The potential of neuromelanin-sensitive MRI in psychiatric disorders [0.03%]
神经黑素敏感性磁共振成像在精神病学疾病中的应用前景
Eline Neutelings,Elsmarieke van de Giessen,Lieuwe de Haan et al.
Eline Neutelings et al.
Psychiatric disorders represent a significant public health concern due to their high prevalence and lifelong substantial impact. Despite advances in understanding their neurobiological underpinnings, the transdiagnostic mechanisms driving ...
Sleep, Steps, and Screens: Between- and within-person effects of digital markers of daily life behaviors on smartphone-based assessments of cognitive functioning in depression [0.03%]
睡眠，步数和屏幕：日常行为的数字化标记在抑郁症手机认知功能评估间的和个体内效应
Marcos Ross-Adelman,George Aalbers,Faith Matcham et al.
Marcos Ross-Adelman et al.
Cognitive impairment represents a core feature of major depressive disorder (MDD), often persisting after mood symptoms remit and not addressed by usual antidepressant treatments. Despite its relevance, cognition is typically assessed with ...
Sultan Ekinci,Hidayet Ece Arat Çelik,İbrahim Fettahoğlu et al.
Sultan Ekinci et al.
Bipolar disorder (BD) has been associated with accelerated biological aging, potentially driven by genetic and environmental factors. Long non-coding RNAs (lncRNAs), key regulators of epigenetic, telomere attrition, and cellular aging proce...
Differentiation of human iPSCs into dopaminergic neurons: comparative analysis of 2D and 3D protocols for disease modeling and pharmacology [0.03%]
人多能干细胞向多巴胺能神经元的分化：疾病模型和药理学中的二维和三维协议比较分析
Giulia Sofia Marcotto,Jonida Bitraj,Emilio Merlo Pich et al.
Giulia Sofia Marcotto et al.
This pragmatic review addresses those protocols containing innovative steps for differentiating human inducible Pluripotent Stem Cells (iPSCs) into mature midbrain dopaminergic (mDA) neurons, leading to successful implementation in other ar...
Response to immune-based augmentation treatment for depression: a potential role of immunosenescence [0.03%]
免疫衰老在基于免疫增强治疗的抑郁症应答中的潜在作用
Evelien Van Assche,Christa Hohoff,Sophia M Wissing et al.
Evelien Van Assche et al.
Immunological processes are increasingly in focus as factors contributing to major depressive disorder (MDD). Especially subtypes such as immunometabolic depression phenotypes have been linked to low-grade inflammation. Augmentation with im...
Balanced polyunsaturated fatty acids diet prevents the D-galactose-induced neuroinflammation and cognitive impairments [0.03%]
平衡的多不饱和脂肪酸饮食可以预防D-半乳糖所致的神经炎症和认知障碍
Ivan Marniquet,Juliette Dupont-Viratelle,Flavie Crespo et al.
Ivan Marniquet et al.
The rapid increase of the population aged 65 and over is associated with a higher prevalence of people suffering from cognitive functions alterations. Those impairments are partly due to environmental risk factors such as nutrition. In this...
Virtual reality-based cognitive screening in psychiatry: Investigating optimal cut-offs for cognitive impairment in bipolar disorder [0.03%]
基于虚拟现实的认知筛查在精神病学中的应用：调查双相情感障碍认知损害的最优界点
Andreas Elleby Jespersen,Julie Marie Lindhardsen,Anders Lumbye et al.
Andreas Elleby Jespersen et al.
Cognitive impairment is a key treatment target across neuropsychiatric disorders, including bipolar disorder (BD), but standard neuropsychological tools often fail to capture real-world cognitive challenges. Virtual reality (VR) offers a mo...
Old enough to be a model? On the role of maturity in stem cell-based models for neuropsychiatric disorders [0.03%]
足够的成为模型吗？关于成熟度在神经精神疾病干细胞模型中的作用
Bingqing He,Erik Smedler
Bingqing He
Mental disorders profoundly influence cognition, emotion, and self-perception, and collectively represent a major cause of global disability. Their onset spans distinct developmental periods, from early childhood in neurodevelopmental condi...
Promoting brain health across the lifespan: Socioeconomic burden, global recommendations, and the Spanish national plan [0.03%]
毕生脑健康促进：社会经济负担、全球建议及西班牙国家计划
Verónica Robles,Meritxell Valentí,Mar Mendibe et al.
Verónica Robles et al.
Neurological and mental health disorders substantially reduce life expectancy and represent a major public health and socioeconomic burden in Europe, accounting for a significant proportion of disability and productivity loss. In Spain, con...