Negative symptoms in schizophrenia: Methodological challenges and emerging solutions for outcome measurement [0.03%]
精神分裂症的阴性症状：结局测量的方法挑战和新兴解决方案
Armida Mucci,Michael Davidson,Silvia Zaragoza Domingo et al.
Armida Mucci et al.
Negative symptoms (NS) affect approximately 60% of individuals with schizophrenia and are associated with poor outcomes. They remain an important unmet therapeutic need, not adequately addressed by available antipsychotic drugs, and they ar...
Linking inflammatory and structural neuroimaging biomarkers in treatment-resistant depression: Current evidence and emerging hypotheses [0.03%]
难治性抑郁炎症与结构影像学生物标志物的关联：现有证据和新兴假说
Simge Seren Kirlioglu Balcioglu,Marco Paolini,Bernhard T Baune et al.
Simge Seren Kirlioglu Balcioglu et al.
•TRD is associated with immune alterations across peripheral and central domains.•TRD may show hippocampal and white matter changes that may be linked to immune-related processes.•Integrating immune and neuroimaging findings may contribu...
From health to harm: Cross-sectional analysis of factors associated with orthorexia nervosa [0.03%]
从健康到伤害：正饮食障碍相关因素横断面分析
Annika M Roth,Regina Vollmeyer,Silke Matura
Annika M Roth
The present study systematically examined factors associated with orthorexic tendencies, to provide a clearer understanding of this phenomenon. In a cross-sectional setting, data were collected using an online questionnaire including valida...
Examining varying number of intervention-modules and change in individual networks in young people remitted from depression or anxiety: Exploratory outcomes of the StayFine randomized clinical trial [0.03%]
针对抑郁或焦虑缓解期青年的不同干预模块数量及个体网络变化的考察——来自StayFine随机临床试验的探索性结果
S J Robberegt,C J Albers,B E A M Kooiman et al.
S J Robberegt et al.
In network theory, symptoms of mental disorders constitute networks of interconnected nodes. Interventions can target (aspects of) networks. Assuming that combined intervention-modules target multiple aspects of networks simultaneously, we ...
The effects of omega-3 fatty acids on Wnt activity in iPSC-derived neural stem cells from adult ADHD patients [0.03%]
欧米茄-3脂肪酸对多动症成人患者诱导多功能干细胞来源的神经干细中Wnt活性的影响
Cristine M Yde Ohki,Natalie M Walter,Louisa C Dury et al.
Cristine M Yde Ohki et al.
The canonical Wnt signaling pathway plays a key role in neurodevelopment and in maintaining cellular homeostasis of the central nervous system in adulthood. It regulates essential processes, such as cell proliferation, differentiation, and ...
Neural correlates of cognitive improvement over time in patients newly diagnosed with bipolar disorder [0.03%]
双相情感障碍新发患者随时间认知改善的神经相关性研究
Hanne Lie Kjærstad,Sebastian Vestergaard Segerlin,Julian Macoveanu et al.
Hanne Lie Kjærstad et al.
There is currently no known effective long-term treatment for cognitive impairments in bipolar disorder (BD) and understanding of the neurobiological mechanisms underlying cognitive impairments in BD is lacking. Identifying potential biomar...
Microbial tryptophan metabolites modulate blood-brain and gut barriers in vitro [0.03%]
微生物代谢产物调节血脑屏障及肠道屏障（体外模型）
Cristina Rosell-Cardona,Emily G Knox,Paula Sánchez-Díaz et al.
Cristina Rosell-Cardona et al.
The gut microbiota influences brain function via the gut-brain axis, but the underlying molecular processes remain unclear. Critical to this communication are barrier systems, such as the epithelial gut and the blood-brain barrier, which me...
Comparing personalized and population-based models for predicting momentary negative affect in internalizing disorders: A digital phenotyping study [0.03%]
针对焦虑症和抑郁症的数字化表型研究：个体化模型与群体模型在预测即刻负面情绪方面的比较分析
Leona Hammelrath,Roshan Prakash Rane,Sam Gijsen et al.
Leona Hammelrath et al.
Negative affect (NA), encompassing heightened states of sadness, anxiety, and guilt, is a key symptom across a spectrum of internalizing disorders. Recent advancements in digital phenotyping (DP) and machine learning (ML) may enable the aut...
Striking a balance: A proposed benefit assessment matrix for ethical animal research [0.03%]
求同存异：构建伦理动物研究效益评估矩阵以实现各方共赢
Anton Bespalov,Ulrich Dirnagl,Chantelle Ferland-Beckham et al.
Anton Bespalov et al.
The debate about the continued use of animals in research has intensified in recent years, with few signs that consensus can be achieved in the near future. Animal activist groups and their supporters call for an immediate halt to all anima...
Digital tools for assessing bipolar disorder: A scoping review of the current landscape [0.03%]
评估双相情感障碍的数字工具：当前格局综述
Samantha Jacobson,Hannah Carling,Lisa Sarraf et al.
Samantha Jacobson et al.
This scoping review synthesizes current evidence on the use of digital tools to assess bipolar disorder across clinical, behavioral, physiological, and psychosocial domains. An electronic search of Ovid, CINAHL, ClinicalTrials.gov, and Open...