Application of the research domain criteria in early-phase clinical development of transdiagnostic neurotherapeutics: A multidisciplinary perspective [0.03%]
跨诊断神经治疗早期临床开发中研究领域标准的应用：多学科视角
Igor Magaraggia,Franco Di Cesare,Jordi Alonso et al.
Igor Magaraggia et al.
Transdiagnostic, dimensional frameworks such as the Research Domain Criteria (RDoC) are increasingly regarded as promising vehicles for precision neuropsychiatric drug development, yet no treatment has been approved that was explicitly deve...
Supporting mental health in war: Knowledge transfer through ECNP traumatic stress network webinars [0.03%]
战时支持心理健康：通过ECNP创伤应激网络研讨会进行知识转移
Iryna Frankova,Eric Vermetten,Olena Zhabenko et al.
Iryna Frankova et al.
On February 24, 2022, Russia's invasion of Ukraine marked a significant escalation of the armed conflict that began in 2014. In response, Traumatic Stress Network of the European College of Neuropsychopharmacology (ECNP) launched the "Hot T...
Data welfare is animal welfare: Building a WellFAIR research ecosystem [0.03%]
数据福祉即动物福祉：构建WellFAIR研究生态系统
Benoit Petit-Demoulière,Damien Huzard
Benoit Petit-Demoulière
Statistical process control for real-time monitoring in clinical psychology: State of the art and future research agenda [0.03%]
临床心理学实时监测的统计过程控制：现状与未来研究方向
Evelien Schat,Marieke J Schreuder,Eva Ceulemans
Evelien Schat
Mental disorders place a substantial burden on individuals and society, underscoring the need for preventive interventions that can be delivered to the right person at the right time. This, in turn, requires real-time monitoring of person-s...
Integrating physical healthcare into psychiatry for severe mental illness: A narrative review and position statement from the ECNP PAN-Health group [0.03%]
严重精神疾病的心理治疗中融入物理保健：ECNP PAN-健康小组的叙事性评审与立场声明
René Ernst Nielsen,Heidi Taipale,Samuele Cortese et al.
René Ernst Nielsen et al.
Individuals with severe mental illness (SMI) face significantly reduced life expectancy, mainly driven by natural causes such as cardiovascular disease, pulmonary disease, cancer, and stroke. Although medical care has advanced, the mortalit...
The potential of neuromelanin-sensitive MRI in psychiatric disorders [0.03%]
神经黑素敏感性磁共振成像在精神病学疾病中的应用前景
Eline Neutelings,Elsmarieke van de Giessen,Lieuwe de Haan et al.
Eline Neutelings et al.
Psychiatric disorders represent a significant public health concern due to their high prevalence and lifelong substantial impact. Despite advances in understanding their neurobiological underpinnings, the transdiagnostic mechanisms driving ...
Sleep, Steps, and Screens: Between- and within-person effects of digital markers of daily life behaviors on smartphone-based assessments of cognitive functioning in depression [0.03%]
睡眠，步数和屏幕：日常行为的数字化标记在抑郁症手机认知功能评估间的和个体内效应
Marcos Ross-Adelman,George Aalbers,Faith Matcham et al.
Marcos Ross-Adelman et al.
Cognitive impairment represents a core feature of major depressive disorder (MDD), often persisting after mood symptoms remit and not addressed by usual antidepressant treatments. Despite its relevance, cognition is typically assessed with ...
Sultan Ekinci,Hidayet Ece Arat Çelik,İbrahim Fettahoğlu et al.
Sultan Ekinci et al.
Bipolar disorder (BD) has been associated with accelerated biological aging, potentially driven by genetic and environmental factors. Long non-coding RNAs (lncRNAs), key regulators of epigenetic, telomere attrition, and cellular aging proce...
Differentiation of human iPSCs into dopaminergic neurons: comparative analysis of 2D and 3D protocols for disease modeling and pharmacology [0.03%]
人多能干细胞向多巴胺能神经元的分化：疾病模型和药理学中的二维和三维协议比较分析
Giulia Sofia Marcotto,Jonida Bitraj,Emilio Merlo Pich et al.
Giulia Sofia Marcotto et al.
This pragmatic review addresses those protocols containing innovative steps for differentiating human inducible Pluripotent Stem Cells (iPSCs) into mature midbrain dopaminergic (mDA) neurons, leading to successful implementation in other ar...
Response to immune-based augmentation treatment for depression: a potential role of immunosenescence [0.03%]
免疫衰老在基于免疫增强治疗的抑郁症应答中的潜在作用
Evelien Van Assche,Christa Hohoff,Sophia M Wissing et al.
Evelien Van Assche et al.
Immunological processes are increasingly in focus as factors contributing to major depressive disorder (MDD). Especially subtypes such as immunometabolic depression phenotypes have been linked to low-grade inflammation. Augmentation with im...