋酮替芬在手术患者中的耐受性和疗效的前瞻性观察性前后对照研究
Daniel El Khoury,Amélie Cambriel,Emmanuel Pardo et al.
Daniel El Khoury et al.
Background: While the S-enantiomer of Ketamine (S-Ketamine) is described to be more potent than the racemic form (Ra-Ketamine), with a shorter half-life and almost no side effects, both forms have never been compared in r...
Reply to 'Preoperative anxiety and chronic postsurgical pain: a signal worth acting on, but clinical translation needs greater nuance'. BJA Open 2026; 18: 100558 [0.03%]
对“术前焦虑和术后慢性疼痛：一个需要重视的信号，但临床转化需要更多细微之处”的回复《British Journal of Anaesthesia》2026; 18: 100558
Mirjam Bakker-Bons,André P Wolff,Remko Soer
Mirjam Bakker-Bons
Comment on 'Erector Spinae Plane block with fascial plane catheter for the Early Analgesia of Rib fractures in trauma (ESPEAR): a multicentre feasibility randomised trial' (BJA Open 2025; 16: 100498) [0.03%]
对“用于创伤性肋骨骨折早期镇痛的背伸肌平面阻滞联合筋膜平面导管（ESPEAR）：一项多中心可行性随机试验”的评论(BJA Open 2025; 16: 100498)
Joshua Lucas De Carvalho,Miruna-Maria Horga,Matt Beardmore
Joshua Lucas De Carvalho
Biopsychosocial predictors of chronic pain after caesarean delivery: a prospective cohort evaluation of the SPACE (Sleep, Pain, Affect, Cognition, Energy)-Postpartum framework [0.03%]
SPACE（睡眠、疼痛、情感、认知、活力）产后框架：剖宫产术后慢性疼痛的生物心理社会预测因素的前瞻性队列评价
Sarah Ciechanowicz,Guillermina Michel,Nisha Panigrahy et al.
Sarah Ciechanowicz et al.
Background: Chronic pain after caesarean delivery is associated with impaired maternal quality of life, yet validated risk assessment tools are lacking. We evaluated a novel symptom-based SPACE (Sleep, Pain, Affect, Cogni...
Perioperative thrombin generation and fibrinolytic activation in patients undergoing major gynaecologic surgery for benign and malignant pathology: a pilot study [0.03%]
良性和恶性妇科疾病患者进行大型妇科手术围术期的凝血酶生成及纤溶激活：一项初步研究
Eryn L Thiele,Katherine T Forkin,Kari L Ring et al.
Eryn L Thiele et al.
Background: Perioperative coagulation disturbances are common in major gynaecological surgery, yet differences in thrombin generation (TG) and fibrinolytic activation between malignant and benign pathology remain poorly d...
Preoperative anxiety and chronic postsurgical pain: a signal worth acting on, but clinical translation needs greater nuance [0.03%]
术前焦虑和慢性术后疼痛：一个值得重视的信号，但临床转化需要更多的细微差别
Tuhin Mistry,Abhijit Sukumaran Nair
Tuhin Mistry
Home-based, virtually supported multimodal prehabilitation compared with usual care prior to major surgery: a multicentre, pragmatic pilot randomised trial [0.03%]
基于家庭的、由虚拟支持的多模式手术前康复与重大手术之前的常规护理对比研究：一个多中心实用主义试点随机试验
Daniel I McIsaac,Julie Hallet,Gurlavine Kidd et al.
Daniel I McIsaac et al.
Background: A pragmatic, multicentre randomised trial of virtually supported, home-based prehabilitation is required to evaluate effectiveness in generalisable settings; however, feasibility is unknown. ...
Anaesthesia-related complications after endovascular therapy for acute ischaemic stroke under general anaesthesia with early extubation: A single-centre retrospective cohort study [0.03%]
早期拔管全麻下接受血管内治疗的急性缺血性卒中的麻醉相关并发症：一项单中心回顾性队列研究
Ida Hartor Jensen,Andreas G Damsbo,Jan B Valentin et al.
Ida Hartor Jensen et al.
Background: The optimal anaesthetic strategy for endovascular therapy (EVT) in acute ischaemic stroke (AIS) remains debated. We evaluated the incidence of anaesthesia-related complications, their predictors, and the assoc...
The association between cerebrospinal fluid interleukin-6, soluble interleukin-6 receptor, and interleukin-6 trans-signalling binary complex with postoperative delirium: an observational cohort study [0.03%]
脑脊液白细胞介素-6、可溶性白细胞介素-6受体及白细胞介素-6转换信号二聚复合物与术后谵妄的关联：一项观察性队列研究
Justin G Wu,Jennifer Taylor,David Kunkel et al.
Justin G Wu et al.
Background: Postoperative delirium causes significant morbidity and mortality. Delirium is associated with the presence of plasma and CSF biomarkers, including interleukin-6 (IL-6). When IL-6 binds to the non-membrane-bou...
The impact of adverse childhood experiences on sensory thresholds in adults living with multimorbidity and chronic pain: an observational feasibility study [0.03%]
不利的童年经历对多病共存和慢性疼痛成人患者的感官阈值的影响：一项观察性可行性研究
Dhaneesha N S Senaratne,Blair H Smith,Tim G Hales et al.
Dhaneesha N S Senaratne et al.
Background: Epidemiological studies have linked adverse childhood experiences (ACEs) to multimorbidity and chronic pain. One possible mechanism may be altered sensory processing, which could influence symptom development ...