Elvin H Geng,Thomas A Odeny,Lina M Montoya et al.
Elvin H Geng et al.
Background: Optimizing retention in human immunodeficiency virus (HIV) treatment may require sequential behavioral interventions based on patients' response. ...
Randomized Controlled Trial
NEJM evidence. 2023 Apr;2(4):10.1056/evidoa2200076. DOI:10.1056/evidoa2200076 2023
Quantifying Treatment Effects in Trials with Multiple Event-Time Outcomes [0.03%]
多重事件时间结果的试验中定量测量处理效应
Brian Lee Claggett,Zachary R McCaw,Lu Tian et al.
Brian Lee Claggett et al.
Background: Data on the occurrence times of multiple outcomes, reflecting the temporal profile of disease burden/progression, have been used to estimate treatment effects in various recent randomized trials. Most procedur...
Endotrophin, a Collagen VI Formation-Derived Peptide, in Heart Failure [0.03%]
心力衰竭中的内营养素，一种由VI型胶原形成衍生的肽
Julio A Chirinos,Lei Zhao,Alexander L Reese-Petersen et al.
Julio A Chirinos et al.
Background: Endotrophin, a collagen type VI-derived peptide, mediates metabolic dysregulation, inflammation, and fibrosis in animal models, but has not been studied in human heart failure (HF). ...
Computerized Games versus Crosswords Training in Mild Cognitive Impairment [0.03%]
计算机游戏与填字游戏训练在轻度认知障碍中的应用比较
D P Devanand,Terry E Goldberg,Min Qian et al.
D P Devanand et al.
Background: Mild cognitive impairment (MCI) increases the risk of dementia. The efficacy of cognitive training in patients with MCI is unclear. Methods: ...
Azithromycin to Prevent Recurrent Wheeze Following Severe Respiratory Syncytial Virus Bronchiolitis [0.03%]
阿奇霉素预防严重呼吸道合胞病毒支气管炎后喘息复发的效果分析
Avraham Beigelman,Mythili Srinivasan,Charles W Goss et al.
Avraham Beigelman et al.
Background: Early-life severe respiratory syncytial virus (RSV) bronchiolitis is a risk factor for childhood asthma. Because azithromycin may attenuate airway inflammation during RSV bronchiolitis, we evaluated whether it...
Colistin Monotherapy versus Combination Therapy for Carbapenem-Resistant Organisms [0.03%]
碳青霉烯耐药菌单用多黏霉素与联合用药疗法的比较研究
Keith S Kaye,Dror Marchaim,Visanu Thamlikitkul et al.
Keith S Kaye et al.
Background: Pneumonia and bloodstream infections (BSI) due to extensively drug-resistant (XDR) Acinetobacter baumannii, XDR Pseudomonas aeruginosa, and carbapenem-resistant Enterobacterales (CRE) are associated with high ...
Lachelle D Weeks,Abhishek Niroula,Donna Neuberg et al.
Lachelle D Weeks et al.
Background: Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS) are defined by somatic mutations in genes associated with myeloid neoplasms (MN) at a variant all...
Long-Term Benefits from Early Antiretroviral Therapy Initiation in HIV Infection [0.03%]
早期启动抗逆转录病毒治疗对艾滋病感染的长期益处
Jens D Lundgren,Abdel G Babiker,Shweta Sharma et al.
Jens D Lundgren et al.
Background: For people with HIV and CD4+ counts >500 cells/mm3, early initiation of antiretroviral therapy (ART) reduces serious AIDS and serious non-AIDS (SNA) risk compared with deferral of treatment until CD4+ counts a...
Covid-19 Rates by Time since Vaccination during Delta Variant Predominance [0.03%]
德尔塔变种盛行期间新冠感染率随接种时间的变化图表
Gabriela Paz-Bailey,Maya Sternberg,Kiersten Kugeler et al.
Gabriela Paz-Bailey et al.
Background: With the emergence of the delta variant, the United States experienced a rapid increase in Covid-19 cases in 2021. We estimated the risk of breakthrough infection and death by month of vaccination as a proxy f...
E-Cigarette Use, Small Airway Fibrosis, and Constrictive Bronchiolitis [0.03%]
电子烟使用与小气道纤维化及支气管收缩症的关系
Lida P Hariri,Bess M Flashner,David J Kanarek et al.
Lida P Hariri et al.
Background: Vaping, including the use of electronic cigarettes (e-cigarettes), has become increasingly prevalent, yet the associated long-term health risks are largely unknown. Given the prevalence of use, particularly am...