Evaluating Treatment Effects with Patient-Response-Related Outcomes in Comparative Clinical Trials [0.03%]
基于比较临床试验的患者反应结果评估治疗效果的方法研究
Lu Mao,Lu Tian,Bo Huang et al.
Lu Mao et al.
AbstractIn comparative clinical investigations for nearly all disease types, patient responses - signifying clinically meaningful improvements in health or reductions in disease burden - are routinely employed as key end points for assessin...
Rachel H Joung,Rebecca A Snyder
Rachel H Joung
Marissa S Weiss,Kurt T Barnhart
Marissa S Weiss
Noémie Roland,Epiphane Kolla,Lorraine Poncet et al.
Noémie Roland et al.
Background: Intrauterine devices (IUDs) are effective contraceptives but are also associated with a higher ectopic pregnancy risk than other contraceptive methods. This study assessed ectopic pregnancy risk with varying h...
Helia Ashourizadeh,Nicole Grinspan,Saghar Bagheri et al.
Helia Ashourizadeh et al.
AbstractMorning Report is a time-honored tradition where physicians-in-training present cases to their colleagues and clinical experts to collaboratively examine an interesting patient presentation. The Morning Report section seeks to carry...
Case Reports
NEJM evidence. 2025 Dec;4(12):EVIDmr2500145. DOI:10.1056/EVIDmr2500145 2025
Anthony D Bai,Mark Loeb
Anthony D Bai
AbstractIn the United States, community-acquired pneumonia (CAP) is estimated to be responsible for 1.2 million emergency department visits and 41,210 deaths annually. This review summarizes the epidemiology, pathophysiology, microbiology, ...
Human Challenge Trial of a Nucleoside-Modified Messenger Ribonucleic Acid Influenza Vaccine [0.03%]
一种经核苷修饰的信使核糖核酸流感疫苗的人体挑战试验
Kelly A Lindert,Alex Mann,Anita Geevarughese et al.
Kelly A Lindert et al.
Background: Human challenge trials evaluate protection from influenza exposure following vaccination but have not been reported for nucleoside-modified messenger ribonucleic acid (modRNA) influenza vaccines. ...
Hana M El Sahly,Robert L Atmar
Hana M El Sahly
Digital Nudges to Increase Influenza Vaccination in Patients with Chronic Diseases [0.03%]
数字提示在慢性病患者中增加流感疫苗接种率的效果研究
Niklas Dyrby Johansen,Muthiah Vaduganathan,Ankeet S Bhatt et al.
Niklas Dyrby Johansen et al.
Background: Electronic letters have demonstrated effectiveness in improving vaccination uptake among patients with chronic diseases, but the effects of serial implementation over consecutive influenza seasons are unknown....
Subcutaneous Glycoprotein IIb/IIIa Inhibitor for ST-Elevation Myocardial Infarction - Teaching an Old Drug New Tricks [0.03%]
心肌梗死的皮下糖蛋白IIb/IIIa抑制剂疗法：老药新用
Marc-André d&#x;Entremont,Sanjit S Jolly
Marc-André d&#x;Entremont