Simple Low-Cost Production of DNA MS2 Virus-Like Particles As Molecular Diagnostic Controls [0.03%]
作为分子诊断对照的DNA MS2类病毒颗粒的简单低成本生产
Michael A Crone,Paul S Freemont
Michael A Crone
Suitable controls are integral for the validation and continued quality assurance of diagnostic workflows. Plasmids, DNA, or in vitro transcribed RNA are often used to validate novel diagnostic workflows, however, they are poorly representa...
Sean Ekins
Sean Ekins
As we have seen throughout history, people and indeed companies can catalyze dramatic changes through invention and innovations. They can create new fields of science that did not exist before. In doing so, new technologies can reshape citi...
David Chimene,Kaivalya A Deo,Jeremy Thomas et al.
David Chimene et al.
For the past decade, additive manufacturing has resulted in significant advances toward fabricating anatomic-size patient-specific scaffolds for tissue models and regenerative medicine. This can be attributed to the development of advanced ...
William A V Beardall,Guy-Bart Stan,Mary J Dunlop
William A V Beardall
Synthetic biology has a natural synergy with deep learning. It can be used to generate large data sets to train models, for example by using DNA synthesis, and deep learning models can be used to inform design, such as by generating novel p...
Public Engagement with Biotechnology Inside and Outside the Classroom: Community-Focused Approaches [0.03%]
课堂内外与生物技术相关的公共参与：以社区为中心的方法论研究
Jorge Jimenez,Joyonna Gamble-George,Giovanna Danies et al.
Jorge Jimenez et al.
Biotechnology offers vast benefits to the environment, animals, and human health, and contributes to improving socioeconomic conditions for the public. However, biotechnology innovations continue to trigger public concern and opposition ove...
Adenine Base Editing In Vivo with a Single Adeno-Associated Virus Vector [0.03%]
单个腺相关病毒载体在体内实现腺嘌呤碱基编辑
Han Zhang,Nathan Bamidele,Pengpeng Liu et al.
Han Zhang et al.
Base editors (BEs) have opened new avenues for the treatment of genetic diseases. However, advances in delivery approaches are needed to enable disease targeting of a broad range of tissues and cell types. Adeno-associated virus (AAV) vecto...
Advancing the Research and Development of Enzyme Replacement Therapies for Lysosomal Storage Diseases [0.03%]
溶酶体贮积症的酶替代疗法研究进展
Ana C Puhl,Sean Ekins
Ana C Puhl
With the increasing interest in developing gene therapies for rare diseases, it is easy to overlook that there are numerous rare lysosomal storage diseases (LSD) with treatments that have been approved by regulatory agencies in the United S...
Label-Free Imaging to Track Reprogramming of Human Somatic Cells [0.03%]
无需标记的重编程过程表观遗传学变化光学成像检测技术及装置
Kaivalya Molugu,Giovanni A Battistini,Tiffany M Heaster et al.
Kaivalya Molugu et al.
The process of reprogramming patient samples to human-induced pluripotent stem cells (iPSCs) is stochastic, asynchronous, and inefficient, leading to a heterogeneous population of cells. In this study, we track the reprogramming status of p...