A novel, non-opioid, selective orexin-1 receptor antagonist for the treatment of substance use disorders [0.03%]
一种新型非阿片类选择性下丘脑分泌素-1受体拮抗剂用于治疗物质使用障碍
Clare M Murray,J Craig Fox,Christian Heidbreder et al.
Clare M Murray et al.
There is a pressing need for novel treatments for substance use disorders to address increasing rates of addiction and drug overdose. Preclinical studies have shown that the orexin (hypocretin) system in the brain, mediated primarily by the...
A digital self-help tool to promote mental well-being for Ukrainians affected by war - Assessing predictors of stress [0.03%]
促进战争影响下的乌克兰人心理健康的数字自助工具-评估压力的预测因素
Sofiia Lahutina,Iryna Frankova,Marius Gruen et al.
Sofiia Lahutina et al.
Recent studies show the importance of timing of an intervention in the prevention of mental health disorders followed by exposure to traumatic experiences and lend further support to the concept of the "golden hours". On the second day of t...
Knowledge gaps in psychedelic medicalisation: Preclinical and neuroimaging mechanisms [0.03%]
迷幻药物医学化的知识空白：基础实验和神经影像机制
Drummond E-Wen McCulloch,Juan Pablo Lopez,Christina Dalla et al.
Drummond E-Wen McCulloch et al.
Classical psychedelic drugs, e.g., psilocybin and LSD, stimulate the serotonin 2A receptor (5-HT2AR) and have recently been intensely investigated for their clinical effects in various brain disorders. At the ECNP "New Frontiers meeting" in...
Breaking free from the inflammatory trap of depression: Regulating the interplay between immune activation and plasticity to foster mental health [0.03%]
走出抑郁症的炎症陷阱：调节免疫激活和可塑性的相互作用以促进精神健康
Igor Branchi,Aurelia Viglione,Benedetta Vai et al.
Igor Branchi et al.
Immune alterations have been widely implicated in the onset, progression, and treatment of major depressive disorder. However, our comprehension of the intricate link between immune function and psychopathology remains fragmented and limite...
Chronic activation of the small-conductance, calcium-activated potassium channel precipitates age-dependent depressive-like behavior and cognitive deficits and reduces klotho concentration [0.03%]
SK3钾通道慢性激活诱发年龄相关的抑郁样行为和认知缺陷并降低类脑素浓度
Smn Hasan,D Wan-Yan-Chan,A Hogan et al.
Smn Hasan et al.
Depression is a common mood disorder with a multifaceted, complex pathophysiology. An abnormal level of corticosteroids in the brain can cause structural change in the hippocampus. It may cause an imbalance in calcium homeostasis leading to...
Cognitive inflexibility and immunome biomarkers in children with autism spectrum disorder [0.03%]
自闭症谱系障碍儿童的认知固化和免疫组学标志物
Casara Jean Ferretti,Benjamin Lê Cook,Aakash Mahant Mahant et al.
Casara Jean Ferretti et al.
Cognitive inflexibility is a transdiagnostic endophenotype that presents across a range of disorders, including autism spectrum disorder (ASD), which is maintained through adulthood, and encompasses both cognitive and behavioral rigidity. T...
Cortisol-dependent impairment of dendrite plasticity in human dopaminergic neurons derived from hiPSCs is restored by ketamine: Relevance for major depressive disorders [0.03%]
人多巴胺能神经元中皮质醇依赖性的树突可塑性损伤被氯胺酮逆转：与抑郁症的相关性
Laura Cavalleri,Irene Dassieni,Giulia Sofia Marcotto et al.
Laura Cavalleri et al.
Impaired neuroplasticity in neurons endowed in limbic circuits is considered a hallmark of chronic stress and depression. The reasons for this impairment are still partially unclear, but converging findings suggest that it can be reverted b...
Neurovascular coupling of striatal dopamine D2/3 receptor availability and perfusion using simultaneous PET/MR in humans [0.03%]
人脑中结合正电子发射型计算机断层显影/磁共振成像的多巴胺D2/3受体负荷与血流的神经血管耦合关系研究
Christian N Schmitz,Xenia M Hart,Moritz Spangemacher et al.
Christian N Schmitz et al.
The midbrain dopamine system contributes to important neural functions in the basal ganglia, and is involved in aspects of pathological processes in schizophrenia. In preclinical and clinical studies, pharmacological blockade or stimulation...
Knowledge gaps in psychedelic medicalisation: Clinical studies and regulatory aspects [0.03%]
迷幻剂医学化中的知识缺口：临床研究与监管方面
Drummond E-Wen McCulloch,Matthias E Liechti,Kim Pc Kuypers et al.
Drummond E-Wen McCulloch et al.
Psychedelic drugs including psilocybin and LSD are undergoing clinical trials for a range of psychiatric and neurological conditions, and have particularly shown substantial promise in phase 2 studies of depression. In this article we outli...
Ryad Tamouza,Marion Leboyer,Vincent Vieillard
Ryad Tamouza
Neuroinflammation and peripheral immune dysregulations, affecting both innate and adaptive immune responses, have repeatedly been demonstrated in bipolar disorder (BD). Given the increased susceptibility to infections, the chronic inflammat...