Neural correlates of cognitive improvement over time in patients newly diagnosed with bipolar disorder [0.03%]
双相情感障碍新发患者随时间认知改善的神经相关性研究
Hanne Lie Kjærstad,Sebastian Vestergaard Segerlin,Julian Macoveanu et al.
Hanne Lie Kjærstad et al.
There is currently no known effective long-term treatment for cognitive impairments in bipolar disorder (BD) and understanding of the neurobiological mechanisms underlying cognitive impairments in BD is lacking. Identifying potential biomar...
Microbial tryptophan metabolites modulate blood-brain and gut barriers in vitro [0.03%]
微生物代谢产物调节血脑屏障及肠道屏障（体外模型）
Cristina Rosell-Cardona,Emily G Knox,Paula Sánchez-Díaz et al.
Cristina Rosell-Cardona et al.
The gut microbiota influences brain function via the gut-brain axis, but the underlying molecular processes remain unclear. Critical to this communication are barrier systems, such as the epithelial gut and the blood-brain barrier, which me...
Comparing personalized and population-based models for predicting momentary negative affect in internalizing disorders: A digital phenotyping study [0.03%]
针对焦虑症和抑郁症的数字化表型研究：个体化模型与群体模型在预测即刻负面情绪方面的比较分析
Leona Hammelrath,Roshan Prakash Rane,Sam Gijsen et al.
Leona Hammelrath et al.
Negative affect (NA), encompassing heightened states of sadness, anxiety, and guilt, is a key symptom across a spectrum of internalizing disorders. Recent advancements in digital phenotyping (DP) and machine learning (ML) may enable the aut...
Striking a balance: A proposed benefit assessment matrix for ethical animal research [0.03%]
求同存异：构建伦理动物研究效益评估矩阵以实现各方共赢
Anton Bespalov,Ulrich Dirnagl,Chantelle Ferland-Beckham et al.
Anton Bespalov et al.
The debate about the continued use of animals in research has intensified in recent years, with few signs that consensus can be achieved in the near future. Animal activist groups and their supporters call for an immediate halt to all anima...
Digital tools for assessing bipolar disorder: A scoping review of the current landscape [0.03%]
评估双相情感障碍的数字工具：当前格局综述
Samantha Jacobson,Hannah Carling,Lisa Sarraf et al.
Samantha Jacobson et al.
This scoping review synthesizes current evidence on the use of digital tools to assess bipolar disorder across clinical, behavioral, physiological, and psychosocial domains. An electronic search of Ovid, CINAHL, ClinicalTrials.gov, and Open...
Special characteristics of human astrocytes and their roles in brain homeostasis [0.03%]
人类星形胶质细胞的特殊特征及其在脑内稳态中的作用
Ilari Kousa,Karo Talvio,Ulla-Kaisa Peteri et al.
Ilari Kousa et al.
Human astrocytes differ morphologically, functionally, and in their gene expression patterns from murine astrocytes. The astrocytic heterogeneity and complexity observed in the mouse brain are multiplied in humans, evident in primate-specif...
Machine learning for immune biomarkers in severe mental illness: a systematic review [0.03%]
精神疾病免疫生物标志物的机器学习研究：系统综述
Rayan Slatni,Federica Colombo,Paolo Enrico et al.
Rayan Slatni et al.
The integration of machine learning (ML) approaches with immune biomarker research may facilitate the identification of candidate markers for achieving personalized medicine approaches in severe mental illnesses (SMI). This systematic revie...
Critical uncertainties in preclinical research: Navigating trust, technology, and ethics [0.03%]
前期研究中的关键不确定性：信任、技术与伦理的考量
Indrek Heinla,Vootele Voikar,Hilary Gates et al.
Indrek Heinla et al.
Animal use in preclinical research is facing growing scientific, ethical and political scrutiny in Europe. Researchers are increasingly required to justify in vivo studies and are urged to replace them with New Approach Methodologies (NAMs)...
Positive effects of brief body exercises on mood: An interventional EMA study [0.03%]
简短的身体锻炼对情绪的积极影响：一种干预式体验抽样研究
Lea Nitzpon,Johanna Rehder,Richard Hohmann et al.
Lea Nitzpon et al.
Short bouts of physical activity in daily life are associated with affective well-being and may promote mental health. However, the causality and differential effects of distinct physical activity types remain unknown. This study investigat...
Weight matters: Higher BMI is associated with changes in the brain connectome in health and depression [0.03%]
体重很重要：较高的BMI与健康和抑郁状态下的大脑连接组变化有关
Aicha Bouzouina,Marius Gruber,Tong Zhao et al.
Aicha Bouzouina et al.
Overweight and obesity are bidirectionally associated with major depressive disorder (MDD). However, the underlying mechanisms remain unknown. Here, we investigated whether the body mass index (BMI) is associated with alterations in the str...