Pharmacologic Thromboprophylaxis for Patients Admitted to General Medicine - Is It Necessary? [0.03%]
内科住院患者的药物抗凝预防-是否必要？
Michael Fralick,Michelle Sholzberg
Michael Fralick
Necessity of Pharmacologic ThromboprophylaxisIt is a busy night on call, with 15 new admissions to general internal medicine. The senior resident checks over the admission orders, including low-molecular-weight heparin for venous thromboemb...
Should Combined Hormonal Contraception Be Stopped in the Perioperative Period? [0.03%]
围手术期应停止复方激素避孕药吗？
Katherine Takvorian
Katherine Takvorian
Should Combined Hormonal Contraception Be Stopped in the Perioperative Period?A 34-year-old woman is scheduled to undergo surgery to manage a torn anterior cruciate ligament in her left knee. Her only medication is an estrogen- and progesti...
Case Reports
NEJM evidence. 2022 Jan;1(1):EVIDtt2100050. DOI:10.1056/EVIDtt2100050 2022
Comparative Effectiveness of Allopurinol and Febuxostat in Gout Management [0.03%]
在痛风管理中阿拉普尔醇和Febuxostat的比较效果研究
In the Original Article, "Comparative Effectiveness of Allopurinol and Febuxostat in Gout Management," originally published February 3, 2022 (DOI: 10.1056/EVIDoa2100028), in Table 2, the column "Risk Difference or Risk Ratio (95% CI)†," on...
Published Erratum
NEJM evidence. 2022 Jul;1(7):EVIDx2200150. DOI:10.1056/EVIDx2200150 2022
Ibrutinib Plus Venetoclax for First-Line Chronic Lymphocytic Leukemia Treatment [0.03%]
伊布替尼联合维奈托克一线治疗慢性淋巴细胞白血病
William G Wierda
William G Wierda
Ibrutinib Plus Venetoclax for First-Line Chronic Lymphocytic Leukemia TreatmentSmall-molecule inhibitor targeted therapy for patients with chronic lymphocytic leukemia (CLL) began with ibrutinib, the oral covalent inhibitor of Bruton's tyro...
Fossil-Fuel Pollution and Climate Change - A New NEJM Group Series [0.03%]
化石燃料污染与气候变化 — NEJM 医学前沿新系列文章
Caren G Solomon,Renee N Salas,Debra Malina et al.
Caren G Solomon et al.
Fossil-Fuel Pollution and Climate ChangeThe editors announce a new NEJM Group series on climate change and the increasingly urgent health and care delivery challenges we face. Articles will appear in the New England Journal of Medicine, in ...
Sandrine Lemoine,Justine Bacchetta
Sandrine Lemoine
Hyperoxaluria is defined as urinary oxalate (UOx) excretion greater than 0.5 mmol per day. Hyperoxaluria can result from genetic causes, and these are known as primary hyperoxalurias. Secondary hyperoxaluria results from high intake of oxal...
Early Termination of Clinical Trials for Futility - Considerations for a Data and Safety Monitoring Board [0.03%]
临床试验因无效而提前终止-数据和安全监察委员会需要考虑的事项
Susan S Ellenberg,Pamela A Shaw
Susan S Ellenberg
Early Termination of Clinical Trials for FutilityClinical trials may be stopped for futility if there is little or no chance of demonstrating the hoped-for effect. Reasons include evidence of no treatment effect, substantial missing data th...
Health and Clinical Impacts of Air Pollution and Linkages with Climate Change [0.03%]
空气污染对健康和临床的影响及其与气候变化的关系
Anjeni Keswani,Hana Akselrod,Susan C Anenberg
Anjeni Keswani
Air Pollution Impacts and Climate Change LinksAs part of the NEJM Group series on climate change, Keswani and colleagues review the linkages between climate change and air pollution and suggest strategies that clinicians may use to mitigate...
Katherine S Takvorian,Charles C Hardin,Daniel Muller et al.
Katherine S Takvorian et al.
The Problem of Multiple Comparisons This animated video reviews the problem of multiple comparisons in research studies and explains how performing multiple statistical hypothesis tests can produce associations simply by chance.
Alaina Geary,Nkiruka Arinze,Katie Shean et al.
Alaina Geary et al.
A 41-Year-Old Woman with a Cold FootA 41-year-old woman presented for evaluation of a painful and cold right foot. How do you approach the evaluation, and what is the diagnosis?