Retrotransposon: a versatile player in human preimplantation development and health [0.03%]
端粒酶逆转录转座子在人类植入前发育和健康中的作用
Yuliang Qu,Zsuzsanna Izsvák,Jichang Wang
Yuliang Qu
A comparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats [0.03%]
改善组织衰老的两种NAD+前体化合物的作用效果比较研究——以大鼠为模型对象的研究
Lingling Geng,Bin Zhang,Haisong Liu et al.
Lingling Geng et al.
Metformin (MET) and nicotinamide riboside (NR) have both been reported to exert geroprotective effects in multiple species. However, the mechanism by which MET and NR regulate the aging program and delay aging in multiple tissues remains un...
Yiwen Sun,Wenyang Lin,Ravinder Kaundal et al.
Yiwen Sun et al.
A key objective of the research in the postgenomic era is to decipher the functions of the mammalian genome, which has remained largely enigmatic despite intensive efforts in the functional genomics field over the past two decades. To attac...
Rongbang Tan,Reiner F Haseloff,Yuqian Mo et al.
Rongbang Tan et al.
Vitamin C derivative/AA2P promotes erythroid differentiation by upregulating CA1 [0.03%]
维生素C衍生物/AA2P通过上调CA1促进红细胞分化
Xiaoyu Tan,Meng Li,Yue Liang et al.
Xiaoyu Tan et al.
Vitamin C is used to treat anaemia; however, the mechanism through which vitamin C promotes erythroid differentiation is not comprehensively understood. The in vitro erythroid differentiation induction system can reveal the differentiation ...
Mutations in TUBA4A lead to human zygotic arrest and early developmental failure [0.03%]
TUBA4A基因突变导致人类卵子受精后的早期发育失败
Lin Li,Linfan Mao,Zhiguo Zhang et al.
Lin Li et al.
Deubiquitination of SARM1 by USP13 regulates SARM1 activation and axon degeneration [0.03%]
去泛素化酶USP13通过去除SARM1的K63连接多泛素链来抑制SARM1活化和轴突退行性变
Wenkai Yue,Kai Zhang,Mingsheng Jiang et al.
Wenkai Yue et al.
Sterile alpha and Toll/interleukin 1 receptor motif-containing protein 1 (SARM1) is regarded as a key protein and a central executor of the self-destruction of injured axons. To identify novel molecular players and understand the mechanisms...
Shanshan Wu,Da Wang,Yan Liu
Shanshan Wu
A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement [0.03%]
心脏衰老生物标志物框架：老龄化生物标志物联盟共识声明
Aging Biomarker Consortium;Weiwei Zhang,Yang Che,Xiaoqiang Tang et al.
Aging Biomarker Consortium;Weiwei Zhang et al.
Cardiac aging constitutes a significant risk factor for cardiovascular diseases prevalent among the elderly population. Urgent attention is required to prioritize preventive and management strategies for age-related cardiovascular condition...
Secretagogin regulates asynchronous and spontaneous glutamate release in hippocampal neurons through interaction with Doc2α [0.03%]
-secretagogin通过与Doc2α相互作用调节海马神经元的异步和自发谷氨酸释放
Yingfeng Tu,Jiao Qin,Qiao-Ming Zhang et al.
Yingfeng Tu et al.
Synaptic vesicle (SV) exocytosis is orchestrated by protein machineries consisting of the SNARE complex, Ca2+ sensors, and their partners. Secretagogin (SCGN) is a Ca2+-binding protein involved in multiple forms of vesicle secretion. Althou...