Demian Christiansen,Sheila Giovanni,Mabel Frias et al.
Demian Christiansen et al.
AbstractA small community outbreak of measles in suburban Cook County, Illinois occurred in September-October 2025. Cook County Department of Public Health investigators identified four measles cases, including one unvaccinated pediatric in...
Linong Ji,Zhifeng Cheng,Jianhua Ma et al.
Linong Ji et al.
Background: HTD1801 is an anti-inflammatory metabolic modulator being developed to treat type 2 diabetes (T2D). The safety and efficacy of HTD1801 as an add-on to metformin among patients with T2D with inadequate glycemic...
John H Stone,Nils Venhoff,Frank Buttgereit et al.
John H Stone et al.
Background: Glucocorticoids (GCs) are standard treatment for giant cell arteritis (GCA). Many patients experience relapses or GC-related toxicity. Secukinumab, a fully human monoclonal antibody that selectively inhibits i...
Outcomes of Pneumonia in ICUs in Low- and Middle-Income Countries - A Systematic Review [0.03%]
低收入及中等收入国家重症监护病房肺炎的预后-系统评价研究
Melissa Pitrowsky,Mariana Balbi Pacheco,Otavio Ranzani et al.
Melissa Pitrowsky et al.
Background: Community-acquired pneumonia (CAP) is a leading cause of intensive care unit (ICU) admission and death in low- and middle-income countries (LMICs). We conducted a systematic review and meta-analysis to estimat...
Meta-Analysis
NEJM evidence. 2026 Jun;5(6):EVIDoa2500244. DOI:10.1056/EVIDoa2500244 2026
Prognostic Score for Myelodysplastic Syndromes Based on Molecular Evolution [0.03%]
基于分子进化的骨髓衰竭性疾病预后评分体系
Ivan Civettini,Federica Malighetti,Matteo Villa et al.
Ivan Civettini et al.
Background: Myelodysplastic syndromes are clonal hematopoietic stem cell disorders characterized by multistep molecular evolution and a variable risk of leukemic transformation. Given this prognostic heterogeneity, accura...
Every Six-Month versus Single-Dose Adjuvant Zoledronate in Early Breast Cancer [0.03%]
早期乳腺癌患者每半年一次或单次辅助唑来膦酸治疗
Mark Clemons,Carol Stober,Gregory R Pond et al.
Mark Clemons et al.
Background: Three-year data from a randomized trial comparing a single zoledronate infusion with infusions every 6 months were previously reported showing that a single infusion was associated with increased patient conve...
Randomized Controlled Trial
NEJM evidence. 2026 Jun;5(6):EVIDoa2500202. DOI:10.1056/EVIDoa2500202 2026
Satoshi Shoji,Pishoy Gouda,Caroline A Falvey et al.
Satoshi Shoji et al.
Background: Prior analyses of trials comparing direct oral anticoagulants (DOACs) to warfarin in atrial fibrillation (AF) have not routinely incorporated patient preferences, despite substantial variation in how patients ...
Guru Subramanian Guru Murthy,Sameem Abedin
Guru Subramanian Guru Murthy
Beyond Equal Weighting - A Step Toward Incorporating Patient Preferences in Atrial Fibrillation Trials [0.03%]
超越等权重分配——在心房颤动试验中纳入患者偏好的一步
Sachin J Shah
Sachin J Shah
Emanuele Savasta,Alessandra Vincenza Fera,Samuele La Mendola et al.
Emanuele Savasta et al.
AbstractMorning Report is a time-honored tradition where physicians-in-training present cases to their colleagues and clinical experts to collaboratively examine an interesting patient presentation. The Morning Report section seeks to carry...
Case Reports
NEJM evidence. 2026 Jun;5(6):EVIDmr2500149. DOI:10.1056/EVIDmr2500149 2026