Tcl1 coordinately promotes metabolic shift and regulates totipotency exit [0.03%]
TCPLE1通过协调代谢转换和调控全能性退出促进合子基因组激活
Xin Gao,Chen Gao,Yikai Shi et al.
Xin Gao et al.
During early embryonic development, particularly in the transition from totipotency to pluripotency, energy metabolism is closely linked to cell fate. However, the essential regulators of energy metabolism in this transition remain unclear....
Yunfei Qi,Xinheng He,Xiaoshan Wu et al.
Yunfei Qi et al.
Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development [0.03%]
肠道类器官的应用和进展：肠病建模与治疗手段开发
Xiaoting Xu,Yuping Zhang,Guoxin Huang et al.
Xiaoting Xu et al.
Gut organoids are 3D cellular structures derived from adult or pluripotent stem cells, capable of closely replicating the physiological properties of the gut. These organoids serve as powerful tools for studying gut development and modeling...
A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement [0.03%]
听力系统衰老生物标志物框架：老年生物标志物联盟共识声明
Aging Biomarker Consortium;Xiaolong Fu,Si Wang,Yunhao Wu et al.
Aging Biomarker Consortium;Xiaolong Fu et al.
Hearing is one of the most vital sensory functions in human beings and a crucial means of perceiving and acquiring information from the natural environment. The advancement of human society is closely linked to the development of language, ...
Unraveling the metabolic heterogeneity and commonality in senescent cells using systems modeling [0.03%]
利用系统建模解析衰老细胞中的代谢异质性和共性
Gong-Hua Li,Yu-Hong Li,Qin Yu et al.
Gong-Hua Li et al.
Cellular senescence is a key contributor to aging and aging-related diseases, but its metabolic profiles are not well understood. Here, we performed a systematic analysis of the metabolic features of four types of cellular senescence (repli...
Many are called but few are chosen-from multiple clonal origins to one winner [0.03%]
多重克隆起源归一化为单一Winner式进化路径规律研究
Qihang Chen,Zihan Liu,Bingjie Chen
Qihang Chen
Linoleic acid improves rosacea through repairing mitochondrial damage in keratinocytes [0.03%]
亚油酸通过修复角质细胞线粒体损伤改善玫瑰痤疮
Mei Wang,Wenqin Xiao,Tangxiele Liu et al.
Mei Wang et al.
Rosacea, as a progressive and chronic inflammatory skin disease, lacks safe and effective treatment options. Our previous study reported metabolic disturbance in rosacea patients, containing abnormal lipid metabolism. Building on this, we c...
DDIT3 deficiency ameliorates systemic lupus erythematosus by regulating B cell activation and differentiation [0.03%]
DDIT3的缺失通过调节B细胞的激活和分化缓解系统性红斑狼疮
Xin Dai,Jiali Yu,Yunfei Zhang et al.
Xin Dai et al.
Systemic lupus erythematosus (SLE) is characterized by the overproduction of autoantibodies, and B cells are considered to be the primary cells involved in the development of SLE. Studies have shown that DNA damage responses play a role in ...
Pluripotent stem cell-based immunotherapy: advances in translational research, cell differentiation, and gene modifications [0.03%]
多能干细胞为基础的免疫疗法：在转化研究、细胞分化及基因改造方面的进展
Qi Lei,Hongkui Deng,Shicheng Sun
Qi Lei
Cell-based immunotherapy, recognized as living drugs, is revolutionizing clinical treatment to advanced cancer and shaping the landscape of biomedical research for complex diseases. The differentiation of human pluripotent stem cells (PSCs)...
Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence [0.03%]
通过靶向细胞衰老探索卵巢老化的机制及治疗
Weicheng Tang,Kaichen Wang,Yourong Feng et al.
Weicheng Tang et al.
The ovary is a crucial gonadal organ that supports female reproductive and endocrine functions. Ovarian aging can result in decreased fertility and dysfunction across multiple organs. Research has demonstrated that cellular senescence in va...