Comparative effectiveness of long-acting injectable antipsychotics in a large naturalistic cohort across two European centers: Findings from the long-acting injectable antipsychotics collaborative (LAICO) study [0.03%]
欧洲两大中心自然队列中长效抗精神病药物的疗效比较：来自长效注射用抗精神病药物协作组（LAICO）研究的结果
Juan Antonio García-Carmona,Joshua Barnett,María Pilar Campos-Navarro et al.
Juan Antonio García-Carmona et al.
We aimed to evaluate and compare the use of the paliperidone palmitate-1 and 3-month (PP1M, PP3M), aripiprazole 1-month (A1M) and risperidone-LAI (RLAI) LAIs, using the following clinical outcomes: (1) the number of hospital admissions, (2)...
Microdosing with psychedelics to self-medicate for ADHD symptoms in adults: A prospective naturalistic study [0.03%]
成人使用微量迷幻剂自我治疗注意力缺陷多动障碍症状的前瞻性自然主义研究
Eline C H M Haijen,Petra P M Hurks,Kim P C Kuypers
Eline C H M Haijen
ADHD in adulthood is often overlooked, which negatively affects the individual's well-being. First-line pharmacological interventions are effective in many ADHD patients, relieving symptoms rapidly. However, there seems to be a proportion o...
A single subanaesthetic dose of the rapid-acting antidepressant S-ketamine raises presynaptic SV2A density in limbic regions of the Wistar Kyoto rat model of depression [0.03%]
单剂量麻醉剂S-氯胺酮升高抑郁模型Wistar大鼠 limbic脑区突触前SV2A密度
Simone Larsen Bærentzen,Anna Lee Waszkiewicz,Majken Thomsen et al.
Simone Larsen Bærentzen et al.
The N-methyl-D-aspartate receptor (NMDA-R) antagonist S-ketamine has been approved as a rapid-acting antidepressant for treatment-resistant depression (TRD). The antidepressant mechanisms have not fully been elucidated; however, alterations...
Polygenic scores of subcortical brain volumes as possible modulators of treatment response in depression [0.03%]
抑郁症的亚皮层脑体积多基因评分作为可能的治疗反应调节因子
Vincenzo Oliva,Alfonso Martone,Giuseppe Fanelli et al.
Vincenzo Oliva et al.
A significant proportion of patients with major depressive disorder (MDD) do not experience remission after one or more pharmacological treatments. Research has explored brain structural measures, particularly hippocampal volume, as potenti...
Neurobiological traces of grief: Examining the impact of offspring loss after birth on rat mothers' brain and stress-coping behavior in the first week postpartum [0.03%]
丧子对母亲的影响：产后初生幼鼠丧子对母鼠大脑和应对压力的行为影响的神经生物学痕迹研究
Luisa Demarchi,Alice Sanson,Oliver J Bosch
Luisa Demarchi
The bond between a mother and her infant is one of the strongest social bonds found in mammals. Consequently, the loss of an infant has immense psychological and physiological effects on the caregiver. Despite the significance of this berea...
A novel, non-opioid, selective orexin-1 receptor antagonist for the treatment of substance use disorders [0.03%]
一种新型非阿片类选择性下丘脑分泌素-1受体拮抗剂用于治疗物质使用障碍
Clare M Murray,J Craig Fox,Christian Heidbreder et al.
Clare M Murray et al.
There is a pressing need for novel treatments for substance use disorders to address increasing rates of addiction and drug overdose. Preclinical studies have shown that the orexin (hypocretin) system in the brain, mediated primarily by the...
A digital self-help tool to promote mental well-being for Ukrainians affected by war - Assessing predictors of stress [0.03%]
促进战争影响下的乌克兰人心理健康的数字自助工具-评估压力的预测因素
Sofiia Lahutina,Iryna Frankova,Marius Gruen et al.
Sofiia Lahutina et al.
Recent studies show the importance of timing of an intervention in the prevention of mental health disorders followed by exposure to traumatic experiences and lend further support to the concept of the "golden hours". On the second day of t...
Knowledge gaps in psychedelic medicalisation: Preclinical and neuroimaging mechanisms [0.03%]
迷幻药物医学化的知识空白：基础实验和神经影像机制
Drummond E-Wen McCulloch,Juan Pablo Lopez,Christina Dalla et al.
Drummond E-Wen McCulloch et al.
Classical psychedelic drugs, e.g., psilocybin and LSD, stimulate the serotonin 2A receptor (5-HT2AR) and have recently been intensely investigated for their clinical effects in various brain disorders. At the ECNP "New Frontiers meeting" in...
Breaking free from the inflammatory trap of depression: Regulating the interplay between immune activation and plasticity to foster mental health [0.03%]
走出抑郁症的炎症陷阱：调节免疫激活和可塑性的相互作用以促进精神健康
Igor Branchi,Aurelia Viglione,Benedetta Vai et al.
Igor Branchi et al.
Immune alterations have been widely implicated in the onset, progression, and treatment of major depressive disorder. However, our comprehension of the intricate link between immune function and psychopathology remains fragmented and limite...
Chronic activation of the small-conductance, calcium-activated potassium channel precipitates age-dependent depressive-like behavior and cognitive deficits and reduces klotho concentration [0.03%]
SK3钾通道慢性激活诱发年龄相关的抑郁样行为和认知缺陷并降低类脑素浓度
Smn Hasan,D Wan-Yan-Chan,A Hogan et al.
Smn Hasan et al.
Depression is a common mood disorder with a multifaceted, complex pathophysiology. An abnormal level of corticosteroids in the brain can cause structural change in the hippocampus. It may cause an imbalance in calcium homeostasis leading to...