Feasibility of PROSPECTOR - A Randomized Trial Evaluating Oral Challenge Duration in Penicillin Allergy Evaluation [0.03%]
关于青霉素过敏评估中口服激发持续时间的可行性研究（PROSPECTOR）——一项随机临床试验
Santiago Alvarez-Arango,Kimberly G Blumenthal
Santiago Alvarez-Arango
A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients [0.03%]
住院患者针对性低钠血症矫正的随机试验
Julie Refardt,Laura Potasso,Anissa Pelouto et al.
Julie Refardt et al.
Background: Chronic hyponatremia is associated with adverse outcomes, including falls, neurocognitive disorders, and mortality, but whether hyponatremia itself increases morbidity and mortality, or is simply an indicator ...
Randomized Controlled Trial
NEJM evidence. 2026 Mar;5(3):EVIDoa2500086. DOI:10.1056/EVIDoa2500086 2026
Trifluridine-Tipiracil with and without Bevacizumab in Colorectal Cancer [0.03%]
特氟瑞蒂皮拉西利联合或不联合贝伐单抗治疗结直肠癌
Maliha Nusrat,Ruizhi Zhao,Nadeem Khan et al.
Maliha Nusrat et al.
Background: In the phase 3 SUNLIGHT trial (Study of Trifluridine/Tipiracil With and Without Bevacizumab in Refractory Metastatic Colorectal Cancer Patients), trifluridine-tipiracil+bevacizumab (FTD-TPI+bev) improved the o...
Paenibacillus dendritiformis as a Cause of Destructive Meningitis in Infants [0.03%]
芽胞杆菌属树状分支细菌引起的婴儿破坏性脑膜炎病例报告
Danielle Smith,Rupa Garikipati,Kristen Bastug et al.
Danielle Smith et al.
AbstractInvasive infections due to Paenibacillus species pose a serious risk to young infants and have a high risk of neurologic sequelae. This report describes two infants with severe neurologic manifestations secondary to Paenibacillus de...
Infant Immunity after Maternal Nipocalimab in Severe Hemolytic Disease of the Fetus and Newborn [0.03%]
用于重度胎儿和新生儿溶血病的产妇尼波卡利单抗后的婴儿免疫力
Derek P de Winter,Kenneth J Moise,Leona E Ling et al.
Derek P de Winter et al.
Background: Antenatal treatment with nipocalimab, a neonatal Fc receptor (FcRn) blocker, delayed or prevented fetal anemia, as compared with a historical benchmark, in a phase 2 study of early-onset severe hemolytic disea...
Clinical Trial
NEJM evidence. 2026 Feb;5(2):EVIDoa2500097. DOI:10.1056/EVIDoa2500097 2026
Telemedicine Care on a Mobile Stroke Unit - Time and Tide Wait for No Man [0.03%]
流动中风单元的远程医疗服务——时不我待
Lee H Schwamm
Lee H Schwamm
John E Dobbs,Margaret D Krasne,Rakhi P Naik et al.
John E Dobbs et al.
AbstractMorning Report is a time-honored tradition where physicians-in-training present cases to their colleagues and clinical experts to collaboratively examine an interesting patient presentation. The Morning Report section seeks to carry...
Case Reports
NEJM evidence. 2026 Feb;5(2):EVIDmr2500137. DOI:10.1056/EVIDmr2500137 2026
Ahizechukwu C Eke
Ahizechukwu C Eke
James P Allinson,Jadwiga A Wedzicha
James P Allinson
Solriamfetol for Excessive Sleepiness in Early-Morning Shift Work Disorder [0.03%]
用于早班工作型睡眠障碍所致过度嗜睡的索利那新治疗
Kirsi-Marja Zitting,Katherine R Gilmore,Brandon J Lockyer et al.
Kirsi-Marja Zitting et al.
Background: More individuals work early-morning shifts than night shifts, yet investigations into the treatment of shift work disorder (SWD) in this population are lacking. ...
Randomized Controlled Trial
NEJM evidence. 2026 Feb;5(2):EVIDoa2500190. DOI:10.1056/EVIDoa2500190 2026