Protocol for a randomised controlled trial on smartphone- and web-based app for precision dosing and monitoring of lithium («PharmOracle») for improving adherence to therapy in patients with bipolar affective disorder or schizoaffective disorder [0.03%]
智能手机与网络应用程序锂精确诊断和监测（“PharmOracle”）改善双相情感障碍或分裂情感障碍患者治疗依从性的随机对照试验方案
Kirill Markin,Arslan Moritz,Ekaterina Gerasimchuk et al.
Kirill Markin et al.
Lithium remains a first-line treatment for bipolar disorder but its use is declining owing to the need for intensive monitoring and concerns about tolerability. Digital decision-support tools that combine model-informed precision dosing, Ba...
MicroRNAs expression changes associated with trauma-focused psychotherapy efficacy in treatment-resistant depression: An exploratory study [0.03%]
难治性抑郁患者创伤聚焦心理治疗疗效相关的microRNA表达改变的探索性研究
Lisa Buson,Rosana Carvalho Silva,Chiara Galbiati et al.
Lisa Buson et al.
Early life stress (ELS) increases vulnerability to major depressive disorder (MDD) and treatment-resistant depression (TRD) through lasting neurobiological and epigenetic alterations. MicroRNAs (miRNAs), key post-transcriptional regulators ...
Outcome strategies for clinical trials in Neuropaediatric rare diseases [0.03%]
神经儿科罕见病临床试验的结局选择策略分析
Maria Teresa Acosta,José Ángel Aibar,Celso Arango et al.
Maria Teresa Acosta et al.
Neuropaediatric Rare Diseases (NRDs) impose a profound and multidimensional burden on patients, families, and healthcare systems. Persistently low clinical trial success rates reflect an unmet methodological need as much as a therapeutic on...
In utero air pollution exposure and pre- and postnatal brain development: a review [0.03%]
孕期空气污染暴露与胎儿及婴幼儿脑发育关系研究进展综述
Vera Goossens,Nora L Großmann,Ulrike Gehring et al.
Vera Goossens et al.
Air pollution is a major threat to public health globally and may also adversely influence brain development. Key neurodevelopmental processes unfold within narrow and sensitive windows during fetal life and continue through childhood and a...
Investigating behavioral inertia in passively sensed smartphone parameters to differentiate affective episodes in patients with bipolar disorder [0.03%]
探究行为惯性在被动感知的智能手机参数中区分双相情感障碍患者的发作期和间歇期的行为研究
E M Langner,C Bittendorf,E Mühlbauer et al.
E M Langner et al.
Bipolar disorders are severe, recurrent mental illnesses characterized by distinct mood states associated with different behavioral patterns. While (emotional) inertia, the tendency of a system to persist or change, has been linked to depre...
Shared genetic architecture between psychiatric and insulin-related traits in the general population [0.03%]
精神病学和胰岛素相关特征之间共享的遗传结构：普适人群中的研究
Barbara Šakić,Izel Erdogan,Giuseppe Fanelli et al.
Barbara Šakić et al.
Psychiatric conditions, like Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), and Obsessive-Compulsive Disorder (OCD) are complex heritable disorders that frequently co-occur with insulin resistance (IR)-rela...
Bipolar disorder and somatic diseases: Focus on oxidative stress markers [0.03%]
双相情感障碍与躯体疾病：重点探讨氧化应激标志物
Sinem Balaç,İzel Cemre Aksahin,Hidayet Ece Arat-Çelik et al.
Sinem Balaç et al.
Bipolar disorder (BD) is associated with a substantial burden of somatic diseases, including cardiovascular, neurodegenerative, and inflammatory conditions. However, the biological continuity linking the core pathophysiology of BD to these ...
Clinical trials in neurosciences: Need for standards for innovation on clinical outcomes [0.03%]
神经科学临床试验创新的临床结果标准需求
Silvia Zaragoza Domingo,Amy Pinkham,Daniella Tinoco et al.
Silvia Zaragoza Domingo et al.
Advances in understanding neurobiological factors underlying neurologic and psychiatric conditions have yet to be adequately translated into successful treatments. In neuroscience therapeutic areas, a high percentage of clinical trials fail...
Involvement of persons with lived experience in mental health research: recommendations [0.03%]
精神健康研究中纳入有亲身经历者的意见：指导意见
K Kleine Schaars,Allan H Young,Ramona Moldovan et al.
K Kleine Schaars et al.
Although the benefits of involvement of persons with lived experience in mental health research have been widely demonstrated, consistent implementation remains challenging. During the 36th ECNP congress in Barcelona, a session was hosted, ...
Olfactory impairment in Huntington's disease: A systematic review and meta-analysis [0.03%]
亨廷顿病嗅觉障碍的系统评价和meta分析
Franco Di Cesare,Cristiana Di Carlo,Leonardo Di Cesare et al.
Franco Di Cesare et al.
Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder characterised by progressive impairment in cognitive, behavioural, and motor functions. Odour identification deficits have long been recognised as a non-motor imp...