Tyrosine metabolic reprogramming coordinated with the tricarboxylic acid cycle to drive glioma immune evasion by regulating PD-L1 expression [0.03%]
酪氨酸代谢重编程通过调节PD-L1表达与三羧酸循环协同促进胶质瘤免疫逃逸
Ji-Yan Wang,Xin-Tong Dai,Qing-Le Gao et al.
Ji-Yan Wang et al.
Due to the existence of the blood-brain barrier in glioma, traditional drug therapy has a poor therapeutic outcome. Emerging immunotherapy has been shown to have satisfactory therapeutic effects in solid tumors, and it is clinically instruc...
Jun-Yan Zhang,Z Du Steven,Ke-Hua Liao
Jun-Yan Zhang
Spinal cord injury (SCI) is a nervous system disease characterized by sensory and motor dysfunction, axonal apoptosis, decreased vascular density, and inflammation. At present, surgical treatment, drug treatment, and cell therapy can be use...
Research progress of neonatal hypoxic-ischemic encephalopathy in nonhuman primate models [0.03%]
非人灵长类动物模型新生儿缺氧缺血性脑病的研究进展
Yi-Huan Guan,Hong-Su Zhou,Bo-Yan Luo et al.
Yi-Huan Guan et al.
Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the important complications of neonatal asphyxia, which not only leads to neurological disability but also seriously threatens the life of neonates. Over the years, animal models of H...
The more the neuroticism, the more the susceptibility to Alzheimer's disease. What inspiration can neuroticism provide? [0.03%]
神经质程度越高，患阿尔茨海默病的风险越大。神经质能给我们带来什么启示？
Yifan Yu,Ruitong Yan,Xiaohe Tian
Yifan Yu
Study of neuroticism can provide important insights. Before the inclusion of neuroticism in the study of Alzheimer's disease (AD), clinical and scientific researchers used relatively fixed models to treat AD, such as prescribing fixed doses...
Editorial
Ibrain. 2023 May 12;9(2):231-235. DOI:10.1002/ibra.12102 2023
Thrifty effect of subanesthetic-dose S-ketamine on postoperative opioids and its safety and analgesic effectiveness: A prospective, triple-blind, randomized controlled, polycentric clinical trial [0.03%]
小剂量S-氯胺酮在术后阿片类药物用量、安全性和镇痛效果的节俭效应：一项前瞻性三盲随机对照多中心临床试验
Jun Ding,Yun-Mei Yu,Man Luo et al.
Jun Ding et al.
Aim: To investigate the thrifty effects of subanesthetic-dose S-ketamine on postoperative opioids and its safety and analgesic efficacy. Methods: ...
Yanwen Ding,Chengxi Liu,Yi Zhang
Yanwen Ding
Aging can be defined as a decline of physiological function that is more difficult to reverse, characterized by the loss of the physiological integrity of tissues, organs, and cells of an organism over time. Normal aging is associated with ...
Predictors and occurrence of postoperative cognitive dysfunction in children undergoing noncardiac surgery: A prospective cohort study [0.03%]
小儿非心脏手术后认知功能障碍的发生率和预测因素：前瞻性队列研究
Fang-Fang Han,Xiu-Mei Wang,Hai-Jun Zhang et al.
Fang-Fang Han et al.
In children after cardiac surgery, alterations in cognitive ability and behavior are increasingly common, but whether postoperative cognitive dysfunction (POCD) occurs in children undergoing noncardiac surgery is not known. The present stud...
Research progress in clinical trials of stem cell therapy for stroke and neurodegenerative diseases [0.03%]
干细胞治疗卒中和神经退行性疾病临床研究进展
Shan-Shan Yan,Senio Campos de Souza,Zhen-Dong Xie et al.
Shan-Shan Yan et al.
The incidence of stroke and neurodegenerative diseases is gradually increasing in modern society, but there is still no treatment that is effective enough. Stem cells are cells that can reproduce (self-renew) and differentiate into the body...
Effects of gastrodin on the expression of brain aging-related genes in SAM/P-8 mice based on network pharmacology [0.03%]
基于网络药理学的天麻素对SAM/P-8老年鼠脑衰老相关基因表达的影响研究
Nan Zhao,Rui Jiang,Jun-Jie Cheng et al.
Nan Zhao et al.
Background: Gastrodin can reduce neuronal damage through multiple targets and pathways, and can be useful in preventing and treating degenerative lesions of the central nervous system, but the specific mechanism has not b...
Dyslexia with and without Irlen syndrome: A study of influence on abilities and brain-derived neurotrophic factor level [0.03%]
有和没有Irlen综合征的阅读障碍对其能力及脑源性神经营养因子水平的影响研究
Ehab R Abdelraouf,Ayman Kilany,Mohamed E Elhadidy et al.
Ehab R Abdelraouf et al.
The presence of comorbid Irlen syndrome (IS) in children with developmental dyslexia (DD) may have an impact on their reading and cognitive abilities. Furthermore, the brain-derived neurotrophic factor (BDNF) was reported to be expressed in...