Shared genetic architecture between psychiatric and insulin-related traits in the general population [0.03%]
精神病学和胰岛素相关特征之间共享的遗传结构：普适人群中的研究
Barbara Šakić,Izel Erdogan,Giuseppe Fanelli et al.
Barbara Šakić et al.
Psychiatric conditions, like Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), and Obsessive-Compulsive Disorder (OCD) are complex heritable disorders that frequently co-occur with insulin resistance (IR)-rela...
Bipolar disorder and somatic diseases: Focus on oxidative stress markers [0.03%]
双相情感障碍与躯体疾病：重点探讨氧化应激标志物
Sinem Balaç,İzel Cemre Aksahin,Hidayet Ece Arat-Çelik et al.
Sinem Balaç et al.
Bipolar disorder (BD) is associated with a substantial burden of somatic diseases, including cardiovascular, neurodegenerative, and inflammatory conditions. However, the biological continuity linking the core pathophysiology of BD to these ...
Clinical trials in neurosciences: Need for standards for innovation on clinical outcomes [0.03%]
神经科学临床试验创新的临床结果标准需求
Silvia Zaragoza Domingo,Amy Pinkham,Daniella Tinoco et al.
Silvia Zaragoza Domingo et al.
Advances in understanding neurobiological factors underlying neurologic and psychiatric conditions have yet to be adequately translated into successful treatments. In neuroscience therapeutic areas, a high percentage of clinical trials fail...
Involvement of persons with lived experience in mental health research: recommendations [0.03%]
精神健康研究中纳入有亲身经历者的意见：指导意见
K Kleine Schaars,Allan H Young,Ramona Moldovan et al.
K Kleine Schaars et al.
Although the benefits of involvement of persons with lived experience in mental health research have been widely demonstrated, consistent implementation remains challenging. During the 36th ECNP congress in Barcelona, a session was hosted, ...
Olfactory impairment in Huntington's disease: A systematic review and meta-analysis [0.03%]
亨廷顿病嗅觉障碍的系统评价和meta分析
Franco Di Cesare,Cristiana Di Carlo,Leonardo Di Cesare et al.
Franco Di Cesare et al.
Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder characterised by progressive impairment in cognitive, behavioural, and motor functions. Odour identification deficits have long been recognised as a non-motor imp...
Negative symptoms in schizophrenia: Methodological challenges and emerging solutions for outcome measurement [0.03%]
精神分裂症的阴性症状：结局测量的方法挑战和新兴解决方案
Armida Mucci,Michael Davidson,Silvia Zaragoza Domingo et al.
Armida Mucci et al.
Negative symptoms (NS) affect approximately 60% of individuals with schizophrenia and are associated with poor outcomes. They remain an important unmet therapeutic need, not adequately addressed by available antipsychotic drugs, and they ar...
Linking inflammatory and structural neuroimaging biomarkers in treatment-resistant depression: Current evidence and emerging hypotheses [0.03%]
难治性抑郁炎症与结构影像学生物标志物的关联：现有证据和新兴假说
Simge Seren Kirlioglu Balcioglu,Marco Paolini,Bernhard T Baune et al.
Simge Seren Kirlioglu Balcioglu et al.
•TRD is associated with immune alterations across peripheral and central domains.•TRD may show hippocampal and white matter changes that may be linked to immune-related processes.•Integrating immune and neuroimaging findings may contribu...
From health to harm: Cross-sectional analysis of factors associated with orthorexia nervosa [0.03%]
从健康到伤害：正饮食障碍相关因素横断面分析
Annika M Roth,Regina Vollmeyer,Silke Matura
Annika M Roth
The present study systematically examined factors associated with orthorexic tendencies, to provide a clearer understanding of this phenomenon. In a cross-sectional setting, data were collected using an online questionnaire including valida...
Examining varying number of intervention-modules and change in individual networks in young people remitted from depression or anxiety: Exploratory outcomes of the StayFine randomized clinical trial [0.03%]
针对抑郁或焦虑缓解期青年的不同干预模块数量及个体网络变化的考察——来自StayFine随机临床试验的探索性结果
S J Robberegt,C J Albers,B E A M Kooiman et al.
S J Robberegt et al.
In network theory, symptoms of mental disorders constitute networks of interconnected nodes. Interventions can target (aspects of) networks. Assuming that combined intervention-modules target multiple aspects of networks simultaneously, we ...
The effects of omega-3 fatty acids on Wnt activity in iPSC-derived neural stem cells from adult ADHD patients [0.03%]
欧米茄-3脂肪酸对多动症成人患者诱导多功能干细胞来源的神经干细中Wnt活性的影响
Cristine M Yde Ohki,Natalie M Walter,Louisa C Dury et al.
Cristine M Yde Ohki et al.
The canonical Wnt signaling pathway plays a key role in neurodevelopment and in maintaining cellular homeostasis of the central nervous system in adulthood. It regulates essential processes, such as cell proliferation, differentiation, and ...