Early Surgery or Exercise and Education for Meniscal Tears in Young Adults [0.03%]
年轻成人半月板撕裂的早期手术或运动与教育治疗
Søren T Skou,Per Hölmich,Martin Lind et al.
Søren T Skou et al.
BACKGROUND: Surgery is commonly used to treat meniscal tears; however, to our knowledge, no randomized controlled trials (RCTs) have compared surgery with nonsurgical alternatives in young adults. We hypothesized that early meniscal surgery...
Balanced Crystalloids versus Saline in Critically Ill Adults - A Systematic Review with Meta-Analysis [0.03%]
平衡晶体液与生理盐水在成人重症患者中的应用 - 系统性回顾及元分析
Naomi E Hammond,Fernando G Zampieri,Gian Luca Di Tanna et al.
Naomi E Hammond et al.
BACKGROUND: The comparative efficacy and safety of balanced crystalloid solutions and saline for fluid therapy in critically ill adults remain uncertain. METHODS: We systematically reviewed randomized clinical trials (RCTs) comparing the us...
Phase 2/3 Trial of Molnupiravir for Treatment of Covid-19 in Nonhospitalized Adults [0.03%]
非住院成人新冠患者治疗的莫努匹拉韦二期/三期试验
Yoseph Caraco,Gordon E Crofoot,Pablo Andres Moncada et al.
Yoseph Caraco et al.
BACKGROUND: Safe and effective oral treatments are needed to improve clinical outcomes for nonhospitalized patients with Covid-19. Molnupiravir is an orally administered, small-molecule ribonucleoside prodrug shown to inhibit replication of...
Randomized Trial of Molnupiravir or Placebo in Patients Hospitalized with Covid-19 [0.03%]
随机试验中莫努匹拉韦或安慰剂对COVID-19住院患者的影响
José R Arribas,Sanjay Bhagani,Suzana M Lobo et al.
José R Arribas et al.
BACKGROUND: Molnupiravir is an oral prodrug of β-D-N4-hydroxycytidine, active against SARS-CoV-2 in vitro and in animal models. We report data from the phase 2 component of MOVe-IN, a clinical trial evaluating molnupiravir in patients hosp...
Lise M Helsingen,Mette Kalager
Lise M Helsingen
Colorectal Cancer ScreeningScreening for colorectal cancer is widespread and successful but screening programs across the globe differ in their recommendations. In this article, Helsingen and Kalager review the evidence for different approa...
Chana A Sacks,C Corey Hardin,Sharon-Lise Normand et al.
Chana A Sacks et al.
NEJM Evidence - A New Journal in the NEJM Group Family In January 2022, the NEJM Group will be publishing a new journal, NEJM Evidence. This monthly, peer-reviewed, online-only, general medical journal will publish original research, along ...
Independent Oversight of Clinical Trials through Data and Safety Monitoring Boards [0.03%]
通过数据和安全监控委员会对临床试验进行独立监督
Scott R Evans
Scott R Evans
DSMBs: Protecting Patients and Scientific IntegrityDSMBs look after the welfare of patients enrolled in interventional clinical trials. DSMBs monitor for early establishment of efficacy, findings of harm, futility in obtaining a meaningful ...
Pierre Ankomah,Alyssa Y Castillo,Jessica C O&#x;Neil et al.
Pierre Ankomah et al.
A 66-Year-Old Man with Fever and ConfusionA 66-year-old man with Parkinson's disease and hypertension presented to the ED with fever and confusion after returning to the U.S. from Cambodia. He was febrile with diaphoresis and rigors. What w...
Case Reports
NEJM evidence. 2022 Jan;1(1):EVIDmr2100037. DOI:10.1056/EVIDmr2100037 2022
Acetazolamide to Prevent Adverse Altitude Effects in COPD and Healthy Adults [0.03%]
乙酸唑胺用于预防慢性阻塞性肺病及健康成人出现高原反应不良影响
Michael Furian,Maamed Mademilov,Aline Buergin et al.
Michael Furian et al.
BACKGROUND: We evaluated the efficacy of acetazolamide in preventing adverse altitude effects in patients with moderate to severe chronic obstructive pulmonary disease (COPD) and in healthy lowlanders 40 years of age or older. METHODS: Tria...
Randomized Controlled Trial
NEJM evidence. 2022 Jan;1(1):EVIDoa2100006. DOI:10.1056/EVIDoa2100006 2022
Qin Yao,Máire E Doyle,Qing-Rong Liu et al.
Qin Yao et al.
Background: We sought to determine whether ongoing taste disturbance in the postacute sequelae of coronavirus disease 2019 period is associated with persistent virus in primary taste tissue. ...