Abiraterone and Olaparib for Metastatic Castration-Resistant Prostate Cancer [0.03%]
阿比特龙和奥拉帕利用于转移性去势抵抗性前列腺癌治疗
Noel W Clarke,Andrew J Armstrong,Antoine Thiery-Vuillemin et al.
Noel W Clarke et al.
BACKGROUND: Preclinical studies and results of a phase 2 trial of abiraterone and olaparib suggest a combined antitumor effect when the poly(adenosine diphosphate[ADP]-ribose) polymerase inhibitor olaparib is combined with next-generation h...
What Next? New Drugs, Old Drugs, and New Challenges in Choosing Treatments for Covid-19 [0.03%]
下一步是什么？新冠治疗的新药、旧药和新挑战
Ithan D Peltan,Samuel M Brown
Ithan D Peltan
Much has changed since March 2020, when the World Health Organization declared Covid-19 a pandemic and clinicians around the world began desperately searching for therapies that could help afflicted patients. Barely 2.5 years after SARS-CoV...
Statin Therapy for Prevention of Anthracycline Cardiotoxicity - Another Defeat for Cardioprotection? [0.03%]
用于预防蒽环类抗生素心脏毒性的他汀疗法-又是对心肌保护的另一打击吗？
Sanjay Divakaran,Anju Nohria
Sanjay Divakaran
Reduction in left ventricular (LV) systolic function and clinical heart failure (HF) are well-known potential consequences of anthracycline therapy for cancer. Putative mechanisms include myocardial dysfunction and damage caused by the prod...
Berkeley N Limketkai
Berkeley N Limketkai
Biologic Treatment Withdrawal: Two Sides of a CoinThe advent of monoclonal antibody (biologic) therapies ushered in a wave of highly effective yet relatively safe treatments for inflammatory bowel diseases; their use predicated on assertive...
Tim F Greten,Cecilia Monge
Tim F Greten
Immunotherapy has changed the playing field for multiple cancers, and prime time for unresectable liver cancers may be here now. This issue of NEJM Evidence includes two trials describing novel immunotherapy options for patients with biliar...
Emily Hughes,Katherine S Takvorian,Lori E Dodd et al.
Emily Hughes et al.
Subgroup Analyses: Subpar or Sublime?This animated video explores some of the potential pitfalls of performing subgroup analyses in randomized controlled trials and explains how to approach potential findings with caution.
Gopala K Rangan,Annette T Y Wong,Alexandra Munt et al.
Gopala K Rangan et al.
BACKGROUND: Arginine vasopressin promotes kidney cyst growth in autosomal dominant polycystic kidney disease (ADPKD). Increased water intake reduces arginine vasopressin and urine osmolality and may slow kidney cyst growth. METHODS: In this...
Randomized Controlled Trial
NEJM evidence. 2022 Jan;1(1):EVIDoa2100021. DOI:10.1056/EVIDoa2100021 2022
Big Brother Is Watching: Artificial Intelligence in Endoscopy - Hype or Reality? [0.03%]
老大哥在监视：内镜检查中的人工智能-是炒作还是现实？
Hira I Cheema,Benjamin Tharian
Hira I Cheema
Artificial intelligence (AI) has become a part of many image-based specialties, such as radiology and pathology, as well as medical specialties in which "oscopy" is the key to current practice. In gastroenterology, for example, AI is being ...
Mary Beth Beasley
Mary Beth Beasley
Chronic Airway Disease and Vaping - A First StepThe 2019 outbreak of acute lung disease associated with vaping led to the characterization of electronic cigarette (e-cigarette) or vaping-associated lung injury (EVALI), which primarily corre...
Clinical Trials in the 21st Century - Promising Avenues for Better Studies [0.03%]
二十一世纪的临床试验-更好的研究的新途径
Michael J Pencina,B Taylor Thompson
Michael J Pencina
Innovation in Clinical Trials in the 21st CenturyMedical evidence is rooted in randomized controlled trials but there is a pressing need for innovative designs. Pencina and Thompson introduce a new series that reviews the most promising inn...