Chronic activation of the small-conductance, calcium-activated potassium channel precipitates age-dependent depressive-like behavior and cognitive deficits and reduces klotho concentration [0.03%]
SK3钾通道慢性激活诱发年龄相关的抑郁样行为和认知缺陷并降低类脑素浓度
Smn Hasan,D Wan-Yan-Chan,A Hogan et al.
Smn Hasan et al.
Depression is a common mood disorder with a multifaceted, complex pathophysiology. An abnormal level of corticosteroids in the brain can cause structural change in the hippocampus. It may cause an imbalance in calcium homeostasis leading to...
Cognitive inflexibility and immunome biomarkers in children with autism spectrum disorder [0.03%]
自闭症谱系障碍儿童的认知固化和免疫组学标志物
Casara Jean Ferretti,Benjamin Lê Cook,Aakash Mahant Mahant et al.
Casara Jean Ferretti et al.
Cognitive inflexibility is a transdiagnostic endophenotype that presents across a range of disorders, including autism spectrum disorder (ASD), which is maintained through adulthood, and encompasses both cognitive and behavioral rigidity. T...
Cortisol-dependent impairment of dendrite plasticity in human dopaminergic neurons derived from hiPSCs is restored by ketamine: Relevance for major depressive disorders [0.03%]
人多巴胺能神经元中皮质醇依赖性的树突可塑性损伤被氯胺酮逆转：与抑郁症的相关性
Laura Cavalleri,Irene Dassieni,Giulia Sofia Marcotto et al.
Laura Cavalleri et al.
Impaired neuroplasticity in neurons endowed in limbic circuits is considered a hallmark of chronic stress and depression. The reasons for this impairment are still partially unclear, but converging findings suggest that it can be reverted b...
Neurovascular coupling of striatal dopamine D2/3 receptor availability and perfusion using simultaneous PET/MR in humans [0.03%]
人脑中结合正电子发射型计算机断层显影/磁共振成像的多巴胺D2/3受体负荷与血流的神经血管耦合关系研究
Christian N Schmitz,Xenia M Hart,Moritz Spangemacher et al.
Christian N Schmitz et al.
The midbrain dopamine system contributes to important neural functions in the basal ganglia, and is involved in aspects of pathological processes in schizophrenia. In preclinical and clinical studies, pharmacological blockade or stimulation...
Knowledge gaps in psychedelic medicalisation: Clinical studies and regulatory aspects [0.03%]
迷幻剂医学化中的知识缺口：临床研究与监管方面
Drummond E-Wen McCulloch,Matthias E Liechti,Kim Pc Kuypers et al.
Drummond E-Wen McCulloch et al.
Psychedelic drugs including psilocybin and LSD are undergoing clinical trials for a range of psychiatric and neurological conditions, and have particularly shown substantial promise in phase 2 studies of depression. In this article we outli...
Ryad Tamouza,Marion Leboyer,Vincent Vieillard
Ryad Tamouza
Neuroinflammation and peripheral immune dysregulations, affecting both innate and adaptive immune responses, have repeatedly been demonstrated in bipolar disorder (BD). Given the increased susceptibility to infections, the chronic inflammat...
GLP-1 receptor agonist semaglutide reduces appetite while increasing dopamine reward signaling [0.03%]
索马鲁肽激活GLP-1受体减少摄食同时增加多巴胺的奖赏信号
Karlijn L Kooij,Derek IJsbrand Koster,Emma Eeltink et al.
Karlijn L Kooij et al.
Semaglutide, a glucagon-like peptide-1 receptor agonist, is an effective drug reducing body weight and decreasing motivation for palatable food. The mechanisms underlying its effects on food reward remain unclear. We aimed to determine the ...
What influences food choices in anorexia nervosa? Disentangling cognitive and emotional components of decision-making by translational research [0.03%]
进食障碍中的食物选择受什么影响？通过转化研究来区分决策过程中的认知和情感成分
Laura Di Lodovico,Héloise Hamelin,Lucas DeZorzi et al.
Laura Di Lodovico et al.
Anorexia nervosa is a serious mental illness characterized by voluntary restriction of food intake and avoidance of high-calorie food. Anxiety, highly comorbid with anorexia nervosa, appears to be a significant, yet underexplored, factor af...
Safety pharmacology of acute psilocybin administration in healthy participants [0.03%]
健康受试者单次使用裸盖菇素急性给药的安全药理学研究
Isabelle Straumann,Friederike Holze,Anna M Becker et al.
Isabelle Straumann et al.
Psilocybin is being studied for its therapeutic potential in various mental health disorders, such as depression, anxiety, and addiction. Initial studies suggested that psilocybin is generally safe when used under controlled conditions, but...
The dynamic influence of nutrition on prolonged cognitive healthspan across the life course: A perspective review [0.03%]
营养对生命全程持久认知健康跨度的动态影响：述评
Curie Kim,Natalia Schilder,Katie Adolphus et al.
Curie Kim et al.
Cognitive function undergoes a dynamic trajectory across the lifespan, influenced by multifaceted mechanisms encompassing genetics, lifestyle, and environmental factors. This review explores the impact of nutrition, specifically energy and ...