Pitfalls and Prospects - Lessons Learned from Early Palliative Care Research [0.03%]
陷阱与展望 - 早期姑息治疗研究的教训
Joseph A Greer,Jennifer S Temel
Joseph A Greer
Lessons Learned from Early Palliative Care ResearchBuilding on a single-site trial of introducing palliative care soon after cancer diagnosis, researchers set out to conduct a multisite trial. Here, investigators describe how their experien...
Molecular International Prognostic Scoring System for Myelodysplastic Syndromes [0.03%]
骨髓增生异常综合征的分子国际预后评分系统
Elsa Bernard,Heinz Tuechler,Peter L Greenberg et al.
Elsa Bernard et al.
BACKGROUND: Risk stratification and therapeutic decision-making for myelodysplastic syndromes (MDS) are based on the International Prognostic Scoring System–Revised (IPSS-R), which considers hematologic parameters and cytogenetic abnormali...
Fixed-Duration Ibrutinib-Venetoclax in Patients with Chronic Lymphocytic Leukemia and Comorbidities [0.03%]
慢性淋巴细胞白血病合并并发症患者中固定疗程伊布替尼-维奈托克治疗的研究
Arnon P Kater,Carolyn Owen,Carol Moreno et al.
Arnon P Kater et al.
BACKGROUND: GLOW is a phase 3 trial evaluating the efficacy and safety of ibrutinib-venetoclax in older patients and/or those with comorbidities with previously untreated chronic lymphocytic leukemia (CLL). METHODS: We randomly assigned (1:...
Randomized Placebo-Controlled Trial of Reloxaliase in Enteric Hyperoxaluria [0.03%]
治疗肠源性高草酸尿症的雷诺昔拉酶随机安慰剂对照试验
John C Lieske,James E Lingeman,Pietro M Ferraro et al.
John C Lieske et al.
BACKGROUND: Enteric hyperoxaluria is caused by increased intestinal oxalate absorption and can lead to kidney stones, chronic kidney disease, and kidney failure. Reloxaliase is an orally administered recombinant enzyme that degrades oxalate...
Liver-Directed Adeno-Associated Virus-Mediated Gene Therapy for Mucopolysaccharidosis Type VI [0.03%]
肝导向的腺相关病毒介导基因治疗粘多糖贮积症第六型
Nicola Brunetti-Pierri,Rita Ferla,Virginia Maria Ginocchio et al.
Nicola Brunetti-Pierri et al.
BACKGROUND: Mucopolysaccharidosis type VI (MPS VI) is an inherited multisystem lysosomal disorder due to arylsulfatase B (ARSB) deficiency that leads to widespread accumulation of glycosaminoglycans (GAG), which are excreted in increased am...
Participants' Experience in a Clinical Trial of Calcium Supplementation in Pregnancy [0.03%]
孕期钙补充临床试验中参与者经历
José M Belizán
José M Belizán
Calcium Supplementation in Pregnancy Trial This Patient Platform recalls the experience of four pregnant women who were enrolled in a clinical trial in Argentina 35 years ago, as described to narrator and translator, Dr. José M. Belizán. ...
Scott M Gaignard,Alice Q Jiang,Caroline G Coleman et al.
Scott M Gaignard et al.
Back Pain and Lower-Extremity WeaknessA 42-year-old man with HIV presented for evaluation of acute-onset back pain and lower-extremity weakness. How do you approach the evaluation, and what is the diagnosis?
Kevin M Simon,Sharon J Levy,Oscar G Bukstein
Kevin M Simon
Adolescent Substance Use DisordersSubstance use disorders contribute to the leading causes of death among adolescents, including homicide and suicide. Here, Simon et al. review the most recent published data on adolescent substance use diso...
Stephen J Schuster
Stephen J Schuster
ROR1 for Lymphoid Cancers This editorial discusses the first-in-human, phase 1 clinical trial of a novel antibody-drug conjugate, zilovertamab vedotin, in patients with relapsed or refractory mature B-cell malignancies.
Carston Hughley
Carston Hughley
Failure to Screen In this Patient Platform, Carston Hughley relays his experiences with prostate cancer.