Terminal Complement Inhibitor Ravulizumab in Generalized Myasthenia Gravis [0.03%]
泛发性重症肌无力的末端补体抑制剂拉夫利珠单抗
Tuan Vu,Andreas Meisel,Renato Mantegazza et al.
Tuan Vu et al.
BACKGROUND: Generalized myasthenia gravis (gMG) is a rare, chronic, and debilitating autoimmune disease. Activation of the complement system by autoantibodies against the postsynaptic acetylcholine receptor (AChR) leads to destruction of th...
The Case of the Missing Data [0.03%]
失踪的数据案件
Katherine S Takvorian,Chana A Sacks,Charles C Hardin
Katherine S Takvorian
The Case of the Missing DataThis animated video explores how investigators approach missing data in clinical trials.
Potential Identification of Type 2 Diabetes with Elevated Insulin Clearance [0.03%]
通过升高的胰岛素清除率识别2型糖尿病的可能性
Seigo Sugiyama,Hideaki Jinnouchi,Kunio Hieshima et al.
Seigo Sugiyama et al.
BACKGROUND: Decreased blood insulin concentrations resulting from reduced pancreatic β-cell insulin secretion and elevated insulin clearance (IC) could be involved in impaired glucose metabolism in diabetes. Recently, we reported a patient...
Strategies to Account for Design Misspecifications in Randomized Controlled Trials [0.03%]
随机对照试验中考虑设计失误的策略
Amy S Ruppert,Sumithra J Mandrekar
Amy S Ruppert
Mortality rates of infants (younger than 1 year of age) and neonates (younger than 1 month of age) remain unacceptably high in some geographic regions.1,2 After the first week of life, infection is a significant cause of neonatal and postne...
Danielle T Cipres,Anam Khaja,Jessica Shim et al.
Danielle T Cipres et al.
A 13-Year-Old Girl with Primary AmenorrheaA 13-year-old girl presented for evaluation of intermittent lower abdominal pain and absence of menarche. How do you approach the evaluation, and what is the diagnosis?
Eric J Zhao,Deonne Thaddeus V Gauiran,Graham W Slack et al.
Eric J Zhao et al.
A 54-Year-Old Woman with Cutaneous NodulesA 54-year-old woman presented with chronic cutaneous nodules and plaques. How do you approach the evaluation, and what is the diagnosis?
J Sawalla Guseh,Daniel Lieberman,Aaron Baggish
J Sawalla Guseh
Evidence for Exercise in MedicineGuseh, Lieberman, and Baggish launch a new review series on exercise in medicine for NEJM Evidence by describing the epidemic of physical inactivity and examining the evidence for the therapeutic use of exer...
Sarah E Wakeman
Sarah E Wakeman
Opioid Use Disorder Diagnosis and ManagementThe last 20 years have seen a staggering increase in opioid-related morbidity and mortality. Although the consequences of untreated OUDs are significant, OUD is a treatable illness. This article r...
Video-Assisted Thoracoscopic or Open Lobectomy in Early-Stage Lung Cancer [0.03%]
早期肺癌的视频辅助胸腔镜肺叶切除术或开放性肺叶切除术
Eric Lim,Tim J P Batchelor,Joel Dunning et al.
Eric Lim et al.
BACKGROUND: There is limited randomized evidence on the comparative outcomes of early-stage lung cancer resection by video-assisted thoracoscopic surgery (VATS) versus open resection. METHODS: We conducted a parallel-group multicenter rando...