How Platform Trials Work [0.03%]
平台试验是怎么运作的
Christos Kotanidis,C Corey Hardin,Daniel Müller et al.
Christos Kotanidis et al.
Clonal Hematopoiesis after Immune Suppression - Adaptive Remodeling without Evolution? Early Lessons from the RACE Trial [0.03%]
免疫抑制后的克隆性血液病：RACE试验的初步结果揭示了适应性重塑而无演化吗？
Simona Pagliuca,Carmelo Gurnari
Simona Pagliuca
Clonal Selection and Evolution after Treatment of Severe Aplastic Anemia [0.03%]
严重再生障碍性贫血治疗后的克隆选择和进化
Fernanda Gutierrez-Rodrigues,Emma M Groarke,Rui Miao et al.
Fernanda Gutierrez-Rodrigues et al.
Background: Clonal hematopoiesis (CH) is a feature of severe aplastic anemia (SAA), but its clinical significance is debated. Methods: ...
Clinical Trial
NEJM evidence. 2026 May;5(5):EVIDoa2500171. DOI:10.1056/EVIDoa2500171 2026
Clonal Dynamics of Hematopoiesis in Aplastic Anemia after Immunosuppression and Eltrombopag [0.03%]
免疫抑制和艾曲波帕治疗后再生障碍性贫血的造血克隆动态变化
Deniz Ece Kaya,Riley Cook,Simona Iacobelli et al.
Deniz Ece Kaya et al.
Background: A Phase 3 randomized trial compared immunosuppressive therapy with or without eltrombopag in untreated patients with aplastic anemia (AA) and showed that addition of eltrombopag increased the rate, rapidity, a...
Clinical Trial
NEJM evidence. 2026 May;5(5):EVIDoa2500174. DOI:10.1056/EVIDoa2500174 2026
Efficacy and Safety of Imsidolimab for Generalized Pustular Psoriasis [0.03%]
伊美司他单抗治疗泛发性脓疱型银屑病的疗效和安全性
Sandra Smieszek,Bartlomiej Przychodzen,Christina Tyner et al.
Sandra Smieszek et al.
Background: Generalized pustular psoriasis (GPP) is a rare, life-threatening disease attributed to aberrant interleukin-36 (IL-36) activity, often due to variants in the IL-36 receptor antagonist gene. Imsidolimab is a no...
Clinical Trial
NEJM evidence. 2026 May;5(5):EVIDoa2500272. DOI:10.1056/EVIDoa2500272 2026
Caroline E Murphy,David W DeGroot,Francis G O&#x;Connor
Caroline E Murphy
AbstractExertional heat illness (EHI) is a leading yet preventable cause of morbidity and mortality in active populations. EHI develops when the body's integrated thermoregulatory responses, including cardiovascular adjustments and evaporat...
Sharon-Lise T Normand
Sharon-Lise T Normand
Selective Decontamination of the Digestive Tract in Adult Mechanically Ventilated Patients - An Updated Systematic Review with Bayesian Meta-Analysis [0.03%]
机械通气成人患者消化道选择性去污染的系统评价和贝叶斯荟萃分析更新
Naomi E Hammond,Anthony Devaux,Ruan Vlok et al.
Naomi E Hammond et al.
Background: There is uncertainty whether the use of selective decontamination of the digestive tract (SDD) as a preventive antimicrobial strategy reduces mortality in adult patients receiving mechanical ventilation in the...
Meta-Analysis
NEJM evidence. 2026 May;5(5):EVIDoa2500264. DOI:10.1056/EVIDoa2500264 2026
John S Angles,Lucila M Zamboni,Jeffery Sauer et al.
John S Angles et al.
AbstractNew York State and New York City health departments have closely monitored the emergence of medetomidine, a sedative that can cause prolonged sedation and a complex withdrawal syndrome, in the illicit drug supply. Drug checking and ...